On Response-Adaptive Targeting Strategies for Multi-Treatment Experiments

Redouane Yagouti; Rémy Degenne; Emilie Kaufmann

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arXiv · 2606.17777

On Response-Adaptive Targeting Strategies for Multi-Treatment Experiments

Redouane Yagouti·Rémy Degenne·Emilie Kaufmann

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Abstract

Response-adaptive randomization (RAR) in clinical trials aims to improve ethical and statistical efficiency by dynamically allocating patients to treatments based on observed outcomes. While RAR based on a target optimal allocation have been extensively studied for two-arms settings, their extension to multi-treatment experiments ($K \geq 2$) remains theoretically fragmented, with most existing methods focusing on specific algorithms or restricted target allocations. In this paper, we introduce a unified framework for response-adaptive targeting, the $α$-Rebalancing Targeting Strategies ($α$RTS), which generalize the ERADE two-armed strategy of Hu et al. [2009]. We prove that all designs in this family share fundamental asymptotic properties: strong consistency, asymptotic normality of allocation proportions and treatment effect estimators, and asymptotic efficiency. To address sparse target regimes (where some treatments are asymptotically eliminated), we further propose $α$RTS with Forced Exploration, a variant that guarantees infinite sampling for all treatments while preserving the asymptotic guarantees. Extensive simulations illustrate the finite-sample behavior of $α$RTS variants in a 3-armed context, highlighting in particular the critical role of forced exploration in sparse settings.

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Redouane Yagouti, Rémy Degenne, Emilie Kaufmann. 2026-06-16. On Response-Adaptive Targeting Strategies for Multi-Treatment Experiments. https://arxiv.org/abs/2606.17777

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