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arXiv · 2606.00451

ProtStructQA: A Denotation Threshold in Protein Structural Reasoning

Aravind Mandiga·Guoming Li·Jin Lu·Ismailcem Budak Arpinar·Khaled Rasheed·Samuel E. Aggrey
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Abstract

Protein-language systems are often evaluated by whether they generate plausible biological text, but a structural question has a sharper semantics: it denotes a measurement in a 3D coordinate system. We introduce ProtStructQA, an executable benchmark for protein structural question answering in which each natural-language question is generated from a hidden typed domain-specific language (DSL) program and the answer is obtained by executing that program on an AlphaFold-predicted structure. ProtStructQA releases 382.2K questions covering confidence, distances, predicted aligned error (PAE), solvent exposure, secondary structure, topology and contacts, and held-out compositions: a 330K active benchmark over 10K proteins from four species, plus a 52.2K hard-negative robustness pool. Without fine-tuning, we evaluate Qwen3 models from 0.6B to 8B under direct prompting, chain-of-thought, grammar-constrained executable voting, executable voting with chain-of-thought, and multi-turn ReAct-style tool use, and replicate the headline finding on Gemma-3-1B and Gemma-3-12B. We find a capability-dependent denotation threshold between Qwen3-1.7B and Qwen3-4B: below it, tool-mediated ReAct dominates because models often fail to produce executable denotations; above it, chain-of-thought flips from mostly harmful to strongly beneficial and becomes the strongest strategy on most splits. Parse-failure and family-level analyses show that the threshold is a transition from unparseable language to executable structural denotation, while grammar and execution remain selectively valuable for PAE and secondary-structure queries. ProtStructQA reframes scientific QA as compilation from language to measurement and provides a diagnostic testbed for when language models can map words to executable 3D structural measurements.

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Aravind Mandiga, Guoming Li, Jin Lu, Ismailcem Budak Arpinar, Khaled Rasheed, Samuel E. Aggrey. 2026-05-30. ProtStructQA: A Denotation Threshold in Protein Structural Reasoning. https://arxiv.org/abs/2606.00451

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