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Life cycle of a minimal protocell - a dissipative particle dynamics (DPD) study

Harold Fellermann·Steen Rasmussen·Hans-Joachim Ziock·Ricard V. Sole
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Abstract

Cross-reactions and other systematic issues generated by the coupling of functional chemical subsystems pose the largest challenge for assembling a viable protocell in the laboratory. Our current work seeks to identify and clarify such key issues as we represent and analyze in simulation a full implementation of a minimal protocell. Using a 3D dissipative particle dynamics (DPD) simulation method we are able to address the coupled diffusion, self-assembly, and chemical reaction processes, required to model a full life cycle of the protocell, the protocell being composed of coupled genetic, metabolic, and container subsystems. Utilizing this minimal structural and functional representation of the constituent molecules, their interactions, and their reactions, we identify and explore the nature of the many linked processes for the full protocellular system.

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Harold Fellermann, Steen Rasmussen, Hans-Joachim Ziock, Ricard V. Sole. 2006-12-12. Life cycle of a minimal protocell - a dissipative particle dynamics (DPD) study. https://arxiv.org/abs/nlin/0612024

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