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arXiv · 2606.20914

Experimental Investigation of Surface Passivation Chemistries for Optical Nanotweezers

Maxwell T. Ugwu·Kewei Li·Abayomi Opadele·Theodore Anyika·Justus C. Ndukaife
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Abstract

Nanotweezers are actively investigated as a powerful means to reversibly trap and characterize nanoparticles with profound biological and environmental importance. To ensure that these particles can be reversibly trapped and released, surface passivation is essential. To mitigate the issue of fouling, we investigated the antifouling properties of poly(sodium styrene sulphate) (PSS) synthesized using the Atom Transfer Radical Polymerization (ATRP) technique on our previously reported gold-based Interferometric Electrohydrodynamic Tweezers (IET) device. Fluorescence and interferometric scattering (ISCAT) imaging were used to record trapping performance and study the antifouling properties of our passivated nanotweezer device. The results show that PSS exhibits superior anti-fouling performance against polystyrene nanoparticles when compared to 11-mercaptoundecanoic acid (MUA). By comparing the antifouling properties of PSS and zwitterionic poly(methacryloyloxyethyl phosphorylcholine) (PMPC) in preventing extracellular vesicle adhesion, we found that both exhibited similar performance. Overall, the ATRP technique is broadly applicable across nanotweezer substrates with appropriately chosen initiators.

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Maxwell T. Ugwu, Kewei Li, Abayomi Opadele, Theodore Anyika, Justus C. Ndukaife. 2026-06-18. Experimental Investigation of Surface Passivation Chemistries for Optical Nanotweezers. https://arxiv.org/abs/2606.20914

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