Vendor-Agnostic Joint Relaxometry and Myelin Water Fraction Mapping with B1 and Motion Correction

Unay Dorken Gallastegi; Shohei Fujita; Yohan Jun; Antoine Delattre-Klauser; Gian Franco Piredda; Tom Hilbert; Cemre Ariyurek; Eugene Milshteyn; Shizhuo Li; Yuting Chen; Xingwang Yong; Kwok-Shing Chan; Qiang Liu; Seonghwan Yee; Yogesh Rathi; Maxim Zaitsev; Jon-Fredrik Nielsen; Onur Afacan; Camilo Jaimes; Patricia Ellen Grant; Borjan Gagoski; Berkin Bilgic

arXiv · 2608.07687

Vendor-Agnostic Joint Relaxometry and Myelin Water Fraction Mapping with B1 and Motion Correction

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Abstract

Obtaining consistent quantitative maps of myelin content and relaxation times across different sites and vendors is essential for advancing our understanding of brain development. Herein, we present a harmonized, vendor-agnostic magnetic resonance acquisition method designed for joint T1, T2, and myelin water fraction mapping, along with a method for rapid B1+ and B1- field estimation. We used our dictionary-based fitting and multi-compartment modeling for joint mapping of T1, T2 and myelin water fraction. Self-navigation-based retrospective motion correction was integrated with subspace reconstruction to track and correct rigid head motion during scanning, operating without the need for external hardware. Simulations, phantom and in vivo experiments confirmed the sensitivity and accuracy of the method, particularly for short T2 values corresponding to myelin, and demonstrated consistent performance across multiple scanner types. Coupled with the harmonized calibration scan, the proposed package offers a practical tool for multi-site, multi-vendor neuroimaging studies in both adult and pediatric populations.

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Unay Dorken Gallastegi, Shohei Fujita, Yohan Jun, Antoine Delattre-Klauser, Gian Franco Piredda, Tom Hilbert, Cemre Ariyurek, Eugene Milshteyn, Shizhuo Li, Yuting Chen, Xingwang Yong, Kwok-Shing Chan, Qiang Liu, Seonghwan Yee, Yogesh Rathi, Maxim Zaitsev, Jon-Fredrik Nielsen, Onur Afacan, Camilo Jaimes, Patricia Ellen Grant, Borjan Gagoski, Berkin Bilgic. 2026-08-07. Vendor-Agnostic Joint Relaxometry and Myelin Water Fraction Mapping with B1 and Motion Correction. https://arxiv.org/abs/2608.07687

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