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Jianqing Zheng

Publications and source records attributed to Jianqing Zheng.

3 recordsLinked to original sources

Forensic Reserve: Eliciting Latent Knowledge for Image Forgery Detection

As generated images become increasingly realistic, reliable forgery detection is essential for maintaining trust in visual information. However, existing methods primarily rely on task-specific supervision to adapt vision foundation model representations, without fully exploiting internal forensic knowledge to guide detection. To address this limitation, we propose Reserve-Guided Elicitation (RGE), a framework that treats sparse, origin-sensitive internal components in pretrained models as a forensic reserve and translates their localization into structural constraints for lightweight adaptation. Specifically, we first use the Forensic Lens (F-lens) to decompose activations across layers and token groups into independent components and globally screen them by their response differences between real and generated images, identifying reserve sites and directions. Next, we map the selected directions back to hidden-state space to construct fixed reserve subspaces and insert Forensic Reserve Adapters (FRA) only at the identified sites. Finally, with the backbone parameters, previously fitted reference classifier, and subspace bases fixed, we train only the FRA coefficient maps to generate input-dependent residual updates constrained to the corresponding subspaces, strengthening existing forensic responses. Using only 500 labeled training images and a trainable parameter budget below 0.2% of the backbone, RGE achieves competitive performance across three detection benchmarks without target-benchmark adaptation. Furthermore, RGE consistently improves over the corresponding frozen detectors across eight encoders spanning self-supervised and vision-language pretraining, eliciting a latent forensic capacity broadly shared across pretrained vision models.

cs.CV↗

Multimodal reasoning for broadly neutralizing antibody discovery from label-free human B cell repertoires across virus families

Discovering broadly neutralizing antibodies (bnAbs) from human natural immune repertoires remains a fundamental challenge in immunology, hindered by: the extreme rarity of bnAb, incomplete understanding of their cellular origins across pathogens, and the inability of existing computational tools to generalize across emerging viral threats. Here we present ImmuneAgent, a closed-loop AI system that integrates multimodal reasoning with continual meta-learning and wet-lab feedback to overcome these barriers. Applied to screen the natural BCR repertoires from vaccinated or infected cohorts, the system achieves a ~55% neutralization antibody discovery rate (60 of 110 cloned candidates) and a ~11% bnAb yield (12 of 110), substantially outperforming a state-of-the-art sequence-based neutralization predictor or cofolding models evaluated at the same cloning budget. Five ImmuneAgent-discovered antibodies conferred 100% in vivo protection against lethal influenza challenge, comparable to the clinical-stage therapeutic MEDI8852. The system recovered the cellular and structural determinants of bnAb activity and identified FCRL5+CD27+ atypical memory B cells as a conserved bnAb reservoir and hydrophobic interface enrichment as a cross-viral structural signature, which generalized to unseen antigens, discovering human metapneumovirus (hMPV) cross-neutralizing and human papillomavirus (HPV)-neutralizing antibodies without antigen-specific sorting. These results validate that ImmuneAgent is a generalizable framework for rapid therapeutic antibody discovery against emerging viral threats.

q-bio.QM↗

Self-Supervised Generative Adversarial Network for Depth Estimation in Laparoscopic Images

Dense depth estimation and 3D reconstruction of a surgical scene are crucial steps in computer assisted surgery. Recent work has shown that depth estimation from a stereo images pair could be solved with convolutional neural networks. However, most recent depth estimation models were trained on datasets with per-pixel ground truth. Such data is especially rare for laparoscopic imaging, making it hard to apply supervised depth estimation to real surgical applications. To overcome this limitation, we propose SADepth, a new self-supervised depth estimation method based on Generative Adversarial Networks. It consists of an encoder-decoder generator and a discriminator to incorporate geometry constraints during training. Multi-scale outputs from the generator help to solve the local minima caused by the photometric reprojection loss, while the adversarial learning improves the framework generation quality. Extensive experiments on two public datasets show that SADepth outperforms recent state-of-the-art unsupervised methods by a large margin, and reduces the gap between supervised and unsupervised depth estimation in laparoscopic images.

eess.IV↗