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Jinman Kim

Publications and source records attributed to Jinman Kim.

At least 19 recordsLinked to original sources

CoMLP: Cooperatively-Gated MLPs for Fine-Grained Cross-Modal Information Fusion in Medical Image Segmentation

Multi-modal medical images and clinical reports provide complementary anatomical, functional, and semantic information for medical image segmentation. Effectively exploiting these heterogeneous sources requires fine-grained cross-modal information fusion that preserves subtle spatial details while capturing semantic dependencies across modalities. Existing fusion approaches frequently rely on cross-attention, whose computational burden increases rapidly with spatial resolution, making dense cross-modal interaction difficult on high-resolution feature maps, particularly for volumetric medical images. In this work, we propose CoMLP, a cooperatively-gated MLP module for fine-grained cross-modal information fusion in medical image segmentation. CoMLP models cross-modal dependencies through cooperative cross-gating, built upon complementary regional and dilated MLP interactions, to capture local and global cross-modal dependencies. We further develop a multi-source fusion architecture in which CoMLP performs both inter-image fusion across imaging modalities and vision-language fusion between visual features and textual reports, enabling heterogeneous information to be integrated without relying on dense cross-attention. Extensive experiments on five medical segmentation benchmarks, covering 2D/3D images, clinical reports, multiple imaging modalities, and diverse anatomical regions, demonstrate consistent improvements over state-of-the-art multi-modal and language-guided segmentation methods. Ablation studies further show that fine-grained interaction at high spatial resolutions and complementary local-global fusion are critical to the performance gains. These results demonstrate the potential of MLP-based interaction as an effective alternative for fine-grained cross-modal information fusion in medical image segmentation.

cs.CV

Heterogeneity-Aware Deep Learning for Tumour Classification from Multiparametric MRI

Intra-tumoural heterogeneity (ITH) reflects spatial variation in tumour biology and is an important determinant of tumour behaviour, prognosis, and treatment response. Radiomics and deep learning have shown promise for tumour classification from multiparametric MRI (mp-MRI), but radiomics relies on handcrafted features, while most deep learning methods use whole-tumour representations or manually defined sub-regions, limiting scalable modelling of tumour heterogeneity. We propose a Heterogeneity-Aware Deep Learning Classification (HA-DLC) framework that explicitly models imaging-derived tumour sub-regions for lesion-type diagnosis and molecular-status prediction. HA-DLC consists of: (1) a Heterogeneous Sub-region Generation (HSG) module that produces initial pseudo-labelled sub-regions via unsupervised clustering, followed by Cross-Patient Sub-region Alignment (CPSA), which maps cluster-derived regions to a shared label space using soft assignments; and (2) a Dual-Stream Feature Extraction (DSFE) module that integrates local heterogeneity-aware features with global tumour representations. Given the initial clustering masks, CPSA, segmentation, feature extraction, and classification are jointly optimized end-to-end using soft-target segmentation and classification objectives. We evaluate HA-DLC on the LLD-MMRI2023 liver lesion dataset and the RSNA-ASNR-MICCAI 2021 Radiogenomic Brain Tumour dataset. HA-DLC consistently outperforms state-of-the-art radiomics and deep learning baselines, demonstrating the value of cross-patient sub-region alignment and dual-stream heterogeneity modelling for tumour classification from mp-MRI.

cs.CV

ImProNCDE: Impulse-Corrected Neural Controlled Differential Equations with Prototype Learning for Longitudinal Prognosis Prediction

Longitudinal ophthalmic imaging analysis is an essential step for prognosis prediction in ophthalmic diseases. However, AI-assisted prognosis models are challenged by follow-up sequences, which tend to be sparse, irregularly sampled, and incomplete. Although advanced prognosis modeling methods, especially for the methods based on neural controlled differential equations (NCDEs), provide a principled continuous-time framework for sparse and irregular longitudinal data. Unfortunately, two major concerns remain unsolved in clinical follow-up modeling. First, the smooth latent dynamics of standard NCDEs is poorly matched to abrupt pathological changes induced by therapeutic intervention, lesion recurrence, or long follow-up gaps. Second, numerical integration over long horizons can accumulate errors, which will produce unstable latent trajectories and weakened class discrimination. To address these challenges, we propose ImProNCDE, an impulse-corrected NCDE framework with prototype learning for longitudinal ophthalmic prognosis prediction. To capture abrupt pathological changes beyond smooth latent dynamics, ImProNCDE introduces Residual Impulse Calibration (RIC), which injects residual-based impulse corrections at visit times and then recalibrates the latent state when observations deviate from continuous predictions. To further mitigate error accumulation over long horizons, we introduce a Prototype-guided Trajectory Stabilizer (PTS), which aims to attract latent trajectories toward learnable prognosis prototypes to reduce class overlap and which ultimately improves long-horizon stability. Experiments on multiple private and public longitudinal ophthalmic datasets (totalling over 1206 samples) show that ImProNCDE outperforms existing SOTA methods focusing on sequence modeling.

cs.CE

DiffSight-Former: Modeling Structural Differences and Temporal Dynamics for Glaucoma Progression Prediction

Glaucoma is a leading cause of irreversible blindness worldwide, and early detection from fundus images is critical for effective disease management. While deep learning has achieved promising performance in fundus image analysis, most existing methods rely on single time-point images and fail to capture longitudinal structural and vascular changes associated with disease progression. Sequential fundus images acquired during clinical follow-up provide valuable temporal information; however, current sequential models often struggle to detect subtle early progression signals and commonly depend on fixed-length inputs or diagnostic cues from already glaucomatous images, limiting their clinical utility for early prediction. To address these limitations, we propose DiffSight-Former, a framework for glaucoma progression prediction from sequential fundus images. It incorporates a time-variant feature extraction module based on a fundus-specific foundation model to obtain robust anatomical representations. A multi-structure difference modeling module is introduced to quantify progression-related changes in the optic disc/cup region and retinal vasculature. These representations are integrated with temporal interval embeddings and processed by a time-aware Transformer to model disease progression and estimate the probability of future glaucoma onset. Experiments were conducted on two longitudinal datasets, SIGF (405 sequences) and GRAPE (263 sequences). On SIGF, DiffSight-Former achieved an AUC of 91.54% and a sensitivity of 92.16% for progression prediction. On GRAPE, it achieved an average accuracy of 87.48% across three clinical visual-field progression criteria. Compared with existing approaches, DiffSight-Former demonstrates strong performance and robustness across different temporal settings, highlighting its potential for longitudinal glaucoma monitoring and early risk prediction.

cs.CV

EasyLens: A Training-Free Plug-and-Play Subtle-Lesion Representation Amplifier for Medical Vision-Language Models

Medical vision-language models (VLMs) have shown increasing potential for clinical image interpretation, including lesion detection and report generation. However, their practical utility remains limited by insufficient sensitivity to subtle lesions, whose visual evidence is often sparse, low-contrast, and embedded within complex anatomical context. As local visual tokens are aggregated, these weak lesion cues can become underrepresented in global image representations, making them difficult for medical VLMs to recognize. Existing efforts to improve lesion sensitivity mainly rely on medical-domain vision-encoder pre-training, clinical-term-guided alignment, or trainable pathological representation enhancement. Although effective, these approaches usually require additional training or model-specific adaptation and may overfit to particular disease morphologies, limiting their applicability to frozen medical VLMs. To address these limitations, we propose EasyLens, a training-free plug-and-play subtle-lesion representation amplifier for medical VLMs. EasyLens first constructs EasyBank, a pathology-anatomy prototype space that provides lesion-related prototypes and anatomy-aware normal references for comparing suspicious patches against both pathological and normal anatomical patterns. To avoid blindly amplifying normal tissues, EasyTag selects lesion-relevant patches through counterfactual prototype reasoning. To counteract the dilution of subtle lesion cues in global image representations, EasyAmplifier strengthens the selected lesion-relevant patch representations through morphology-guided residual enhancement, thereby increasing their contribution to the global image embedding. Experiments on multiple medical image datasets and frozen medical VLM backbones show that EasyLens improves subtle-lesion detection and outperforms existing encoder-enhancement baselines.

cs.CV

HyDAR-Pano3D: A Hybrid Disentangled Anatomical Recovery Framework for Panoramic-to-3D Reconstruction

Panoramic radiograph (PR) is fundamentally used in routine dental care, but it inherently provides only a two-dimensional (2D) projection of complex three-dimensional (3D) craniofacial anatomy. Most existing learning-based methods attempt to computationally recover this 3D information by directly regressing native cone-beam computed tomography (CBCT) volumes from PR. However, this direct mapping requires the model to simultaneously learn common anatomical structures and patient-specific morphological variations. This entangled formulation makes the ill-posed 2D-to-3D inverse problem highly ambiguous, often producing over-smoothed reconstructions with blurred anatomical boundaries. To address this, we propose HyDAR-Pano3D, a two-stage framework that reformulates PR-to-CBCT reconstruction as a disentangled anatomical recovery problem. In Stage 1, a dual-encoder network integrates radiographic features with SAM-derived semantic priors to reconstruct an arch-normalized canonical volume. In Stage 2, an Anatomical Restoration Network predicts a prior-constrained structured deformation field to map this canonical volume back to the native space, restoring individual morphological variations. Experiments on three large-scale datasets show that HyDAR-Pano3D significantly outperforms baseline methods ($p < 0.05$), achieving a 25.76 dB PSNR, 85.70\% SSIM, and an 83.83\% overall anatomical Dice score. The synthesized volumes successfully support downstream segmentation of whole teeth (82.4\% Dice) and the inferior alveolar canal (72.2\% Dice), demonstrating that our disentangled approach preserves clinically relevant structures to enable robust anatomy-aware assessment when CBCT data is unavailable.

cs.CV

RadGenome-Anatomy: A Large-Scale Anatomy-Labeled Chest Radiograph Dataset via Physically Grounded Volumetric Projection

Anatomical structure labels for chest radiographs are essential for medical image segmentation and a broad range of downstream diagnostic tasks. However, annotating anatomy directly on 2D chest radiographs is labor-intensive and intrinsically ambiguous, as 3D anatomical structures are projected onto a single 2D plane where boundaries may overlap, be occluded, or appear only partially visible. Consequently, existing anatomy-labeled chest radiograph datasets remain limited in scale, anatomy coverage, and label reliability. To address these limitations, we introduce RadGenome-Anatomy, the largest anatomy-labeled chest radiograph dataset, containing over 10 million segmentation masks across 210 anatomical structures in 25,692 studies. It is constructed by projecting large-scale 3D anatomical masks from CT volumes into 2D radiographic space through canonical radiographic geometry. This shifts annotation from directly tracing uncertain 2D boundaries to defining anatomy in volumetric space, where structures that overlap or become partially invisible in radiographs remain spatially separable. As a result, each 2D mask represents the physically grounded projected footprint of a volumetrically defined structure. The scale and broad anatomical coverage of RadGenome-Anatomy, including structures that are overlapping, partially visible, or difficult to delineate directly, enable research on geometric measurements as explicit evidence for chest radiograph interpretation. We demonstrate this by training XAnatomy to predict structure-specific masks and derive clinically relevant measurements, achieving diagnostic accuracies of 96.4%, 95.6%, and 89.2% for cardiomegaly, kyphosis, and scoliosis, respectively.

cs.CV

CBT-Audio: Evaluating Audio Language Models for Patient-Side Distress Intensity Estimation in CBT Session Recordings

Cognitive behavioural therapy is widely used to help patients understand and manage psychological distress. It is often delivered through spoken conversation, where therapists attend not only to what patients say, but also to how they say it, because these cues can help therapists decide how to respond and adapt treatment. Progress in building AI systems for CBT remains largely limited to text, partly because most available datasets are text based and shareable spoken CBT data are scarce under ethical and privacy constraints. This creates a blind spot because text based models and evaluations cannot capture the mismatch between the transcript and the patient's voice, even though therapists often rely on this mismatch to understand patient distress. We introduce CBT-Audio, a dataset for evaluating patient distress estimation from spoken CBT sessions with audio language models. CBT-Audio contains 1,802 patient turns from 96 publicly available CBT recordings, with turn-level distress labels validated on an experts-annotated subset. We evaluate 10 open source audio language models under three input conditions, where models receive only patient audio, only the transcript, or both audio and transcript. Our results show that audio can provide useful information beyond text, especially when combined with transcripts. Adding audio to transcript input improves distress estimation over using the transcript alone in 8 of 10 model families, with significant gains in 4, and case studies show the clearest benefit when verbal content and vocal delivery diverge. CBT-Audio makes spoken patient behaviour measurable for AI evaluation in CBT-related tasks and supports future work on audio language models for mental health interaction.

cs.AI

Patient4D: Temporally Consistent Patient Body Mesh Recovery from Monocular Operating Room Video

Recovering a dense 3D body mesh from monocular video remains challenging under occlusion from draping and continuously moving camera viewpoints. This configuration arises in surgical augmented reality (AR), where an anesthetized patient lies under surgical draping while a surgeon's head-mounted camera continuously changes viewpoint. Existing human mesh recovery (HMR) methods are typically trained on upright, moving subjects captured from relatively stable cameras, leading to performance degradation under such conditions. To address this, we present Patient4D, a stationarity-constrained reconstruction pipeline that explicitly exploits the stationarity prior. The pipeline combines image-level foundation models for perception with lightweight geometric mechanisms that enforce temporal consistency across frames. Two key components enable robust reconstruction: Pose Locking, which anchors pose parameters using stable keyframes, and Rigid Fallback, which recovers meshes under severe occlusion through silhouette-guided rigid alignment. Together, these mechanisms stabilize predictions while remaining compatible with off-the-shelf HMR models. We evaluate Patient4D on 4,680 synthetic surgical sequences and three public HMR video benchmarks. Under surgical drape occlusion, Patient4D achieves a 0.75 mean IoU, reducing failure frames from 30.5% to 1.3% compared to the best baseline. Our findings demonstrate that exploiting stationarity priors can substantially improve monocular reconstruction in clinical AR scenarios.

cs.CV

Beyond Calibration: Confounding Pathology Limits Foundation Model Specificity in Abdominal Trauma CT

Purpose: Translating foundation models into clinical practice requires evaluating their performance under compound distribution shift, where severe class imbalance coexists with heterogeneous imaging appearances. This challenge is relevant for traumatic bowel injury, a rare but high-mortality diagnosis. We investigated whether specificity deficits in foundation models are associated with heterogeneity in the negative class. Methods: This retrospective study used the multi-institutional, RSNA Abdominal Traumatic Injury CT dataset (2019-2023), comprising scans from 23 centres. Two foundation models (MedCLIP, zero-shot; RadDINO, linear probe) were compared against three task-specific approaches (CNN, Transformer, Ensemble). Models were trained on 3,147 patients (2.3% bowel injury prevalence) and evaluated on an enriched 100-patient test set. To isolate negative-class effects, specificity was assessed in patients without bowel injury who had concurrent solid organ injury (n=58) versus no abdominal pathology (n=50). Results: Foundation models achieved equivalent discrimination to task-specific models (AUC, 0.64-0.68 versus 0.58-0.64) with higher sensitivity (79-91% vs 41-74%) but lower specificity (33-50% vs 50-88%). All models demonstrated high specificity in patients without abdominal pathology (84-100%). When solid organ injuries were present, specificity declined substantially for foundation models (50-51 percentage points) compared with smaller reductions of 12-41 percentage points for task-specific models. Conclusion: Foundation models matched task-specific discrimination without task-specific training, but their specificity deficits were driven primarily by confounding negative-class heterogeneity rather than prevalence alone. Susceptibility to negative-class heterogeneity decreased progressively with labelled training, suggesting adaptation is required before clinical implementation.

eess.IV

HyperWalker: Dynamic Hypergraph-Based Deep Diagnosis for Multi-Hop Clinical Modeling across EHR and X-Ray in Medical VLMs

Automated clinical diagnosis remains a core challenge in medical AI, which usually requires models to integrate multi-modal data and reason across complex, case-specific contexts. Although recent methods have advanced medical report generation (MRG) and visual question answering (VQA) with medical vision-language models (VLMs), these methods, however, predominantly operate under a sample-isolated inference paradigm, as such processing cases independently without access to longitudinal electronic health records (EHRs) or structurally related patient examples. This paradigm limits reasoning to image-derived information alone, which ignores external complementary medical evidence for potentially more accurate diagnosis. To overcome this limitation, we propose \textbf{HyperWalker}, a \textit{Deep Diagnosis} framework that reformulates clinical reasoning via dynamic hypergraphs and test-time training. First, we construct a dynamic hypergraph, termed \textbf{iBrochure}, to model the structural heterogeneity of EHR data and implicit high-order associations among multimodal clinical information. Within this hypergraph, a reinforcement learning agent, \textbf{Walker}, navigates to and identifies optimal diagnostic paths. To ensure comprehensive coverage of diverse clinical characteristics in test samples, we incorporate a \textit{linger mechanism}, a multi-hop orthogonal retrieval strategy that iteratively selects clinically complementary neighborhood cases reflecting distinct clinical attributes. Experiments on MRG with MIMIC and medical VQA on EHRXQA demonstrate that HyperWalker achieves state-of-the-art performance. Code is available at: https://github.com/Bean-Young/HyperWalker

cs.CL

MRG-R1: Reinforcement Learning for Clinically Aligned Medical Report Generation

Medical report generation aims to automatically produce radiology-style reports from medical images, supporting efficient and accurate clinical decision-making.However, existing approaches predominately rely on token-level likelihood training, which favors local lexical matching and leaves clinical correctness under-specified in the training objective. This behavior can be attributed to token-level likelihood optimization, which rewards surface-form agreement and therefore fails to directly encode constraints on medically accurate findings. To address this objective mismatch, we introduce a semantic-driven reinforcement learning (SRL) framework for medical report generation, named MRG-R1, which directly optimizes report-level clinical correctness rather than token-level likelihood. The key module is a clinically grounded report-level reward function, which reinforces semantic agreement in clinically relevant findings between generated and reference reports, thereby enabling learning signals that explicitly constrain medical correctness beyond surface linguistic alignment. Our evaluations show that the proposed framework improves the accuracy and coverage of clinically relevant findings in generated reports, and that MRG-R1 achieves state-of-the-art clinical efficacy on the IU X-Ray and MIMIC-CXR benchmark datasets.

cs.CL

Intersectional Fairness in Vision-Language Models for Medical Image Disease Classification

Medical artificial intelligence (AI) systems, particularly multimodal vision-language models (VLM), often exhibit intersectional biases where models are systematically less confident in diagnosing marginalised patient subgroups. Such bias can lead to higher rates of inaccurate and missed diagnoses due to demographically skewed data and divergent distributions of diagnostic certainty. Current fairness interventions frequently fail to address these gaps or compromise overall diagnostic performance to achieve statistical parity among the subgroups. In this study, we developed Cross-Modal Alignment Consistency (CMAC-MMD), a training framework that standardises diagnostic certainty across intersectional patient subgroups. Unlike traditional debiasing methods, this approach equalises the model's decision confidence without requiring sensitive demographic data during clinical inference. We evaluated this approach using 10,015 skin lesion images (HAM10000) with external validation on 12,000 images (BCN20000), and 10,000 fundus images for glaucoma detection (Harvard-FairVLMed), stratifying performance by intersectional age, gender, and race attributes. In the dermatology cohort, the proposed method reduced the overall intersectional missed diagnosis gap (difference in True Positive Rate, $\Delta$TPR) from 0.50 to 0.26 while improving the overall Area Under the Curve (AUC) from 0.94 to 0.97 compared to standard training. Similarly, for glaucoma screening, the method reduced $\Delta$TPR from 0.41 to 0.31, achieving a better AUC of 0.72 (vs. 0.71 baseline). This establishes a scalable framework for developing high-stakes clinical decision support systems that are both accurate and can perform equitably across diverse patient subgroups, ensuring reliable performance without increasing privacy risks.

cs.CV

A novel language model for predicting serious adverse event results in clinical trials from their prospective registrations

Objectives: With accurate estimates of expected safety results, clinical trials could be better designed and monitored. We evaluated methods for predicting serious adverse event (SAE) results in clinical trials using information only from their registrations prior to the trial. Material and Methods: We analyzed 22,107 two-arm parallel interventional clinical trials from ClinicalTrials.gov with structured summary results. Two prediction models were developed: a classifier predicting whether a greater proportion of participants in an experimental arm would have SAEs (area under the receiver operating characteristic curve; AUC) compared to the control arm, and a regression model to predict the proportion of participants with SAEs in the control arms (root mean squared error; RMSE). A transfer learning approach using pretrained language models (e.g., ClinicalT5, BioBERT) was used for feature extraction, combined with a downstream model for prediction. To maintain semantic representation in long trial texts exceeding localized language model input limits, a sliding window method was developed for embedding extraction. Results: The best model (ClinicalT5+Transformer+MLP) had 77.6% AUC when predicting which trial arm had a higher proportion of SAEs. When predicting SAE proportion in the control arm, the same model achieved RMSE of 18.6%. The sliding window approach consistently outperformed direct comparisons. Across 12 classifiers, the average absolute AUC increase was 2.00%, and absolute RMSE reduction was 1.58% across 12 regressors. Discussion: Summary results data from ClinicalTrials.gov remains underutilized. Predicted results of publicly reported trials provides an opportunity to identify discrepancies between expected and reported safety results.

cs.CL

Alleviating Textual Reliance in Medical Language-guided Segmentation via Prototype-driven Semantic Approximation

Medical language-guided segmentation, integrating textual clinical reports as auxiliary guidance to enhance image segmentation, has demonstrated significant improvements over unimodal approaches. However, its inherent reliance on paired image-text input, which we refer to as ``textual reliance", presents two fundamental limitations: 1) many medical segmentation datasets lack paired reports, leaving a substantial portion of image-only data underutilized for training; and 2) inference is limited to retrospective analysis of cases with paired reports, limiting its applicability in most clinical scenarios where segmentation typically precedes reporting. To address these limitations, we propose ProLearn, the first Prototype-driven Learning framework for language-guided segmentation that fundamentally alleviates textual reliance. At its core, we introduce a novel Prototype-driven Semantic Approximation (PSA) module to enable approximation of semantic guidance from textual input. PSA initializes a discrete and compact prototype space by distilling segmentation-relevant semantics from textual reports. Once initialized, it supports a query-and-respond mechanism which approximates semantic guidance for images without textual input, thereby alleviating textual reliance. Extensive experiments on QaTa-COV19, MosMedData+ and Kvasir-SEG demonstrate that ProLearn outperforms state-of-the-art language-guided methods when limited text is available.

cs.CV

MRGAgents: A Multi-Agent Framework for Improved Medical Report Generation with Med-LVLMs

Medical Large Vision-Language Models (Med-LVLMs) have been widely adopted for medical report generation. Despite Med-LVLMs producing state-of-the-art performance, they exhibit a bias toward predicting all findings as normal, leading to reports that overlook critical abnormalities. Furthermore, these models often fail to provide comprehensive descriptions of radiologically relevant regions necessary for accurate diagnosis. To address these challenges, we proposeMedical Report Generation Agents (MRGAgents), a novel multi-agent framework that fine-tunes specialized agents for different disease categories. By curating subsets of the IU X-ray and MIMIC-CXR datasets to train disease-specific agents, MRGAgents generates reports that more effectively balance normal and abnormal findings while ensuring a comprehensive description of clinically relevant regions. Our experiments demonstrate that MRGAgents outperformed the state-of-the-art, improving both report comprehensiveness and diagnostic utility.

cs.MA

MedCFVQA: A Causal Approach to Mitigate Modality Preference Bias in Medical Visual Question Answering

Medical Visual Question Answering (MedVQA) is crucial for enhancing the efficiency of clinical diagnosis by providing accurate and timely responses to clinicians' inquiries regarding medical images. Existing MedVQA models suffered from modality preference bias, where predictions are heavily dominated by one modality while overlooking the other (in MedVQA, usually questions dominate the answer but images are overlooked), thereby failing to learn multimodal knowledge. To overcome the modality preference bias, we proposed a Medical CounterFactual VQA (MedCFVQA) model, which trains with bias and leverages causal graphs to eliminate the modality preference bias during inference. Existing MedVQA datasets exhibit substantial prior dependencies between questions and answers, which results in acceptable performance even if the model significantly suffers from the modality preference bias. To address this issue, we reconstructed new datasets by leveraging existing MedVQA datasets and Changed their P3rior dependencies (CP) between questions and their answers in the training and test set. Extensive experiments demonstrate that MedCFVQA significantly outperforms its non-causal counterpart on both SLAKE, RadVQA and SLAKE-CP, RadVQA-CP datasets.

cs.CV

MAISY: Motion-Aware Image SYnthesis for Medical Image Motion Correction

Patient motion during medical image acquisition causes blurring, ghosting, and distorts organs, which makes image interpretation challenging. Current state-of-the-art algorithms using Generative Adversarial Network (GAN)-based methods with their ability to learn the mappings between corrupted images and their ground truth via Structural Similarity Index Measure (SSIM) loss effectively generate motion-free images. However, we identified the following limitations: (i) they mainly focus on global structural characteristics and therefore overlook localized features that often carry critical pathological information, and (ii) the SSIM loss function struggles to handle images with varying pixel intensities, luminance factors, and variance. In this study, we propose Motion-Aware Image SYnthesis (MAISY) which initially characterize motion and then uses it for correction by: (a) leveraging the foundation model Segment Anything Model (SAM), to dynamically learn spatial patterns along anatomical boundaries where motion artifacts are most pronounced and, (b) introducing the Variance-Selective SSIM (VS-SSIM) loss which adaptively emphasizes spatial regions with high pixel variance to preserve essential anatomical details during artifact correction. Experiments on chest and head CT datasets demonstrate that our model outperformed the state-of-the-art counterparts, with Peak Signal-to-Noise Ratio (PSNR) increasing by 40%, SSIM by 10%, and Dice by 16%.

eess.IV