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On The Reconstruction of Interaction Networks with Applications to Transcriptional Regulation

Adam A. Margolin·Ilya Nemenman·Chris Wiggins·Gustavo Stolovitzky·Andrea Califano
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Abstract

A novel information-theoretic method for reconstruction of interaction networks is introduced. We prove that the method is exact for some class of networks. Performance tests on large synthetic transcriptional regulatory networks produce very encouraging results.

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Adam A. Margolin, Ilya Nemenman, Chris Wiggins, Gustavo Stolovitzky, Andrea Califano. 2005-09-18. On The Reconstruction of Interaction Networks with Applications to Transcriptional Regulation. https://arxiv.org/abs/q-bio/0410036

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