Electric Field Propagation with Spinal Cord Stimulation

Abstract

Spinal cord stimulation is routinely used for the treatment of chronic pain, and is increasingly being investigated for the restoration of movement after paralysis. However, most of our current knowledge on epidural spinal cord stimulation relies on empirical approaches and semi-hybrid models. Hence, optimizing this therapy requires a better theoretical understanding of how stimulation affects the target neural structures. Using the physical properties of tissues combined with an electromagnetic, dielectric, and metallic description of them, we derived the electric field transmission coefficient through a given number of layers of tissue in the spinal cord. We then used this model to calculate the transmission of electric field energy in target neural tissues such as grey or white matter for different pulse width. Simulations suggest that the propagation through the tissues of the spinal cord of an epidurally applied electric field has a complex relationship with the field pulse width. In addition the electric field energy is absorbed at the junction between dura matter and cerebrospinal fluid, and within the cerebrospinal fluid as induced current. These currents hit the different bodies floating within the cerebrospinal fluid, and/or dorsal horn in a very localized region of the spinal cord. The proposed models allow theoretical calculation of the transmission factor for different numbers of layers of tissue within the spinal canal, and for different electric field pulse widths. This eases the prediction of the expected energy reaching each layer of the spinal cord for different tissues, parameters, and electrode configurations, simplifying the optimization of spinal cord stimulation treatment.