arXiv subjects

Cheng Lu

Publications and source records attributed to Cheng Lu.

At least 19 recordsLinked to original sources

arXiv2026

GRACE: Grounded Reasoning via Adapter Composition and Evidence-Aware Calibration for Educational Visual Question Answering

Educational visual question answering, or VQA, requires models to solve curriculum-oriented multiple-choice questions using both language and visual evidence. Compared with conventional open-ended VQA, educational examples often include structured assessment metadata, diagrams or image contexts, and semantically close answer options, creating strong opportunities for question-option shortcuts. We develop and evaluate a parameter-efficient adaptation framework for a frozen multimodal large language model in this setting. We introduce GRACE, Grounded Reasoning via Adapter Composition and Evidence-Aware Calibration, a framework that uses the pedagogical state of each question to specialize lightweight language and vision adaptation. The state combines inference-visible subject, grouped skill, grade, visual-context, question-intent, and option-structure cues. GRACE uses factor-specific prompts and lightweight visual adapters, then applies evidence-aware option calibration to score all candidates under a shared multimodal context. On ScienceQA, GRACE improves a shared-adapter baseline from 90.5 percent to 93.1 percent overall accuracy and from 88.7 percent to 91.2 percent on image-context questions. Removing pedagogical composition, option calibration, or the visual adapter reduces overall accuracy by 1.4, 1.0, and 1.5 points, respectively. These controlled results show that structured educational state is an effective routing signal for parameter-efficient multimodal adaptation.

cs.MM↗

arXiv2026

From Uncertainty to Stability and Fidelity: Guiding Sparse-View 3D Gaussian Splatting with Fisher Information

3D Gaussian Splatting (3DGS) has emerged as a promising technique for novel view synthesis. However, 3DGS requires dense input views to achieve high-quality rendering. In sparse-view scenarios, 3DGS often prones to overfitting, resulting in noticeable artifacts and degraded rendering quality. Previous methods explore to address this issue by introducing additional priors (e.g. depth priors) or integrating regularization techniques (e.g. Dropout). However, these methods are often applied without principled guidance. In particular, prior-based augmentation typically samples novel viewpoints randomly, while Dropout-based regularization randomly removes Gaussians. The compounded randomness introduces uncertainty and instability, limiting the fidelity of novel view synthesis. In this paper, we propose a novel method for sparse-view 3DGS that incorporates Fisher Information to quantitatively guide the utilization of geometric priors and regularization. Specifically, our method comprises two key components: (1) Stereo augmentation with Fisher Information. By leveraging Fisher Information, we actively select most informative supporting views and use depth priors to curate reliable pseudo ground truths, which reduces randomness in augmentation and improves stability and rendering fidelity; (2) Uncertainty-aware regularization. We reduce the instability of Dropout-based regularization by using Fisher Information to quantitatively measure the uncertainty of each 3D Gaussian, and adaptively adjust the removal probability, leading to more stable and effective regularization. With these two components, our method effectively mitigates overfitting and improves the stability of optimization in sparse-view 3DGS, resulting in superior rendering fidelity. Extensive experiments show that our method achieves state-of-the-art performance in sparse-view novel view synthesis benchmarks.

cs.CV↗

arXiv2026

Generative Augmented Inference of LLM-generated Data for Market Research: Theory and Empirical Evidence

Marketing research often relies on parameters estimated from costly human-generated data, such as conjoint survey responses, purchase decisions, and field experiment outcomes. Recent advances in large language models (LLMs) and other AI systems offer inexpensive auxiliary data, but introduce a new challenge: AI outputs are not direct observations of the target outcomes, but could involve high-dimensional representations with complex and unknown relationships to human labels. Conventional methods leverage AI predictions as direct proxies for true labels, which can be inefficient or unreliable when this relationship is weak or misspecified. We propose Generative Augmented Inference (GAI), a general framework that incorporates AI-generated outputs as informative features for estimating models of human-labeled outcomes. GAI uses an orthogonal moment construction that enables consistent estimation and valid inference with a flexible, nonparametric relationship between LLM-generated outputs and human labels. We establish asymptotic normality and a key dominance result: under random labeling, GAI is optimal within a unified class of debiased estimators-including human-data-only estimators and state-of-the-art debiasing methods-and delivers strict improvements under a mild informativeness condition. Even when the labeled sample is not representative of the target population, an extended variant of GAI still dominates the weighted human-data-only estimator. Empirically, GAI outperforms benchmarks across diverse marketing research settings. In a conjoint analysis, it halves estimation error and reduces human labeling requirements by over 75%. In a pricing study, it consistently outperforms alternative estimators when all methods receive identical auxiliary inputs. In a health insurance study, it saves over 90% of labels while preserving decision accuracy.

cs.LG↗

arXiv2026

RayMamba: Ray-Aligned Serialization for Long-Range 3D Object Detection

Long-range 3D object detection remains challenging because LiDAR observations become highly sparse and fragmented in the far field, making reliable context modeling difficult for existing detectors. To address this issue, recent state space model (SSM)-based methods have improved long-range modeling efficiency. However, their effectiveness is still limited by generic serialization strategies that fail to preserve meaningful contextual neighborhoods in sparse scenes. To address this issue, we propose RayMamba, a geometry-aware plug-and-play enhancement for voxel-based 3D detectors. RayMamba organizes sparse voxels into sector-wise ordered sequences through a ray-aligned serialization strategy, which preserves directional continuity and occlusion-related context for subsequent Mamba-based modeling. It is compatible with both LiDAR-only and multimodal detectors, while introducing only modest overhead. Extensive experiments on nuScenes and Argoverse 2 demonstrate consistent improvements across strong baselines. In particular, RayMamba achieves up to 2.49 mAP and 1.59 NDS gain in the challenging 40--50 m range on nuScenes, and further improves VoxelNeXt on Argoverse 2 from 30.3 to 31.2 mAP.

cs.CV↗

arXiv2026

GIP-RAG: An Evidence-Grounded Retrieval-Augmented Framework for Interpretable Gene Interaction and Pathway Impact Analysis

Understanding mechanistic relationships among genes and their impacts on biological pathways is essential for elucidating disease mechanisms and advancing precision medicine. Despite the availability of extensive molecular interaction and pathway data in public databases, integrating heterogeneous knowledge sources and enabling interpretable multi-step reasoning across biological networks remain challenging. We present GIP-RAG (Gene Interaction Prediction through Retrieval-Augmented Generation), a computational framework that combines biomedical knowledge graphs with large language models (LLMs) to infer and interpret gene interactions. The framework constructs a unified gene interaction knowledge graph by integrating curated data from KEGG, WikiPathways, SIGNOR, Pathway Commons, and PubChem. Given user-specified genes, a query-driven module retrieves relevant subgraphs, which are incorporated into structured prompts to guide LLM-based stepwise reasoning. This enables identification of direct and indirect regulatory relationships and generation of mechanistic explanations supported by biological evidence. Beyond pairwise interactions, GIP-RAG includes a pathway-level functional impact module that simulates propagation of gene perturbations through signaling networks and evaluates potential pathway state changes. Evaluation across diverse biological scenarios demonstrates that the framework generates consistent, interpretable, and evidence-supported insights into gene regulatory mechanisms. Overall, GIP-RAG provides a general and interpretable approach for integrating knowledge graphs with retrieval-augmented LLMs to support mechanistic reasoning in complex molecular systems.

q-bio.MN↗

arXiv2026

One-Dimensional Metallic Polymeric Nitrogen

The pressure-induced metallic states of light elements attract significant attention, because of potential applications as high-temperature superconductor and high-energy-density material, especially for hydrogen and nitrogen1-10. Several semiconducting polymeric nitrogen phases with three- or two-dimensional sp3-bonded networks were synthesized6-10, but its metallic form remains unobserved. Here, we report the synthesis of a metallic polymeric nitrogen with one-dimensional feature (1D-PN) at 130-140 GPa and above 3000 K. Synchrotron XRD and Raman spectroscopy, supported by DFT calculations, reveal that it adopts an infinite arm-chair like chain with sp2-hybridized pi-bonds. Simulations predict a superconducting transition at 21.19 K under 113 GPa, higher than that reported in high-pressure experiments for non-metallic elements. At ambient pressure, this phase acquiring an energy density of as high as 8.78 kJ/g is not only kinetically stable but also thermodynamically more stable than cubic gauche nitrogen. This multifunctional property profile positions 1D-PN as a disruptive candidate for both electronic and energetic applications.

cond-mat.mtrl-sci↗

arXiv2026

BRIGHT: A Collaborative Generalist-Specialist Foundation Model for Breast Pathology

Generalist pathology foundation models (PFMs), pretrained on large-scale multi-organ datasets, have demonstrated remarkable predictive capabilities across diverse clinical applications. However, their proficiency on the full spectrum of clinically essential tasks within a specific organ system remains an open question due to the lack of large-scale validation cohorts for a single organ as well as the absence of a tailored training paradigm that can effectively translate broad histomorphological knowledge into the organ-specific expertise required for specialist-level interpretation. In this study, we propose BRIGHT, the first PFM specifically designed for breast pathology, trained on over 51,000 breast whole-slide images derived from a cohort of over 40,000 patients across 19 hospitals. BRIGHT employs a collaborative generalist-specialist framework to capture both universal and organ-specific features. To comprehensively evaluate the performance of PFMs on breast oncology, we curate the largest multi-institutional cohorts to date for downstream task development and evaluation, comprising over 25,000 WSIs across 10 hospitals. The validation cohorts cover the full spectrum of breast pathology across 25 distinct clinical tasks spanning diagnosis, biomarker prediction, treatment response and survival prediction. Extensive experiments demonstrate that BRIGHT outperforms five leading generalist PFMs, achieving state-of-the-art (SOTA) performance in 25 of 25 internal validation tasks and in 4 of 11 external validation tasks with excellent heatmap interpretability. By evaluating on large-scale validation cohorts, this study not only demonstrates BRIGHT's clinical utility in breast oncology but also validates a collaborative generalist-specialist paradigm, providing a scalable template for developing PFMs on a specific organ system, accelerating the translation of foundation models into ...

cs.CV↗

arXiv2026

DrivePTS: A Progressive Learning Framework with Textual and Structural Enhancement for Driving Scene Generation

Synthesis of diverse driving scenes serves as a crucial data augmentation technique for validating the robustness and generalizability of autonomous driving systems. Current methods aggregate high-definition (HD) maps and 3D bounding boxes as geometric conditions in diffusion models for conditional scene generation. However, implicit inter-condition dependency causes generation failures when control conditions change independently. Additionally, these methods suffer from insufficient details in both semantic and structural aspects. Specifically, brief and view-invariant captions restrict semantic contexts, resulting in weak background modeling. Meanwhile, the standard denoising loss with uniform spatial weighting neglects foreground structural details, causing visual distortions and blurriness. To address these challenges, we propose DrivePTS, which incorporates three key innovations. Firstly, our framework adopts a progressive learning strategy to mitigate inter-dependency between geometric conditions, reinforced by an explicit mutual information constraint. Secondly, a Vision-Language Model is utilized to generate multi-view hierarchical descriptions across six semantic aspects, providing fine-grained textual guidance. Thirdly, a frequency-guided structure loss is introduced to strengthen the model's sensitivity to high-frequency elements, improving foreground structural fidelity. Extensive experiments demonstrate that our DrivePTS achieves state-of-the-art fidelity and controllability in generating diverse driving scenes. Notably, DrivePTS successfully generates rare scenes where prior methods fail, highlighting its strong generalization ability.

cs.CV↗

arXiv2026

Hierarchical Multi-Scale Graph Learning with Knowledge-Guided Attention for Whole-Slide Image Survival Analysis

We propose a Hierarchical Multi-scale Knowledge-aware Graph Network (HMKGN) that models multi-scale interactions and spatially hierarchical relationships within whole-slide images (WSIs) for cancer prognostication. Unlike conventional attention-based MIL, which ignores spatial organization, or graph-based MIL, which relies on static handcrafted graphs, HMKGN enforces a hierarchical structure with spatial locality constraints, wherein local cellular-level dynamic graphs aggregate spatially proximate patches within each region of interest (ROI) and a global slide-level dynamic graph integrates ROI-level features into WSI-level representations. Moreover, multi-scale integration at the ROI level combines coarse contextual features from broader views with fine-grained structural representations from local patch-graph aggregation. We evaluate HMKGN on four TCGA cohorts (KIRC, LGG, PAAD, and STAD; N=513, 487, 138, and 370) for survival prediction. It consistently outperforms existing MIL-based models, yielding improved concordance indices (10.85% better) and statistically significant stratification of patient survival risk (log-rank p < 0.05).

eess.IV↗

arXiv2026

New reformulations for 0-1 quadratic programming problem using quadratic nonconvex reformulation techniques and valid inequalities

It is well-known that the quadratic convex reformulation (QCR) technique can speed up some general-purpose solvers such as CPLEX and Gurobi. Recently, the method of quadratic nonconvex reformulation (QNR) was proposed, which provides an alternative way for accelerating a solver via reformulation technique. This paper proposes several new reformulations for 0-1 quadratic programming problems using the QNR technique. Such a technique provides more flexibility in adding nonconvex quadratic constraints into the problem formulation, so that some valid inequalities, such as the triangle inequalities, can be incorporated into the formulation to tighten the lower bound of the problem. We analyze the effects of the proposed reformulations on the lower bounds implemented in the solver, and propose some methods to maximize the McCormick relaxation bounds of the reformulations. Our numerical experiments compare the proposed reformulations with the existing quadratic convex reformulations, showing the effectiveness of the proposed reformulations on 0-1 quadratic programming problems.

math.OC↗

arXiv2026

Variable Aggregation-based Perspective Reformulation for Mixed-Integer Convex Optimization with Symmetry

This paper addresses the challenging issue of symmetry in mixed-integer convex optimization problems, which frequently arise in real-world applications such as the unit commitment problem. Although variable aggregation techniques have been employed to mitigate symmetry, their impact on tightening the corresponding continuous relaxation has not been thoroughly investigated. In this work, we propose a new formulation that integrates the perspective reformulation method into the variable aggregation framework, yielding a tighter continuous relaxation for mixed-integer convex optimization problems with symmetric structures. We prove that, in the presence of symmetry, the convex hull of the feasible region associated with each set of aggregated variables can be exactly characterized. These results demonstrate the effectiveness of the proposed reformulation and establish new theoretical foundations for achieving tightness in variable aggregation-based mixed-integer programming formulations.

math.OC↗

arXiv2026

Drive-JEPA: Video JEPA Meets Multimodal Trajectory Distillation for End-to-End Driving

End-to-end autonomous driving increasingly leverages self-supervised video pretraining to learn transferable planning representations. However, pretraining video world models for scene understanding has so far brought only limited improvements. This limitation is compounded by the inherent ambiguity of driving: each scene typically provides only a single human trajectory, making it difficult to learn multimodal behaviors. In this work, we propose Drive-JEPA, a framework that integrates Video Joint-Embedding Predictive Architecture (V-JEPA) with multimodal trajectory distillation for end-to-end driving. First, we adapt V-JEPA for end-to-end driving, pretraining a ViT encoder on large-scale driving videos to produce predictive representations aligned with trajectory planning. Second, we introduce a proposal-centric planner that distills diverse simulator-generated trajectories alongside human trajectories, with a momentum-aware selection mechanism to promote stable and safe behavior. When evaluated on NAVSIM, the V-JEPA representation combined with a simple transformer-based decoder outperforms prior methods by 3 PDMS in the perception-free setting. The complete Drive-JEPA framework achieves 93.3 PDMS on v1 and 87.8 EPDMS on v2, setting a new state-of-the-art.

cs.CV↗

arXiv2025

An Efficient Solution Method for Solving Convex Separable Quadratic Optimization Problems

Convex separable quadratic optimization problems occur in many practical applications. In this paper, based on an iterative resolution scheme of the KKT system, we develop an efficient method for solving a quadratic programming problem with a convex separable objective function subject to multiple convex separable constraints. We show that the proposed approach leads to a dual coordinate ascent algorithm and provide a convergence proof. Numerical experiments support the superior performance of the proposed method to that of the Gurobi solver, especially for solving large-scale convex separate quadratic programming problems.

math.OC↗

arXiv2025

Arbitrary Instantaneous Bandwidth Microwave Receiver via Scalable Rydberg Vapor Cell Array with Stark Comb

Rydberg atoms have great potential for microwave (MW) measurements due to their high sensitivity, broad carrier bandwidth, and traceability. However, the narrow instantaneous bandwidth of the MW receiver limits its applications. Improving the instantaneous bandwidth of the receiver is an ongoing challenge. Here, we report on the achievement of an arbitrary instantaneous bandwidth MW receiver via a linear array of scalable Rydberg vapor cells with Stark comb, where the Stark comb consists of an MW frequency comb (MFC) and a position-dependent Stark field. In the presence of the Stark field, the resonance MW transition frequency between two Rydberg states is position dependent, so that we can make each MFC line act as a local oscillator (LO) field to resonantly couple one Rydberg cell. Thus, each cell receives part of a broadband MW signal within its instantaneous bandwidth using atomic heterodyne detection, achieving the measurements of the broadband MW signal simultaneously. In our proof-of-principle experiment, we demonstrate the MW receiver with 210~MHz instantaneous bandwidth using an MFC field with 21 lines. Meanwhile, we achieve an overall sensitivity of 326.6~nVcm$^{-1}$Hz$^{-1/2}$. In principle, the method allows for achieving an arbitrary instantaneous bandwidth of the receiver, provided we have enough MFC lines with enough power. Our work paves the way to design and develop a scalable MW receiver for applications in radar, communication, and spectrum monitoring.

quant-ph↗

arXiv2025

Enhancing Quadratic Programming Solvers via Quadratic Nonconvex Reformulation

In this paper, we consider solving nonconvex quadratic programming problems using modern solvers such as Gurobi and SCIP. It is well-known that the classical techniques of quadratic convex reformulation can improve the computational efficiency of global solvers for mixed-integer quadratic optimization problems. In contrast, the use of quadratic nonconvex reformulation (QNR) has not been previously explored. This paper introduces a QNR framework--an unconventional yet highly effective approach for improving the performance of state-of-the-art quadratic programming solvers such as Gurobi and SCIP. Our computational experiments on diverse nonconvex quadratic programming problem instances demonstrate that QNR can substantially accelerate both Gurobi and SCIP. Notably, with QNR, Gurobi achieves state-of-the-art performance on several benchmark and randomly generated instances.

math.OC↗

arXiv2025

Multi-modal Knowledge Decomposition based Online Distillation for Biomarker Prediction in Breast Cancer Histopathology

Immunohistochemical (IHC) biomarker prediction benefits from multi-modal data fusion analysis. However, the simultaneous acquisition of multi-modal data, such as genomic and pathological information, is often challenging due to cost or technical limitations. To address this challenge, we propose an online distillation approach based on Multi-modal Knowledge Decomposition (MKD) to enhance IHC biomarker prediction in haematoxylin and eosin (H\&E) stained histopathology images. This method leverages paired genomic-pathology data during training while enabling inference using either pathology slides alone or both modalities. Two teacher and one student models are developed to extract modality-specific and modality-general features by minimizing the MKD loss. To maintain the internal structural relationships between samples, Similarity-preserving Knowledge Distillation (SKD) is applied. Additionally, Collaborative Learning for Online Distillation (CLOD) facilitates mutual learning between teacher and student models, encouraging diverse and complementary learning dynamics. Experiments on the TCGA-BRCA and in-house QHSU datasets demonstrate that our approach achieves superior performance in IHC biomarker prediction using uni-modal data. Our code is available at https://github.com/qiyuanzz/MICCAI2025_MKD.

cs.CV↗

arXiv2025

NavigScene: Bridging Local Perception and Global Navigation for Beyond-Visual-Range Autonomous Driving

Autonomous driving systems have made significant advances in Q&A, perception, prediction, and planning based on local visual information, yet they struggle to incorporate broader navigational context that human drivers routinely utilize. We address this critical gap between local sensor data and global navigation information by proposing NavigScene, an auxiliary navigation-guided natural language dataset that simulates a human-like driving environment within autonomous driving systems. Moreover, we develop three complementary paradigms to leverage NavigScene: (1) Navigation-guided Reasoning, which enhances vision-language models by incorporating navigation context into the prompting approach; (2) Navigation-guided Preference Optimization, a reinforcement learning method that extends Direct Preference Optimization to improve vision-language model responses by establishing preferences for navigation-relevant summarized information; and (3) Navigation-guided Vision-Language-Action model, which integrates navigation guidance and vision-language models with conventional driving models through feature fusion. Extensive experiments demonstrate that our approaches significantly improve performance across perception, prediction, planning, and question-answering tasks by enabling reasoning capabilities beyond visual range and improving generalization to diverse driving scenarios. This work represents a significant step toward more comprehensive autonomous driving systems capable of navigating complex, unfamiliar environments with greater reliability and safety.

cs.RO↗

arXiv2025

PromptEVC: Controllable Emotional Voice Conversion with Natural Language Prompts

Controllable emotional voice conversion (EVC) aims to manipulate emotional expressions to increase the diversity of synthesized speech. Existing methods typically rely on predefined labels, reference audios, or prespecified factor values, often overlooking individual differences in emotion perception and expression. In this paper, we introduce PromptEVC that utilizes natural language prompts for precise and flexible emotion control. To bridge text descriptions with emotional speech, we propose emotion descriptor and prompt mapper to generate fine-grained emotion embeddings, trained jointly with reference embeddings. To enhance naturalness, we present a prosody modeling and control pipeline that adjusts the rhythm based on linguistic content and emotional cues. Additionally, a speaker encoder is incorporated to preserve identity. Experimental results demonstrate that PromptEVC outperforms state-of-the-art controllable EVC methods in emotion conversion, intensity control, mixed emotion synthesis, and prosody manipulation. Speech samples are available at https://jeremychee4.github.io/PromptEVC/.

eess.AS↗