Statistical Analysis of Network Collections Using Persistent Homology and Functional Data Analysis

Catherine Higgins; Hulin Wu; Michelle Carey

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arXiv · 2607.23596

Statistical Analysis of Network Collections Using Persistent Homology and Functional Data Analysis

Catherine Higgins·Hulin Wu·Michelle Carey

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Abstract

Statistical analysis of collections of networks, where each network is treated as the primary unit of observation, is of growing importance across a wide range of application domains, including gene regulatory, social, and financial networks. As networks consist of vertices and edges that do not naturally reside in Euclidean space, the direct application of conventional statistical methodologies, such as the computation of means and covariances, principal component analysis, and hypothesis testing, to samples of networks is not straightforward. A central challenge lies in defining meaningful measures of similarity or distance between networks of potentially varying sizes and structural types (e.g., directed, undirected, weighted or unweighted), particularly when no predefined node correspondence exists. To address these challenges, we introduce a framework termed functional topological data analysis (funTDA), which integrates tools from functional data analysis and topological data analysis to facilitate exploratory data analysis and inference on samples of networks. The proposed framework enables the computation of summary statistics, including means and variances, and supports the application of principal component analysis and hypothesis testing to topological features extracted from network data. Through simulation studies involving networks with varying connectivity structures, we demonstrate the ability of funTDA to distinguish between distinct network configurations. The methodology is illustrated through two real-data applications: networks constructed from pairwise word co-occurrences in novels by Jane Austen and Charles Dickens, and gene regulatory networks derived from gene expression measurements for seventeen individuals exposed to H3N2 influenza. In both applications, differences in network topology are assessed using principal component analysis and hypothesis testing.

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Catherine Higgins, Hulin Wu, Michelle Carey. 2026-07-26. Statistical Analysis of Network Collections Using Persistent Homology and Functional Data Analysis. https://arxiv.org/abs/2607.23596

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