arXiv subjects

Chunyong Yang

Publications and source records attributed to Chunyong Yang.

3 recordsLinked to original sources

arXiv2026

CNA: An AI-Oriented Comprehensive Normalized Assessment for Healthy Status and Application to Optimize RRT Strategies by Reinforcement Learning

Millions worldwide require Renal Replacement Therapy (RRT) as a treatment essential for survival. However, optimizing RRT strategies via AI is challenging due to heterogeneous patient dynamics, missing data, and the absence of an AI-oriented health assessment criterion. We propose an AI-Oriented Comprehensive Normalized Assessment (CNA) for healthy status and apply it to optimize RRT strategies by using offline reinforcement learning (RL). The key idea of CNA is transforming vital-sign distributions into a standard normal space, enabling a unified, data-driven health-status score defined by deviations from referent intervals, which also provides an AI-oriented criterion to assess strategy quality and supports RL termination. We further design a structured 23-dimensional state representation that integrates 19 indicators with 4 RRT descriptors, and employ matrix decomposition to reconstruct missing vital signs, improving data completeness for learning. These components are incorporated into multiple offline RL algorithms and validated via systematic ablation studies on RRT feature subsets. Compared with physicians' observed treatments, the best learned strategy reduces mortality from 13.2% to 5.0% (reducing 62.24%) and shortens average in-hospital stay from 308.5 to 250.1 hours (reducing 18.93%), demonstrating both methodological innovation and the potential of CNA-guided RL to improve RRT outcomes in nephrology.

cs.LG↗

arXiv2025

TECM*: A Data-Driven Assessment to Reinforcement Learning Methods and Application to Heparin Treatment Strategy for Surgical Sepsis

Objective: Sepsis is a life-threatening condition caused by severe infection leading to acute organ dysfunction. This study proposes a data-driven metric and a continuous reward function to optimize personalized heparin therapy in surgical sepsis patients. Methods: Data from the MIMIC-IV v1.0 and eICU v2.0 databases were used for model development and evaluation. The training cohort consisted of abdominal surgery patients receiving unfractionated heparin (UFH) after postoperative sepsis onset. We introduce a new RL-based framework: converting the discrete SOFA score to a continuous cxSOFA for more nuanced state and reward functions; Second, defining "good" or "bad" strategies based on cxSOFA by a stepwise manner; Third, proposing a Treatment Effect Comparison Matrix (TECM), analogous to a confusion matrix for classification tasks, to evaluate the treatment strategies. We applied different RL algorithms, Q-Learning, DQN, DDQN, BCQ and CQL to optimize the treatment and comprehensively evaluated the framework. Results: Among the AI-derived strategies, the cxSOFA-CQL model achieved the best performance, reducing mortality from 1.83% to 0.74% with the average hospital stay from 11.11 to 9.42 days. TECM demonstrated consistent outcomes across models, highlighting robustness. Conclusion: The proposed RL framework enables interpretable and robust optimization of heparin therapy in surgical sepsis. Continuous cxSOFA scoring and TECM-based evaluation provide nuanced treatment assessment, showing promise for improving clinical outcomes and decision-support reliability.

cs.LG↗

arXiv2022

The MSXF TTS System for ICASSP 2022 ADD Challenge

This paper presents our MSXF TTS system for Task 3.1 of the Audio Deep Synthesis Detection (ADD) Challenge 2022. We use an end to end text to speech system, and add a constraint loss to the system when training stage. The end to end TTS system is VITS, and the pre-training self-supervised model is wav2vec 2.0. And we also explore the influence of the speech speed and volume in spoofing. The faster speech means the less the silence part in audio, the easier to fool the detector. We also find the smaller the volume, the better spoofing ability, though we normalize volume for submission. Our team is identified as C2, and we got the fourth place in the challenge.

cs.SD↗