Search arXiv⌕ Search
Home/Archive/arXiv

arXiv · 2603.27875

Estimating an initial telomere length distribution from the Laplace transform of its senescence times distribution

Jules Olayé
View original source ↗Read source document ↗Export metadata ↓

Abstract

This work follows from a previous study on the estimation of an initial distribution of telomere length from a senescence times distribution done in [10.1051/m2an/2026022, J. Olay{é}]. In this previous study, we have presented an estimation method based on the fact that our telomere shortening model can be approximated by a transport equation. This method has encouraging results, but fails to provide a good estimation when the variability of the initial telomere length distribution is too small. We improve here this method by approximating our model with an advection-diffusion equation, which allows us to better take into account the randomness of the shortening values. We show that under this approximation, there exists a simple link between the Laplace transform of the initial telomere length distribution and that of the senescence times distribution. Then, by using a numerical method for inverting Laplace transforms called Gaver-Stehfest algorithm, we exploit this link to construct a new estimator.

Explore related subjects

math.AP

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

Jules Olayé. 2026-08-05. Estimating an initial telomere length distribution from the Laplace transform of its senescence times distribution. https://arxiv.org/abs/2603.27875

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related papers

arXiv2026

Blow-Up Dynamics for the $L^2$ critical case of the $2$D Zakharov-Kuznetsov equation

We study blow-up dynamics for the $L^2$-critical cubic Zakharov--Kuznetsov equation in two dimensions, \[ \partial_tu+\partial_{x_1}(Δu+u^3)=0 \qquad\text{on }\mathbb R^2. \] For a class of localized $H^1$ perturbations of the ground state $Q$, we establish a trichotomy near the soliton manifold: exit from a small $L^2$-tube, global asymptotic stability, or finite-time blow-up. In the stable blow-up regime, the solution concentrates a single bubble and \[ λ(t)\sim \ell_0(T-t)^{1/(3-c)}, \] where $\ell_0>0$ depends on the initial datum and $c\in(1,2)$ is an explicit constant determined by the transverse tail of the first-order approximate profile. Consequently, \[ \|\nabla u(t)\|_{L^2} \sim \frac{\|\nabla Q\|_{L^2}} {\ell_0(T-t)^{1/(3-c)}}. \] After subtraction of the concentrating soliton, the radiation converges strongly in $L^p(\mathbb R^2)$ for every $2\leq p<\infty$ to a common nonzero profile $u^*$, while \[ u^*\notin H^s(\mathbb R^2) \qquad\text{for every }s\geq\frac c2. \] The stable blow-up branch is open in the relative $H^1$ topology of the localized class. Finally, every non-soliton datum in this class with non-positive energy blows up in finite time. Interval-arithmetic computer-assisted proofs certify the numerical inputs to the virial coercivity argument. They also yield a rigorous enclosure of $c$, justifying the polynomial moment of order $21$ imposed on the initial data.

math.AP↗
arXiv2026

Propagation of wave packets close to conical intersections

In this paper, we study the propagation of wave packets close to conical intersections with respect to a system of two Schr{ö}dinger equations presenting a codimension 2 crossing. We focus on the dynamics that occur when the wave packets pass through an area close to the crossing, and our main results provide an explicit formula for the outgoing wave packet in terms of the incoming one, with a complete description of its phase and of the classical trajectories it follows, including a drift.

math.AP↗
arXiv2026

A Volterra Calculus for Lie Groupoids

A pseudodifferential Volterra calculus for inverting parabolic differential equations on Lie groupoids is introduced. This enables the study of fundamental solutions of various cases of heat flows on singular manifolds with corners with non-resonant boundary indicial symbols, such as the $b$-manifolds, as well as other geometric bisection covariant heat flows. We also establish the short time asymptotic expansion for the heat kernel of a positive, elliptic differential operator on a Lie groupoid that acts on suitable Sobolev Hilbert modules and is positive definite with respect to the appropriate $L^2$ inner product.

math.AP↗