Validation of Diagnostic Artificial Intelligence Models for Prostate Pathology in a Middle Eastern Cohort

Peshawa J. Muhammad Ali; Navin Vincent; Saman S. Abdulla; Han N. Mohammed Fadhl; Anders Blilie; Kelvin Szolnoky; Julia Anna Mielcarz; Xiaoyi Ji; Nita Mulliqi; Abdulbasit K. Al-Talabani; Kimmo Kartasalo

arXiv · 2512.17499

Validation of Diagnostic Artificial Intelligence Models for Prostate Pathology in a Middle Eastern Cohort

Peshawa J. Muhammad Ali·Navin Vincent·Saman S. Abdulla·Han N. Mohammed Fadhl·Anders Blilie·Kelvin Szolnoky·Julia Anna Mielcarz·Xiaoyi Ji·Nita Mulliqi·Abdulbasit K. Al-Talabani·Kimmo Kartasalo

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Abstract

Background: Artificial intelligence (AI) is improving the efficiency and accuracy of cancer diagnostics. The performance of pathology AI systems has been almost exclusively evaluated on European and US cohorts from large centers. For global AI adoption in pathology, validation studies on currently under-represented populations - where the potential gains from AI support may also be greatest - are needed. We present the first study with an external validation cohort from the Middle East, focusing on AI-based diagnosis and Gleason grading of prostate cancer. Methods: We collected and digitised 339 prostate biopsy specimens from the Kurdistan region, Iraq, representing a consecutive series of 185 patients spanning the period 2013-2024. We evaluated a task-specific end-to-end AI model and two foundation models in terms of their concordance with pathologists and consistency across samples digitised on three scanner models (Hamamatsu, Leica, and Grundium). Findings: Grading concordance between AI and pathologists was similar to pathologist-pathologist concordance with Cohen's quadratically weighted kappa 0.801 vs. 0.799 (p=0.9824). Cross-scanner concordance was high (quadratically weighted kappa > 0.90) for all AI models and scanner pairs, including low-cost compact scanner. Interpretation: AI models demonstrated pathologist-level performance in prostate histopathology assessment. Compact scanners can provide a route for validation studies in non-digitalised settings and enable cost-effective adoption of AI in laboratories with limited sample volumes. This first openly available digital pathology dataset from the Middle East supports further research into globally equitable AI pathology. Funding: SciLifeLab and Wallenberg Data Driven Life Science Program, Instrumentarium Science Foundation, Karolinska Institutet Research Foundation.

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Peshawa J. Muhammad Ali, Navin Vincent, Saman S. Abdulla, Han N. Mohammed Fadhl, Anders Blilie, Kelvin Szolnoky, Julia Anna Mielcarz, Xiaoyi Ji, Nita Mulliqi, Abdulbasit K. Al-Talabani, Kimmo Kartasalo. 2025-12-19. Validation of Diagnostic Artificial Intelligence Models for Prostate Pathology in a Middle Eastern Cohort. https://arxiv.org/abs/2512.17499

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