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On the codon assignment of chain termination signals and the minimization of the effects of frameshift mutations

J. -L. Jestin·A. Kempf
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Abstract

It has been suggested that the minimization of the probability for lethal mutations is a major constraint shaping the genetic code, with the finding that the genetic code is highly protective against transition mutations. Here, we show that recent data on polymerase-induced frameshifts provide a rationale for the codon assignment of chain termination signals (CTS).

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J. -L. Jestin, A. Kempf. 1997-06-12. On the codon assignment of chain termination signals and the minimization of the effects of frameshift mutations. https://arxiv.org/abs/physics/9706019

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