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Eunho Yang

Publications and source records attributed to Eunho Yang.

2 recordsLinked to original sources

SpatialBlock: Enhancing Spatial Intelligence in LVLMs via Synthetic Block-Stacking Problem

Large Vision-Language Models (LVLMs) have achieved strong performance on diverse visual tasks, yet their ability to reconstruct and reason about the 3D structure of the scene depicted in 2D images -- referred to as spatial intelligence -- remains limited. Existing approaches attempt to address this gap by using real-scene spatial question answering datasets that require dense geometric annotations. However, constructing such labels is costly, time-consuming, and often noisy due to reliance on external perception modules. In this work, we propose a novel paradigm inspired by human cognitive development: learning foundational spatial skills through structured block-manipulation tasks. We introduce SpatialBlock-15k, a synthetic dataset of 15,000 block-stacking problems covering 3D-to-2D projection, viewpoint transformation, and structural combination. The dataset further incorporates controlled color modulation as visual cues to encourage anchor-based reasoning in visually complex conditions. Experiments demonstrate that LVLMs trained on our dataset through either direct answering or reasoning-based prediction significantly outperform baselines and generalize to real-world spatial tasks, despite the dataset's synthetic and compact nature. Code and data are available at https://github.com/rsoohyun/SpatialBlock.

cs.CV

SurfSpec: Enhancing Off-Target-Agnostic Specificity by Bounding Pocket-Ligand Geometric Mismatch

Lead optimization in structure-based drug design aims to improve target binding while avoiding unintended interactions with off-target pockets. However, existing affinity-driven methods do not explicitly control specificity, whereas current specificity-aware approaches commonly require prior knowledge of off-target structures. We address off-target-agnostic specificity-aware lead optimization by analyzing the geometric mismatch between a ligand and the target pocket. We provide a conservative specificity lower bound for geometrically separated off-targets without requiring access to off-target structures. By metricizing pocket--ligand mismatch, the triangle inequality shows that reducing target--ligand mismatch improves a conservative lower bound on mismatch to a separated off-target class, which can be translated into a specificity lower bound through an empirical geometry--affinity calibration. Motivated by this analysis, we introduce SurfSpec, an off-target-agnostic lead optimization framework that iteratively grows ligands toward under-occupied regions of the target pocket surface. SurfSpec alternates between linker generation toward selected target-surface patches, which provides geometric pseudo-labels, and refinement under a pocket-conditioned ligand prior, which restores these pseudo-labels into valid ligands. On the CrossDocked2020 test set, SurfSpec reduces geometric mismatch and outperforms evaluated off-target-agnostic lead optimization baselines in empirical specificity, while maintaining competitive target-affinity improvement.

q-bio.QM