arXiv subjects

Han Li

Publications and source records attributed to Han Li.

At least 217 records · Page 12Linked to original sources

arXiv2025

From Pixels to Pathology: Restoration Diffusion for Diagnostic-Consistent Virtual IHC

Hematoxylin and eosin (H&E) staining is the clinical standard for assessing tissue morphology, but it lacks molecular-level diagnostic information. In contrast, immunohistochemistry (IHC) provides crucial insights into biomarker expression, such as HER2 status for breast cancer grading, but remains costly and time-consuming, limiting its use in time-sensitive clinical workflows. To address this gap, virtual staining from H&E to IHC has emerged as a promising alternative, yet faces two core challenges: (1) Lack of fair evaluation of synthetic images against misaligned IHC ground truths, and (2) preserving structural integrity and biological variability during translation. To this end, we present an end-to-end framework encompassing both generation and evaluation in this work. We introduce Star-Diff, a structure-aware staining restoration diffusion model that reformulates virtual staining as an image restoration task. By combining residual and noise-based generation pathways, Star-Diff maintains tissue structure while modeling realistic biomarker variability. To evaluate the diagnostic consistency of the generated IHC patches, we propose the Semantic Fidelity Score (SFS), a clinical-grading-task-driven metric that quantifies class-wise semantic degradation based on biomarker classification accuracy. Unlike pixel-level metrics such as SSIM and PSNR, SFS remains robust under spatial misalignment and classifier uncertainty. Experiments on the BCI dataset demonstrate that Star-Diff achieves state-of-the-art (SOTA) performance in both visual fidelity and diagnostic relevance. With rapid inference and strong clinical alignment,it presents a practical solution for applications such as intraoperative virtual IHC synthesis.

eess.IV↗

arXiv2025

SWE-Debate: Competitive Multi-Agent Debate for Software Issue Resolution

Issue resolution has made remarkable progress thanks to the advanced reasoning capabilities of large language models (LLMs). Recently, agent-based frameworks such as SWE-agent have further advanced this progress by enabling autonomous, tool-using agents to tackle complex software engineering tasks. While existing agent-based issue resolution approaches are primarily based on agents' independent explorations, they often get stuck in local solutions and fail to identify issue patterns that span across different parts of the codebase. To address this limitation, we propose SWE-Debate, a competitive multi-agent debate framework that encourages diverse reasoning paths and achieves more consolidated issue localization. SWE-Debate first creates multiple fault propagation traces as localization proposals by traversing a code dependency graph. Then, it organizes a three-round debate among specialized agents, each embodying distinct reasoning perspectives along the fault propagation trace. This structured competition enables agents to collaboratively converge on a consolidated fix plan. Finally, this consolidated fix plan is integrated into an MCTS-based code modification agent for patch generation. Experiments on the SWE-bench benchmark show that SWE-Debate achieves new state-of-the-art results in open-source agent frameworks and outperforms baselines by a large margin.

cs.SE↗

arXiv2025

GREAT: Guiding Query Generation with a Trie for Recommending Related Search about Video at Kuaishou

Currently, short video platforms have become the primary place for individuals to share experiences and obtain information. To better meet users' needs for acquiring information while browsing short videos, some apps have introduced a search entry at the bottom of videos, accompanied with recommended relevant queries. This scenario is known as query recommendation in video-related search, where core task is item-to-query (I2Q) recommendation. As this scenario has only emerged in recent years, there is a notable scarcity of academic research and publicly available datasets in this domain. To address this gap, we systematically examine the challenges associated with this scenario for the first time. Subsequently, we release a large-scale dataset derived from real-world data pertaining to the query recommendation in video-\textit{\textbf{r}}elated \textit{\textbf{s}}earch on the \textit{\textbf{Kuai}}shou app (\textbf{KuaiRS}). Presently, existing methods rely on embeddings to calculate similarity for matching short videos with queries, lacking deep interaction between the semantic content and the query. In this paper, we introduce a novel LLM-based framework named \textbf{GREAT}, which \textit{\textbf{g}}uides que\textit{\textbf{r}}y g\textit{\textbf{e}}ner\textit{\textbf{a}}tion with a \textit{\textbf{t}}rie to address I2Q recommendation in related search. Specifically, we initially gather high-quality queries with high exposure and click-through rate to construct a query-based trie. During training, we enhance the LLM's capability to generate high-quality queries using the query-based trie. In the inference phase, the query-based trie serves as a guide for the token generation. Finally, we further refine the relevance and literal quality between items and queries via a post-processing module. Extensive offline and online experiments demonstrate the effectiveness of our proposed method.

cs.IR↗

arXiv2025

Generalized bilateral multilevel construction for constant dimension codes from parallel mixed dimension construction

Constant dimension codes (CDCs), as special subspace codes, have received extensive attention due to their applications in random network coding. The basic problem of CDCs is to determine the maximal possible size $A_q(n,d,\{k\})$ for given parameters $q, n, d$, and $k$. This paper introduces criteria for choosing appropriate bilateral identifying vectors compatible with the parallel mixed dimension construction (Des. Codes Cryptogr. 93(1):227--241, 2025). We then utilize the generalized bilateral multilevel construction (Des. Codes Cryptogr. 93(1):197--225, 2025) to improve the parallel mixed dimension construction efficiently. Many new CDCs that are better than the previously best-known codes are constructed.

cs.IT↗

arXiv2025

LRM-1B: Towards Large Routing Model

Vehicle routing problems (VRPs) are central to combinatorial optimization with significant practical implications. Recent advancements in neural combinatorial optimization (NCO) have demonstrated promising results by leveraging neural networks to solve VRPs, yet the exploration of model scaling within this domain remains underexplored. Inspired by the success of model scaling in large language models (LLMs), this study introduces a Large Routing Model with 1 billion parameters (LRM-1B), designed to address diverse VRP scenarios. We present a comprehensive evaluation of LRM-1B across multiple problem variants, distributions, and sizes, establishing state-of-the-art results. Our findings reveal that LRM-1B not only adapts to different VRP challenges but also showcases superior performance, outperforming existing models. Additionally, we explore the scaling behavior of neural routing models from 1M to 1B parameters. Our analysis confirms power-law between multiple model factors and performance, offering critical insights into the optimal configurations for foundation neural routing solvers.

cs.LG↗

arXiv2025

Learning Time-Aware Causal Representation for Model Generalization in Evolving Domains

Endowing deep models with the ability to generalize in dynamic scenarios is of vital significance for real-world deployment, given the continuous and complex changes in data distribution. Recently, evolving domain generalization (EDG) has emerged to address distribution shifts over time, aiming to capture evolving patterns for improved model generalization. However, existing EDG methods may suffer from spurious correlations by modeling only the dependence between data and targets across domains, creating a shortcut between task-irrelevant factors and the target, which hinders generalization. To this end, we design a time-aware structural causal model (SCM) that incorporates dynamic causal factors and the causal mechanism drifts, and propose \textbf{S}tatic-D\textbf{YN}amic \textbf{C}ausal Representation Learning (\textbf{SYNC}), an approach that effectively learns time-aware causal representations. Specifically, it integrates specially designed information-theoretic objectives into a sequential VAE framework which captures evolving patterns, and produces the desired representations by preserving intra-class compactness of causal factors both across and within domains. Moreover, we theoretically show that our method can yield the optimal causal predictor for each time domain. Results on both synthetic and real-world datasets exhibit that SYNC can achieve superior temporal generalization performance.

cs.LG↗

arXiv2025

ASR-enhanced Multimodal Representation Learning for Cross-Domain Product Retrieval

E-commerce is increasingly multimedia-enriched, with products exhibited in a broad-domain manner as images, short videos, or live stream promotions. A unified and vectorized cross-domain production representation is essential. Due to large intra-product variance and high inter-product similarity in the broad-domain scenario, a visual-only representation is inadequate. While Automatic Speech Recognition (ASR) text derived from the short or live-stream videos is readily accessible, how to de-noise the excessively noisy text for multimodal representation learning is mostly untouched. We propose ASR-enhanced Multimodal Product Representation Learning (AMPere). In order to extract product-specific information from the raw ASR text, AMPere uses an easy-to-implement LLM-based ASR text summarizer. The LLM-summarized text, together with visual data, is then fed into a multi-branch network to generate compact multimodal embeddings. Extensive experiments on a large-scale tri-domain dataset verify the effectiveness of AMPere in obtaining a unified multimodal product representation that clearly improves cross-domain product retrieval.

cs.MM↗

arXiv2025

NeRF-based CBCT Reconstruction needs Normalization and Initialization

Cone Beam Computed Tomography (CBCT) is widely used in medical imaging. However, the limited number and intensity of X-ray projections make reconstruction an ill-posed problem with severe artifacts. NeRF-based methods have achieved great success in this task. However, they suffer from a local-global training mismatch between their two key components: the hash encoder and the neural network. Specifically, in each training step, only a subset of the hash encoder's parameters is used (local sparse), whereas all parameters in the neural network participate (global dense). Consequently, hash features generated in each step are highly misaligned, as they come from different subsets of the hash encoder. These misalignments from different training steps are then fed into the neural network, causing repeated inconsistent global updates in training, which leads to unstable training, slower convergence, and degraded reconstruction quality. Aiming to alleviate the impact of this local-global optimization mismatch, we introduce a Normalized Hash Encoder, which enhances feature consistency and mitigates the mismatch. Additionally, we propose a Mapping Consistency Initialization(MCI) strategy that initializes the neural network before training by leveraging the global mapping property from a well-trained model. The initialized neural network exhibits improved stability during early training, enabling faster convergence and enhanced reconstruction performance. Our method is simple yet effective, requiring only a few lines of code while substantially improving training efficiency on 128 CT cases collected from 4 different datasets, covering 7 distinct anatomical regions.

eess.IV↗

arXiv2025

DepthSeg: Depth prompting in remote sensing semantic segmentation

Remote sensing semantic segmentation is crucial for extracting detailed land surface information, enabling applications such as environmental monitoring, land use planning, and resource assessment. In recent years, advancements in artificial intelligence have spurred the development of automatic remote sensing semantic segmentation methods. However, the existing semantic segmentation methods focus on distinguishing spectral characteristics of different objects while ignoring the differences in the elevation of the different targets. This results in land cover misclassification in complex scenarios involving shadow occlusion and spectral confusion. In this paper, we introduce a depth prompting two-dimensional (2D) remote sensing semantic segmentation framework (DepthSeg). It automatically models depth/height information from 2D remote sensing images and integrates it into the semantic segmentation framework to mitigate the effects of spectral confusion and shadow occlusion. During the feature extraction phase of DepthSeg, we introduce a lightweight adapter to enable cost-effective fine-tuning of the large-parameter vision transformer encoder pre-trained by natural images. In the depth prompting phase, we propose a depth prompter to model depth/height features explicitly. In the semantic prediction phase, we introduce a semantic classification decoder that couples the depth prompts with high-dimensional land-cover features, enabling accurate extraction of land-cover types. Experiments on the LiuZhou dataset validate the advantages of the DepthSeg framework in land cover mapping tasks. Detailed ablation studies further highlight the significance of the depth prompts in remote sensing semantic segmentation.

cs.CV↗

arXiv2025

Noise Conditional Variational Score Distillation

We propose Noise Conditional Variational Score Distillation (NCVSD), a novel method for distilling pretrained diffusion models into generative denoisers. We achieve this by revealing that the unconditional score function implicitly characterizes the score function of denoising posterior distributions. By integrating this insight into the Variational Score Distillation (VSD) framework, we enable scalable learning of generative denoisers capable of approximating samples from the denoising posterior distribution across a wide range of noise levels. The proposed generative denoisers exhibit desirable properties that allow fast generation while preserve the benefit of iterative refinement: (1) fast one-step generation through sampling from pure Gaussian noise at high noise levels; (2) improved sample quality by scaling the test-time compute with multi-step sampling; and (3) zero-shot probabilistic inference for flexible and controllable sampling. We evaluate NCVSD through extensive experiments, including class-conditional image generation and inverse problem solving. By scaling the test-time compute, our method outperforms teacher diffusion models and is on par with consistency models of larger sizes. Additionally, with significantly fewer NFEs than diffusion-based methods, we achieve record-breaking LPIPS on inverse problems.

cs.CV↗

arXiv2025

OneSug: The Unified End-to-End Generative Framework for E-commerce Query Suggestion

Query suggestion plays a crucial role in enhancing user experience in e-commerce search systems by providing relevant query recommendations that align with users' initial input. This module helps users navigate towards personalized preference needs and reduces typing effort, thereby improving search experience. Traditional query suggestion modules usually adopt multi-stage cascading architectures, for making a well trade-off between system response time and business conversion. But they often suffer from inefficiencies and suboptimal performance due to inconsistent optimization objectives across stages. To address these, we propose OneSug, the first end-to-end generative framework for e-commerce query suggestion. OneSug incorporates a prefix2query representation enhancement module to enrich prefixes using semantically and interactively related queries to bridge content and business characteristics, an encoder-decoder generative model that unifies the query suggestion process, and a reward-weighted ranking strategy with behavior-level weights to capture fine-grained user preferences. Extensive evaluations on large-scale industry datasets demonstrate OneSug's ability for effective and efficient query suggestion. Furthermore, OneSug has been successfully deployed for the entire traffic on the e-commerce search engine in Kuaishou platform for over 1 month, with statistically significant improvements in user top click position (-9.33%), CTR (+2.01%), Order (+2.04%), and Revenue (+1.69%) over the online multi-stage strategy, showing great potential in e-commercial conversion.

cs.IR↗

arXiv2025

Generative Recommender with End-to-End Learnable Item Tokenization

Generative recommendation systems have gained increasing attention as an innovative approach that directly generates item identifiers for recommendation tasks. Despite their potential, a major challenge is the effective construction of item identifiers that align well with recommender systems. Current approaches often treat item tokenization and generative recommendation training as separate processes, which can lead to suboptimal performance. To overcome this issue, we introduce ETEGRec, a novel End-To-End Generative Recommender that unifies item tokenization and generative recommendation into a cohesive framework. Built on a dual encoder-decoder architecture, ETEGRec consists of an item tokenizer and a generative recommender. To enable synergistic interaction between these components, we propose a recommendation-oriented alignment strategy, which includes two key optimization objectives: sequence-item alignment and preference-semantic alignment. These objectives tightly couple the learning processes of the item tokenizer and the generative recommender, fostering mutual enhancement. Additionally, we develop an alternating optimization technique to ensure stable and efficient end-to-end training of the entire framework. Extensive experiments demonstrate the superior performance of our approach compared to traditional sequential recommendation models and existing generative recommendation baselines. Our code is available at https://github.com/RUCAIBox/ETEGRec.

cs.IR↗

arXiv2025

Personalized Query Auto-Completion for Long and Short-Term Interests with Adaptive Detoxification Generation

Query auto-completion (QAC) plays a crucial role in modern search systems. However, in real-world applications, there are two pressing challenges that still need to be addressed. First, there is a need for hierarchical personalized representations for users. Previous approaches have typically used users' search behavior as a single, overall representation, which proves inadequate in more nuanced generative scenarios. Additionally, query prefixes are typically short and may contain typos or sensitive information, increasing the likelihood of generating toxic content compared to traditional text generation tasks. Such toxic content can degrade user experience and lead to public relations issues. Therefore, the second critical challenge is detoxifying QAC systems. To address these two limitations, we propose a novel model (LaD) that captures personalized information from both long-term and short-term interests, incorporating adaptive detoxification. In LaD, personalized information is captured hierarchically at both coarse-grained and fine-grained levels. This approach preserves as much personalized information as possible while enabling online generation within time constraints. To move a futher step, we propose an online training method based on Reject Preference Optimization (RPO). By incorporating a special token [Reject] during both the training and inference processes, the model achieves adaptive detoxification. Consequently, the generated text presented to users is both non-toxic and relevant to the given prefix. We conduct comprehensive experiments on industrial-scale datasets and perform online A/B tests, delivering the largest single-experiment metric improvement in nearly two years of our product. Our model has been deployed on Kuaishou search, driving the primary traffic for hundreds of millions of active users. The code is available at https://github.com/JXZe/LaD.

cs.CL↗

arXiv2025

Learning optimal treatment strategies for intraoperative hypotension using deep reinforcement learning

Traditional methods of surgical decision making heavily rely on human experience and prompt actions, which are variable. A data-driven system generating treatment recommendations based on patient states can be a substantial asset in perioperative decision-making, as in cases of intraoperative hypotension, for which suboptimal management is associated with acute kidney injury (AKI), a common and morbid postoperative complication. We developed a Reinforcement Learning (RL) model to recommend optimum dose of intravenous (IV) fluid and vasopressors during surgery to avoid intraoperative hypotension and postoperative AKI. We retrospectively analyzed 50,021 surgeries from 42,547 adult patients who underwent major surgery at a quaternary care hospital between June 2014 and September 2020. Of these, 34,186 surgeries were used for model training and 15,835 surgeries were reserved for testing. We developed a Deep Q-Networks based RL model using 16 variables including intraoperative physiologic time series, total dose of IV fluid and vasopressors extracted for every 15-minute epoch. The model replicated 69% of physician's decisions for the dosage of vasopressors and proposed higher or lower dosage of vasopressors than received in 10% and 21% of the treatments, respectively. In terms of IV fluids, the model's recommendations were within 0.05 ml/kg/15 min of the actual dose in 41% of the cases, with higher or lower doses recommended for 27% and 32% of the treatments, respectively. The model resulted in a higher estimated policy value compared to the physicians' actual treatments, as well as random and zero-drug policies. AKI prevalence was the lowest in patients receiving medication dosages that aligned with model's decisions. Our findings suggest that implementation of the model's policy has the potential to reduce postoperative AKI and improve other outcomes driven by intraoperative hypotension.

q-bio.QM↗

arXiv2025

MoMBS: Mixed-order minibatch sampling enhances model training from diverse-quality images

Natural images exhibit label diversity (clean vs. noisy) in noisy-labeled image classification and prevalence diversity (abundant vs. sparse) in long-tailed image classification. Similarly, medical images in universal lesion detection (ULD) exhibit substantial variations in image quality, encompassing attributes such as clarity and label correctness. How to effectively leverage training images with diverse qualities becomes a problem in learning deep models. Conventional training mechanisms, such as self-paced curriculum learning (SCL) and online hard example mining (OHEM), relieve this problem by reweighting images with high loss values. Despite their success, these methods still confront two challenges: (i) the loss-based measure of sample hardness is imprecise, preventing optimum handling of different cases, and (ii) there exists under-utilization in SCL or over-utilization OHEM with the identified hard samples. To address these issues, this paper revisits the minibatch sampling (MBS), a technique widely used in deep network training but largely unexplored concerning the handling of diverse-quality training samples. We discover that the samples within a minibatch influence each other during training; thus, we propose a novel Mixed-order Minibatch Sampling (MoMBS) method to optimize the use of training samples with diverse qualities. MoMBS introduces a measure that takes both loss and uncertainty into account to surpass a sole reliance on loss and allows for a more refined categorization of high-loss samples by distinguishing them as either poorly labeled and under represented or well represented and overfitted. We prioritize under represented samples as the main gradient contributors in a minibatch and keep them from the negative influences of poorly labeled or overfitted samples with a mixed-order minibatch sampling design.

cs.CV↗

arXiv2025

Physics-informed machine learning for building performance simulation-A review of a nascent field

Building performance simulation (BPS) is critical for understanding building dynamics and behavior, analyzing performance of the built environment, optimizing energy efficiency, improving demand flexibility, and enhancing building resilience. However, conducting BPS is not trivial. Traditional BPS relies on an accurate building energy model, mostly physics-based, which depends heavily on detailed building information, expert knowledge, and case-by-case model calibrations, thereby significantly limiting their scalability. With the development of sensing technology and increased data availability, there is a growing attention and interest in data-driven BPS. However, purely data-driven models often suffer from limited generalization ability and a lack of physical consistency, resulting in poor performance in real-world applications. To address these limitations, recent studies have started to incorporate physics priors into data-driven models, a methodology called physics-informed machine learning (PIML). PIML is an emerging field with the definitions, methodologies, evaluation criteria, application scenarios, and future directions that remain open. To bridge those gaps, this study systematically reviews the state-of-art PIML for BPS, offering a comprehensive definition of PIML, and comparing it to traditional BPS approaches regarding data requirements, modeling effort, performance and computation cost. We also summarize the commonly used methodologies, validation approaches, application domains, available data sources, open-source packages and testbeds. In addition, this study provides a general guideline for selecting appropriate PIML models based on BPS applications. Finally, this study identifies key challenges and outlines future research directions, providing a solid foundation and valuable insights to advance R&D of PIML in BPS.

eess.SY↗

arXiv2025

DIMM: Decoupled Multi-hierarchy Kalman Filter for 3D Object Tracking

State estimation is challenging for 3D object tracking with high maneuverability, as the target's state transition function changes rapidly, irregularly, and is unknown to the estimator. Existing work based on interacting multiple model (IMM) achieves more accurate estimation than single-filter approaches through model combination, aligning appropriate models for different motion modes of the target object over time. However, two limitations of conventional IMM remain unsolved. First, the solution space of the model combination is constrained as the target's diverse kinematic properties in different directions are ignored. Second, the model combination weights calculated by the observation likelihood are not accurate enough due to the measurement uncertainty. In this paper, we propose a novel framework, DIMM, to effectively combine estimates from different motion models in each direction, thus increasing the 3D object tracking accuracy. First, DIMM extends the model combination solution space of conventional IMM from a hyperplane to a hypercube by designing a 3D-decoupled multi-hierarchy filter bank, which describes the target's motion with various-order linear models. Second, DIMM generates more reliable combination weight matrices through a differentiable adaptive fusion network for importance allocation rather than solely relying on the observation likelihood; it contains an attention-based twin delayed deep deterministic policy gradient (TD3) method with a hierarchical reward. Experiments demonstrate that DIMM significantly improves the tracking accuracy of existing state estimation methods by 31.61%~99.23%.

cs.CV↗

arXiv2025

DS-ProGen: A Dual-Structure Deep Language Model for Functional Protein Design

Inverse Protein Folding (IPF) is a critical subtask in the field of protein design, aiming to engineer amino acid sequences capable of folding correctly into a specified three-dimensional (3D) conformation. Although substantial progress has been achieved in recent years, existing methods generally rely on either backbone coordinates or molecular surface features alone, which restricts their ability to fully capture the complex chemical and geometric constraints necessary for precise sequence prediction. To address this limitation, we present DS-ProGen, a dual-structure deep language model for functional protein design, which integrates both backbone geometry and surface-level representations. By incorporating backbone coordinates as well as surface chemical and geometric descriptors into a next-amino-acid prediction paradigm, DS-ProGen is able to generate functionally relevant and structurally stable sequences while satisfying both global and local conformational constraints. On the PRIDE dataset, DS-ProGen attains the current state-of-the-art recovery rate of 61.47%, demonstrating the synergistic advantage of multi-modal structural encoding in protein design. Furthermore, DS-ProGen excels in predicting interactions with a variety of biological partners, including ligands, ions, and RNA, confirming its robust functional retention capabilities.

cs.CL↗