arXiv subjects

Angelos Artemiou

Publications and source records attributed to Angelos Artemiou.

3 recordsLinked to original sources

arXiv2026

The FetalSenseM V2: a wearable and wireless, multi-wavelength NIRS device for continuous monitoring of placental oxygenation and metabolism

We present here the FetalSenseM V2 (FSM V2), a wireless and wearable, multi-wavelength, NIRS device, based on LED illumination at six NIR wavelengths (782, 800, 818, 830, 848 and 888 nm). It utilises two sources located on the flexible wings of the sensor body, and three photodiodes placed symmetrically in its centre at 1 cm from each other. The configuration provides two sets of three source-to-detector distances (SDS) at 3, 4 and 5 cm. FSM V2 allows estimation of dynamic, relative changes in placental concentrations of HbO2, HHb and oxCCO. At the same time, the dual set of SDS also enables the use of multi-distance algorithms, such as spatially-resolved spectroscopy (SRS) and Dual Slope (DS), for estimating placental oxygen saturation (PlO2). FSM V2 is the first example of a new generation of wearable NIRS devices, paving the way for smart and advanced monitoring of placental health at bedside. The FSM V2 was successfully validated on a bench-testing, metrological platform based on optical phantoms, as well as against a gold-standard, time-domain (TD) NIRS system, before moving to preliminary examples of clinical application and usability on pregnancy monitoring trials at University College Lon-don Hospital (UCLH), conducted as part of an in vivo proof-of-concept study.

physics.med-ph↗

arXiv2026

OptoCENTAL: a standardised, bench-testing platform based on phantoms for validating optical systems aimed at clinical monitoring of the placenta

Optical imaging and spectroscopy solutions, such as near-infrared spectroscopy (NIRS) and diffuse optical tomography (DOT), have the potential to provide compact, bedside monitoring of the placenta in the clinic, thanks to recent advancements in miniaturisation and wireless wearability. This would provide neonatologist with continuous assessment of the pregnancy status in real-time, as well as tools to possibly predict delivery outcomes. We present here OptoCENTAL, a standardized platform based on multiple optical phantoms, from digital, through solid to liquid, for a comprehensive bench-testing, characterisation and validation of any photonics solution and instrumentation that aims at in vivo, clinical monitoring of the human placenta. Results: Exemplary applications of the OptoCENTAL platform on different types of optical systems, from wearable, continuous-wave devices to broadband and time-domain NIRS systems, demonstrate the flexibility of its procedures to be implemented with any setup, allowing users to compare performances across different solutions. The results also show the capability of OptoCENTAL to provide quantitative assessment of the major features required by any photonic solution for providing effective and efficient monitoring of the placenta, including basic instrument performances, quantification of monitoring accuracy, as well as depth sensitivity. OptoCENTAL represent the first-of-a-kind effort in standardising bench-testing and validation of optical imaging and spectroscopy methods in the framework of placental clinical applications, further advancing the translation of such modalities into the hospitals, as well as towards future certification and commercialisation of such technologies.

physics.med-ph↗

arXiv2024

A transportable hyperspectral imaging setup based on fast, high-density spectral scanning for in situ quantitative biochemical mapping of fresh tissue biopsies

Histopathological examination of surgical biopsies, such as in glioma and glioblastoma resection, is hindered in current clinical practice by the long times required for the laboratory analysis and pathological screening, typically taking several days or even weeks to be completed. We propose here a transportable, high-density, spectral-scanning based hyperspectral imaging setup, named HyperProbe1, that can provide in situ, fast biochemical analysis and mapping of fresh surgical tissue samples, right after excision, and without the need of fixing or staining. HyperProbe1 is based on spectral scanning via supercontinuum laser illumination filtered with acousto-optic tuneable filters. Such methodology allows the user to select any number and type of wavelength bands in the visible and near-infrared range between 510 and 900 nm (up to 79), and to reconstruct 3D hypercubes composed of high-resolution, widefield images of the surgical samples, where each pixel is associated with a complete spectrum. The system is applied on 11 fresh surgical biopsies of glioma from routine patients, including different grades of tumour classification. Quantitative analysis of the composition of the tissue is performed via fast spectral unmixing to reconstruct mapping of major biomarkers. We also provided a preliminary attempt to infer tumour classification based on differences of composition in the samples, suggesting the possibility to use lipid content and differential cytochrome-c-oxidase concentrations to distinguish between lower and higher grade gliomas. A proof-of-concept of the performances of HyperProbe1 for quantitative, biochemical mapping of surgical biopsies is demonstrated, paving the way for improving current post-surgical, histopathological practice via non-destructive, in situ streamlined screening of fresh tissue samples in a matter of minutes after excision.

physics.med-ph↗