A Structural FHMM for Interpretable Disease Trajectories in T2DM

Alessandro Mari; Ekaterina Krymova; Guillaume Obozinski; Maria Luisa Marques de Sa Faquetti; Adrian Martinez de la Torre; Andrea Burden

arXiv · 2608.24328

A Structural FHMM for Interpretable Disease Trajectories in T2DM

Alessandro Mari·Ekaterina Krymova·Guillaume Obozinski·Maria Luisa Marques de Sa Faquetti·Adrian Martinez de la Torre·Andrea Burden

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Abstract

In this work, we propose a structural variant of the Factorial Hidden Markov Model (FHMM) for the analysis of disease trajectories in patients with Type 2 diabetes mellitus (T2DM). The model represents a patient's latent health state as a combination of multiple independent, simultaneously evolving components, associated with comorbidities and lab results. This structured latent representation facilitates the identification of clinically meaningful patient states and clustering of common disease trajectories. We evaluate the proposed approach using The IQVIA Medical Research Data incorporating data from THIN, a Cegedim database of anonymized electronic health records (EHR), identifying patients with a first-ever prescription for a non-insulin antidiabetic drug (NIAD) between January 2006 and December 2019. The model identifies multiple clinically coherent latent components corresponding to known patterns of diabetes-related complications and reveals heterogeneous progression pathways, including distinct microvascular-dominant and multi-organ trajectories associated with elevated comorbidity burden and mortality. These results demonstrate that the proposed framework captures meaningful longitudinal structure in EHR data and provides interpretable insights into the evolution of T2DM and its comorbidities.

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Alessandro Mari, Ekaterina Krymova, Guillaume Obozinski, Maria Luisa Marques de Sa Faquetti, Adrian Martinez de la Torre, Andrea Burden. 2026-08-25. A Structural FHMM for Interpretable Disease Trajectories in T2DM. https://arxiv.org/abs/2608.24328

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