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arXiv · 2608.16688

NP-LEAP: Nonparametric Latent Exchangeability Prior for Model-Lean Borrowing from Historical Data

Ethan M. Alt·Miheer Dewaskar·Jacob M. Maronge·Yuelin Lu·Matthew A. Psioda
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Abstract

Bayesian dynamic borrowing (BDB) methods leverage historical data to reduce treatment effect uncertainty, yet existing approaches rely on parametric outcome models susceptible to misspecification. We propose the nonparametric latent exchangeability prior (NP-LEAP), an outcome-agnostic, assumption-lean framework to borrow information from historical data. The NP-LEAP performs individual-level exchangeability assessment, inducing Bayesian model averaging over all possible partitions of the historical data into exchangeable and nonexchangeable subsets. Although applicable to a variety of data types with choice of appropriate kernel, the NP-LEAP is particularly well-suited for studies with time-to-event outcomes, where parametric BDB is potentially triply misspecified - imposing a parametric baseline hazard, the proportional hazards structure, and blanket exchangeability. We establish posterior consistency under mild regularity conditions. Simulation studies demonstrate favorable operating characteristics relative to parametric borrowing methods and nonborrowing semiparametric frequentist methods. We illustrate the method by augmenting the control arm in a randomized trial of patients with non-small cell lung cancer.

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Ethan M. Alt, Miheer Dewaskar, Jacob M. Maronge, Yuelin Lu, Matthew A. Psioda. 2026-08-17. NP-LEAP: Nonparametric Latent Exchangeability Prior for Model-Lean Borrowing from Historical Data. https://arxiv.org/abs/2608.16688

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