arXiv subjects

Alessandro Ingrosso

Publications and source records attributed to Alessandro Ingrosso.

23 records · Page 2Linked to original sources

arXiv2016

Unreasonable Effectiveness of Learning Neural Networks: From Accessible States and Robust Ensembles to Basic Algorithmic Schemes

In artificial neural networks, learning from data is a computationally demanding task in which a large number of connection weights are iteratively tuned through stochastic-gradient-based heuristic processes over a cost-function. It is not well understood how learning occurs in these systems, in particular how they avoid getting trapped in configurations with poor computational performance. Here we study the difficult case of networks with discrete weights, where the optimization landscape is very rough even for simple architectures, and provide theoretical and numerical evidence of the existence of rare - but extremely dense and accessible - regions of configurations in the network weight space. We define a novel measure, which we call the "robust ensemble" (RE), which suppresses trapping by isolated configurations and amplifies the role of these dense regions. We analytically compute the RE in some exactly solvable models, and also provide a general algorithmic scheme which is straightforward to implement: define a cost-function given by a sum of a finite number of replicas of the original cost-function, with a constraint centering the replicas around a driving assignment. To illustrate this, we derive several powerful new algorithms, ranging from Markov Chains to message passing to gradient descent processes, where the algorithms target the robust dense states, resulting in substantial improvements in performance. The weak dependence on the number of precision bits of the weights leads us to conjecture that very similar reasoning applies to more conventional neural networks. Analogous algorithmic schemes can also be applied to other optimization problems.

stat.ML↗

arXiv2016

Discovering Neuronal Cell Types and Their Gene Expression Profiles Using a Spatial Point Process Mixture Model

Cataloging the neuronal cell types that comprise circuitry of individual brain regions is a major goal of modern neuroscience and the BRAIN initiative. Single-cell RNA sequencing can now be used to measure the gene expression profiles of individual neurons and to categorize neurons based on their gene expression profiles. While the single-cell techniques are extremely powerful and hold great promise, they are currently still labor intensive, have a high cost per cell, and, most importantly, do not provide information on spatial distribution of cell types in specific regions of the brain. We propose a complementary approach that uses computational methods to infer the cell types and their gene expression profiles through analysis of brain-wide single-cell resolution in situ hybridization (ISH) imagery contained in the Allen Brain Atlas (ABA). We measure the spatial distribution of neurons labeled in the ISH image for each gene and model it as a spatial point process mixture, whose mixture weights are given by the cell types which express that gene. By fitting a point process mixture model jointly to the ISH images, we infer both the spatial point process distribution for each cell type and their gene expression profile. We validate our predictions of cell type-specific gene expression profiles using single cell RNA sequencing data, recently published for the mouse somatosensory cortex. Jointly with the gene expression profiles, cell features such as cell size, orientation, intensity and local density level are inferred per cell type.

q-bio.NC↗

arXiv2016

Local entropy as a measure for sampling solutions in Constraint Satisfaction Problems

We introduce a novel Entropy-driven Monte Carlo (EdMC) strategy to efficiently sample solutions of random Constraint Satisfaction Problems (CSPs). First, we extend a recent result that, using a large-deviation analysis, shows that the geometry of the space of solutions of the Binary Perceptron Learning Problem (a prototypical CSP), contains regions of very high-density of solutions. Despite being sub-dominant, these regions can be found by optimizing a local entropy measure. Building on these results, we construct a fast solver that relies exclusively on a local entropy estimate, and can be applied to general CSPs. We describe its performance not only for the Perceptron Learning Problem but also for the random $K$-Satisfiabilty Problem (another prototypical CSP with a radically different structure), and show numerically that a simple zero-temperature Metropolis search in the smooth local entropy landscape can reach sub-dominant clusters of optimal solutions in a small number of steps, while standard Simulated Annealing either requires extremely long cooling procedures or just fails. We also discuss how the EdMC can heuristically be made even more efficient for the cases we studied.

cond-mat.dis-nn↗

arXiv2015

Subdominant Dense Clusters Allow for Simple Learning and High Computational Performance in Neural Networks with Discrete Synapses

We show that discrete synaptic weights can be efficiently used for learning in large scale neural systems, and lead to unanticipated computational performance. We focus on the representative case of learning random patterns with binary synapses in single layer networks. The standard statistical analysis shows that this problem is exponentially dominated by isolated solutions that are extremely hard to find algorithmically. Here, we introduce a novel method that allows us to find analytical evidence for the existence of subdominant and extremely dense regions of solutions. Numerical experiments confirm these findings. We also show that the dense regions are surprisingly accessible by simple learning protocols, and that these synaptic configurations are robust to perturbations and generalize better than typical solutions. These outcomes extend to synapses with multiple states and to deeper neural architectures. The large deviation measure also suggests how to design novel algorithmic schemes for optimization based on local entropy maximization.

cond-mat.dis-nn↗

arXiv2014

The zero-patient problem with noisy observations

A Belief Propagation approach has been recently proposed for the zero-patient problem in a SIR epidemics. The zero-patient problem consists in finding the initial source of an epidemic outbreak given observations at a later time. In this work, we study a harder but related inference problem, in which observations are noisy and there is confusion between observed states. In addition to studying the zero-patient problem, we also tackle the problem of completing and correcting the observations possibly finding undiscovered infected individuals and false test results. Moreover, we devise a set of equations, based on the variational expression of the Bethe free energy, to find the zero patient along with maximum-likelihood epidemic parameters. We show, by means of simulated epidemics, how this method is able to infer details on the past history of an epidemic outbreak based solely on the topology of the contact network and a single snapshot of partial and noisy observations.

q-bio.PE↗