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arXiv · 2602.00990

Diagnostic Impact of Cine Clips for Thyroid Nodule Assessment on Ultrasound

Jichen Yang·Brian C. Allen·Kirti Magudia·Lisa M. Ho·Chad M. Miller·Maciej A. Mazurowski·Benjamin Wildman-Tobriner
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Abstract

Background: Thyroid ultrasound is commonly performed using a combination of static images and cine clips (video recordings). However, the exact utility and impact of cine images remains unknown. This study aimed to evaluate the impact of cine imaging on accuracy and consistency of thyroid nodule assessment, using the American College of Radiology Thyroid Reporting and Data System (ACR TI-RADS). Methods: 50 benign and 50 malignant thyroid nodules with cytopathology results were included. A reader study with 4 specialty-trained radiologists was then conducted over 3 rounds, assessing only static images in the first two rounds and both static and cine images in the third round. TI-RADS scores and the consequent management recommendations were then evaluated by comparing them to the malignancy status of the nodules. Results: Mean sensitivity for malignancy detection was 0.65 for static images and 0.67 with both static and cine images (p>0.5). Specificity was 0.20 for static images and 0.22 with both static and cine images (p>0.5). Management recommendations were similar with and without cine images. Intrareader agreement on feature assignments remained consistent across all rounds, though TI-RADS point totals were slightly higher with cine images. Conclusion: The inclusion of cine imaging for thyroid nodule assessment on ultrasound did not significantly change diagnostic performance. Current practice guidelines, which do not mandate cine imaging, are sufficient for accurate diagnosis.

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Jichen Yang, Brian C. Allen, Kirti Magudia, Lisa M. Ho, Chad M. Miller, Maciej A. Mazurowski, Benjamin Wildman-Tobriner. 2026-02-01. Diagnostic Impact of Cine Clips for Thyroid Nodule Assessment on Ultrasound. https://arxiv.org/abs/2602.00990

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