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Alexei Korolev

Publications and source records attributed to Alexei Korolev.

2 recordsLinked to original sources

Towards Trustworthy Physical AI: From Theory to Practice Across Life Cycle

Physical AI refers to AI systems that understand, reason about, and act in accordance with the physical world and its underlying laws, dynamics, and constraints. Unlike conventional AI systems, physical AI interacts continuously with uncertain physical environments, and its actions produce consequences that are physically irreversible. As existing trustworthy AI frameworks have been developed primarily for digital AI systems, they do not fully capture the distinctive challenges of physical AI, such as physical safety, cyber-physical security, and physical manufacturing process. To address this gap, we present a survey of trustworthy physical AI principles. First, we characterize the core capabilities and challenges of physical AI. Second, we examine the role of physics in AI. Third, we trace the end-to-end physical AI life cycle across five core stages and introduce Trustworthy Physical AI Operationalization (T-PAIO). Fourth, we develop the Trustworthy Physical AI (T-PAI) framework, a theoretical framework that organizes key trustworthiness principles and provides a foundation for governing trustworthy physical AI systems.

cs.AI

Co-condensation and multivalency enable acetylation-sensitive, concentration-robust assembly of BRD4 condensates

Biomolecular condensates must assemble at specific locations and times inside living cells to perform their biological functions. However, it remains unclear how condensate formation achieves high spatiotemporal precision, responding sensitively to local chemical modifications while remaining robust to fluctuations in protein concentration. Here we study chromatin-associated BRD4 condensates to identify a physical mechanism that enables this combination of sensitivity and robustness. Using an ultra-coarse-grained molecular-dynamics model, we show that co-condensation of BRD4 with chromatin enables rapid assembly below the bulk coexistence concentration, thereby suppressing off-chromatin condensation and enhancing spatial selectivity. Multivalent binding between BRD4 and acetylated histone tails sharpens the dependence of co-condensation on acetylation density through combinatorial effects, increasing contrast between highly acetylated regions and weakly acetylated background chromatin. This mechanism explains how co-condensation and multivalent binding jointly enable sensitive yet robust spatiotemporal targeting by chromatin-associated condensates.

physics.bio-ph