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arXiv2022

Multi-modal Brain Tumor Segmentation via Missing Modality Synthesis and Modality-level Attention Fusion

Multi-modal magnetic resonance (MR) imaging provides great potential for diagnosing and analyzing brain gliomas. In clinical scenarios, common MR sequences such as T1, T2 and FLAIR can be obtained simultaneously in a single scanning process. However, acquiring contrast enhanced modalities such as T1ce requires additional time, cost, and injection of contrast agent. As such, it is clinically meaningful to develop a method to synthesize unavailable modalities which can also be used as additional inputs to downstream tasks (e.g., brain tumor segmentation) for performance enhancing. In this work, we propose an end-to-end framework named Modality-Level Attention Fusion Network (MAF-Net), wherein we innovatively conduct patchwise contrastive learning for extracting multi-modal latent features and dynamically assigning attention weights to fuse different modalities. Through extensive experiments on BraTS2020, our proposed MAF-Net is found to yield superior T1ce synthesis performance (SSIM of 0.8879 and PSNR of 22.78) and accurate brain tumor segmentation (mean Dice scores of 67.9%, 41.8% and 88.0% on segmenting the tumor core, enhancing tumor and whole tumor).

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arXiv2022

Unsupervised Domain Adaptation for Cross-Modality Retinal Vessel Segmentation via Disentangling Representation Style Transfer and Collaborative Consistency Learning

Various deep learning models have been developed to segment anatomical structures from medical images, but they typically have poor performance when tested on another target domain with different data distribution. Recently, unsupervised domain adaptation methods have been proposed to alleviate this so-called domain shift issue, but most of them are designed for scenarios with relatively small domain shifts and are likely to fail when encountering a large domain gap. In this paper, we propose DCDA, a novel cross-modality unsupervised domain adaptation framework for tasks with large domain shifts, e.g., segmenting retinal vessels from OCTA and OCT images. DCDA mainly consists of a disentangling representation style transfer (DRST) module and a collaborative consistency learning (CCL) module. DRST decomposes images into content components and style codes and performs style transfer and image reconstruction. CCL contains two segmentation models, one for source domain and the other for target domain. The two models use labeled data (together with the corresponding transferred images) for supervised learning and perform collaborative consistency learning on unlabeled data. Each model focuses on the corresponding single domain and aims to yield an expertized domain-specific segmentation model. Through extensive experiments on retinal vessel segmentation, our framework achieves Dice scores close to target-trained oracle both from OCTA to OCT and from OCT to OCTA, significantly outperforming other state-of-the-art methods.

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