Dianbo Liu | Search arXiv

arXiv2026

Clinician-Friendly Foundation Models for Ophthalmic Image Diagnostics without Fine-Tuning or Technical Barriers

Artificial intelligence (AI) shows remarkable potential in medical imaging diagnostics, yet most current models require retraining when applied across different clinical settings, limiting their scalability. We developed GlobeReady, a deployment-oriented platform powered by the RetiGlobe foun- dation model and local feature augmentation. RetiGlobe was pretrained in two stages: 1) self-supervised learning using DINOv2 on 38 million synthetic ophthalmic images, and 2) contrastive learning using CLIP on 475,845 real image-text pairs spanning diverse ethnicities, imaging devices, and geographic regions worldwide. We evaluate GlobeReady on 488,448 ophthalmic images, including color fundus photographs (CFPs) and optical coherence tomography scans, from multi-centres in China, Singapore, Vietnam and the UK. Prospective testing included usability assessment with 31 ophthalmologists. Exploratory analyses evaluated domain generalisability, Bayesian uncertainty quantification, out-of-distribution (OOD) detection, and feature-based case retrieval.

cs.CV↗

arXiv2026

Capsule Lens: Locating and Tracking Concept Geometry in Model Representations

Understanding how concepts are encoded in the internal representations of machine learning models is a central problem in mechanistic interpretability, essential both for the science of deep learning and for the trustworthy deployment of increasingly capable models. Existing approaches to interpret model representations mainly map representations onto more interpretable spaces and do not directly characterize how concepts occupy representation space; various hypotheses have been proposed, but often lack of rigorous validation and largely focus on static representations. In this work, we introduce Capsule Lens, a framework that matches the region a concept occupies with a simple, trackable geometric form, a capsule, defined by several interpretable parameters, fitted in closed form to each concept's geometry and validated on held-out samples. We apply Capsule Lens in two major settings: static and dynamic representations. On static representations, we demonstrate how to locate concept geometry across various models, and how the span and norm curves uncover important geometric characteristics. On dynamic representations, we present three case studies tracking representation drifts induced by distinct training settings, CLIP pretraining, RL post-training on visual question answering, and RL post-training on mathematical reasoning. These analyses reveal qualitatively different geometric dynamics, ranging from broad network-wide restructuring in CLIP pretraining to localized and concept-specific changes in RL post-training. Our results include findings aligned with existing literature as well as novel observations. We believe Capsule Lens stands as a promising tool for locating, analyzing, and tracking concept geometry in both static and dynamic representations.

cs.LG↗