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Anthony Yu

Publications and source records attributed to Anthony Yu.

4 recordsLinked to original sources

Vector incremental treatment effects

Causal questions involving multiple binary treatments are poorly served by standard causal approaches. Potential outcomes grow exponentially with the number of treatments, many treatment combinations are rarely or never observed, and fixing everyone to one combination can require implausible positivity assumptions. We extend incremental propensity score interventions to vector-valued binary treatments, defining causal effects through counterfactual distributions that scale the odds of each treatment by a user-specified factor. Because marginal odds constraints do not uniquely determine the joint distribution, we define it as the minimum-divergence projection of the observed law onto the constrained set, for a user-specified separable divergence, preserving the observed conditional support. The resulting counterfactual mean outcome is identified under consistency and conditional mean exchangeability, without requiring every treatment combination to have positive conditional probability. For a class of smooth divergences, we derive the efficient influence function and construct cross-fitted one-step estimators that are consistent at the parametric rate and asymptotically normal when marginal treatment probabilities are exactly 0, exactly 1, or bounded away from those values. We relax this requirement by specifying a different estimand and deriving a corresponding estimator, which is asymptotically normal under a convergence-rate condition on the estimated active set. We also extend sensitivity analysis to address unmeasured confounding. Applying the framework to 159,466 New York Medicaid beneficiaries with serious mental illness, we estimate how healthcare costs would change under uniform improvements in the odds of six recommended quality-of-care processes. Increasing recommended care is associated with lower total, inpatient, and mental-health cost and higher outpatient cost.

stat.ME↗

Optical Inversion and Spectral Unmixing of Spectroscopic Photoacoustic Images with Physics-Informed Neural Networks

Accurate estimation of the relative concentrations of chromophores in a spectroscopic photoacoustic (sPA) image can reveal immense structural, functional, and molecular information about physiological processes. However, due to nonlinearities and ill-posedness inherent to sPA imaging, concentration estimation is intractable. The Spectroscopic Photoacoustic Optical Inversion Autoencoder (SPOI-AE) aims to address the sPA optical inversion and spectral unmixing problems without assuming linearity. Herein, SPOI-AE was trained and tested on \textit{in vivo} mouse lymph node sPA images with unknown ground truth chromophore concentrations. SPOI-AE better reconstructs input sPA pixels than conventional algorithms while providing biologically coherent estimates for optical parameters, chromophore concentrations, and the percent oxygen saturation of tissue. SPOI-AE's unmixing accuracy was validated using a simulated mouse lymph node phantom ground truth.

cs.LG↗

The Laser Interferometer Space Antenna: Unveiling the Millihertz Gravitational Wave Sky

The first terrestrial gravitational wave interferometers have dramatically underscored the scientific value of observing the Universe through an entirely different window, and of folding this new channel of information with traditional astronomical data for a multimessenger view. The Laser Interferometer Space Antenna (LISA) will broaden the reach of gravitational wave astronomy by conducting the first survey of the millihertz gravitational wave sky, detecting tens of thousands of individual astrophysical sources ranging from white-dwarf binaries in our own galaxy to mergers of massive black holes at redshifts extending beyond the epoch of reionization. These observations will inform - and transform - our understanding of the end state of stellar evolution, massive black hole birth, and the co-evolution of galaxies and black holes through cosmic time. LISA also has the potential to detect gravitational wave emission from elusive astrophysical sources such as intermediate-mass black holes as well as exotic cosmological sources such as inflationary fields and cosmic string cusps.

astro-ph.IM↗

Qubit compatible superconducting interconnects

We present a fabrication process for fully superconducting interconnects compatible with superconducting qubit technology. These interconnects allow for the 3D integration of quantum circuits without introducing lossy amorphous dielectrics. They are composed of indium bumps several microns tall separated from an aluminum base layer by titanium nitride which serves as a diffusion barrier. We measure the whole structure to be superconducting (transition temperature of 1.1$\,$K), limited by the aluminum. These interconnects have an average critical current of 26.8$\,$mA, and mechanical shear and thermal cycle testing indicate that these devices are mechanically robust. Our process provides a method that reliably yields superconducting interconnects suitable for use with superconducting qubits.

quant-ph↗