Architectural Robustness to Label Noise Using Variational Quantum Circuits for Medical Image Classification

Abstract

Label noise is prevalent in medical image datasets, arising from observer disagreement and ambiguous cases and deep networks memorize the mislabeled examples at the cost of generalization. Current solutions such as loss correction and sample selection add training complexity and generally assume the noise rate is known or estimable. This paper investigates whether robustness can be obtained architecturally, by routing a frozen backbone's features through a low-dimensional bounded bottleneck and classifying them with a head whose function class is intrinsically smooth. Variational quantum circuits with angle encoding and a linear cost function realise exactly such a class. Their use in medical imaging, however, has been limited by the small number of qubits available on noisy intermediate-scale devices, which typically restricts inputs to low-resolution grayscale images. We therefore couple a frozen ImageNet-pretrained ViT-B/16 backbone to a trainable linear bottleneck and an eight-qubit variational quantum circuit, allowing 224x224 RGB inputs to be processed. Under clean labels the model leads five of six MedMNISTv2 benchmarks against published hybrid quantum-classical models, with margins of 17.4 and 15.7 percentages on BloodMNIST and PathMNIST. The advantage emerges under corrupted labels. At symmetric noise rates of 30% and 50% the model outperforms many published quantum and noise-robust classical baselines on all six datasets without any explicit noise-handling component. Against a control that shares the backbone, bottleneck, parameter count and optimizer and replaces only the circuit with a ReLU layer, it retains 89.75% accuracy on PathMNIST at 50% noise where the control falls to 78.96%. Direct measurement of training dynamics shows that this advantage is not an inability to fit corrupted labels, which the circuit retains, but greater stability under prolonged training on them.