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arXiv · 2601.19876

Real-Time Pulsatile Flow Prediction for Realistic, Diverse Intracranial Aneurysm Morphologies using a Graph Transformer and Steady-Flow Data Augmentation

Yiying Sheng·Wenhao Ding·Dylan Roi·Leonard Leong Litt Yeo·Hwa Liang Leo·Choon Hwai Yap
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Abstract

Extensive studies suggested that fluid mechanical markers of intracranial aneurysms (IAs) derived from Computational Fluid Dynamics (CFD) can indicate disease progression risks, but to date this has not been translated clinically. This is because CFD requires specialized expertise and is time-consuming and low throughput, making it difficult to support clinical trials. A deep learning model that maps IA morphology to biomechanical markers can address this, enabling physicians to obtain these markers in real time without performing CFD. Here, we show that a Graph Transformer model that incorporates temporal information, which is supervised by large CFD data, can accurately predict Wall Shear Stress (WSS) across the cardiac cycle from IA surface meshes. The model effectively captures the temporal variations of the WSS pattern, achieving a Structural Similarity Index (SSIM) of up to 0.981 and a maximum-based relative L2 error of 2.8%. Ablation studies and SOTA comparison confirmed its optimality. Further, as pulsatile CFD data is computationally expensive to generate and sample sizes are limited, we engaged a strategy of injecting a large amount of steady-state CFD data, which are extremely low-cost to generate, as augmentation. This approach enhances network performance substantially when pulsatile CFD data sample size is small. Our study provides a proof of concept that temporal sequences cardiovascular fluid mechanical parameters can be computed in real time using a deep learning model from the geometric mesh, and this is achievable even with small pulsatile CFD sample size. Our approach is likely applicable to other cardiovascular scenarios.

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Yiying Sheng, Wenhao Ding, Dylan Roi, Leonard Leong Litt Yeo, Hwa Liang Leo, Choon Hwai Yap. 2026-01-29. Real-Time Pulsatile Flow Prediction for Realistic, Diverse Intracranial Aneurysm Morphologies using a Graph Transformer and Steady-Flow Data Augmentation. https://arxiv.org/abs/2601.19876

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