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arXiv2026

Towards real-time ion range verification via hybrid Compton-PET 3D imaging at isochronous cyclotrons

Range uncertainties remain a major limitation to the full clinical exploitation of proton therapy, motivating reliable in-vivo range-verification techniques. This work presents an experimental investigation of a hybrid Prompt-Gamma Imaging (PGI)--Positron-Emission Tomography (PET) concept at the isochronous cyclotron of the West German Proton Therapy Centre under clinically representative pencil-beam-scanning conditions. Because this accelerator delivers a quasi-continuous beam, a pulsed shoot-and-step structure was imposed to mimic the interruptions associated with clinical energy-layer switching. This enabled PGI during irradiation and PET and delayed Compton imaging during beam-off intervals within the same sequence. Four two-plane Compton cameras were arranged in a co-planar cross-shaped geometry around the beam isocenter. Polyethylene phantoms were irradiated with 100~MeV protons at known positions along the beam axis. Their positions were estimated from reconstructed one-dimensional profiles using supervised machine-learning models trained exclusively on Monte Carlo simulations. PET achieved the best performance, with a root-mean-square deviation of 0.8~mm, followed by PGI with 1.6~mm. Delayed Compton imaging based on e$^{+}$ annihilation photons and $^{10}$C$^{*}$ decays yielded 2.4~mm and 3.8~mm, respectively. PET retained good performance down to 1% of the original event statistics, whereas PGI became increasingly statistics-limited. These results demonstrate the complementary strengths of hybrid PGI--PET and support its development towards millimetre-scale proton-range verification under clinically relevant irradiation conditions.

physics.med-ph↗

arXiv2025

Neutron capture measurements for s-process nucleosynthesis; A review about CERN n_TOF developments and contributions

This article presents a review about the main CERN n\_TOF contributions to the field of neutron-capture experiments of interest for $s$-process nucleosynthesis studies over the last 25 years, with special focus on the measurement of radioactive isotopes. A few recent capture experiments on stable isotopes of astrophysical interest are also discussed. Results on $s$-process branching nuclei are appropriate to illustrate how advances in detection systems and upgrades in the facility have enabled increasingly challenging experiments and, as a consequence, have led to a better understanding and modeling of the $s$-process mechanism of nucleosynthesis. New endeavors combining radioactive-ion beams from ISOLDE for the production of radioisotopically pure samples for activation experiments at the new NEAR facility at n\_TOF are briefly discussed. On the basis of these new exciting results, also current limitations of state-of-the-art TOF and activation techniques will be depicted, thereby showing the pressing need for further upgrades and enhancements on both facilities and detection systems. A brief account of the potential technique based on inverse kinematics for direct neutron-capture measurements is also presented.

nucl-ex↗