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Long Bai

Publications and source records attributed to Long Bai.

At least 37 records · Page 2Linked to original sources

DaX: Learning General Pathology Representations Across Scales

Computational pathology requires visual representations that transfer across diverse clinical endpoints and remain robust to variation in magnification, staining, scanner type, slide preparation, and input resolution. We present DaX, a pathology vision foundation model that adapts DINOv3-style self-supervised learning to whole-slide histopathology. DaX is initialized from natural-image DINOv3 weights and incorporates continuous magnification training, cross-scale tissue views, orientation-agnostic and acquisition-robust augmentation, multi-input-size training, and Gram-anchored dense consistency. These designs aim to connect local cellular morphology with global tissue architecture while stabilizing dense token-level representations across input scales. We further construct a WSI-level benchmark comprising 161 clinically meaningful tasks from 44 public datasets, covering 28,182 patients and 34,394 slides across four clinical domains and nine task categories. All models are evaluated under a fixed patient-level cross-validation protocol with fold-level statistical ranking, enabling reproducible comparisons that are less sensitive to split-dependent variation. Across this benchmark, DaX achieves the highest mean performance across tasks and consistently strong task-level ranking scores, with gains spanning diagnostic pathology, biomarker and molecular profiling, tissue/specimen context, and risk, response, and prognosis. These results support DaX as a transferable visual encoder for computational pathology and provide a standardized evaluation framework for future pathology foundation models. Project page: https://alibaba-damo-academy.github.io/DaX/benchboard/.

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Code-on-Graph: Iterative Programmatic Reasoning via Large Language Models on Knowledge Graphs

Knowledge Graphs (KGs) are widely used to mitigate the limitations of Large Language Models (LLMs), such as outdated knowledge and hallucinations. Existing LLM-KG integration frameworks typically rely on predefined operators to retrieve factual knowledge from KGs and inject it into prompts for answer generation. This paradigm faces two critical bottlenecks: 1) Inflexibility: The predefined operators are limited in scope and thus lack sufficient compositional expressiveness to fully capture the complex semantics required by KG questions. 2) Unscalability: Direct injection of factual knowledge into prompts limits scalability in handling large-scale factual knowledge. To address these two bottlenecks, we propose Code-on-Graph (CoG), a programmatic reasoning framework for LLM-KG integration. Specifically, given the factual knowledge retrieved at each reasoning step, CoG first identifies the corresponding KG schemas and represents these schemas as Python classes, which serve as abstract interfaces to the retrieved facts. It then generates executable code grounded in these classes, with the retrieved facts instantiated as objects of the corresponding classes during execution. This design enables flexible code-based reasoning while avoiding the direct injection of large-scale factual knowledge into prompts. Experiments on WebQSP, CWQ, and GrailQA demonstrate that CoG outperforms prior state-of-the-art models by up to 10.5%.

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Benchmarking Pathology Foundation Models for Spatial Domain Understanding

Pathology foundation models (PFMs) have emerged as a core approach for learning transferable representations from whole slide images (WSIs), and they are typically benchmarked through downstream clinical endpoints. While such task level evaluations are indispensable, they offer limited insight into what the representations themselves encode, particularly whether PFM embeddings can distinguish meaningful tissue regions and capture their spatial relationships. We present SpaPath-Bench, a representation level benchmark designed to diagnose spatial representation capability in PFMs. SpaPath-Bench formulates spatial domain identification (SDI) on paired whole slide image and spatial transcriptomics (ST) data as a diagnostic task. It curates 42 public paired WSI and ST slides, enables large scale evaluation across 19 encoders and seven SDI methods, and measures partition quality using three complementary criteria: unsupervised spatial coherence, transcriptomics referenced agreement, and expert referenced agreement. Across 83K runs, SpaPath-Bench reveals that different pretraining paradigms capture distinct aspects of tissue spatial architecture, and it provides practical guidance for building the next generation of spatially aware computational pathology models. Code and data pipelines are publicly available at https://bokai-zhao.github.io/SpaPath-benchboard/.

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How can reasoning capability empower the AI copilot robot in endoscopic surgery

Reasoning capability has significantly advanced complex logical inference and robotic decision-making in general domains. However, its potential in the Artificial Intelligence (AI) copilot robot-particularly implemented based on the Vision-Language-Action (VLA) model-remains unexplored in endoscopic surgery. Effective reasoning should enable AI copilot robots to integrate multimodal cues, interpret surgical intent, and infer hidden tissue dynamics, thereby alleviating intraoperative uncertainty and cognitive burden on surgeons. Properly implemented, reasoning-driven autonomy can transform AI copilot robots from reactive executors into cognitive collaborators, enhancing precision, safety, and sustainability in clinical practice.

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Intuitive Surgical SurgToolLoc and SurgVU Challenges Results: 2022-2025

Robotic assisted (RA) surgery promises to transform surgical intervention. Intuitive Surgical is committed to fostering these changes and the machine learning models and algorithms that will enable them. With these goals in mind we have invited the surgical data science community to participate in a yearly competition hosted through the Medical Imaging Computing and Computer Assisted Interventions (MICCAI) conference. With varying changes from year to year, we have challenged the community to solve difficult machine learning problems in the context of advanced RA applications. Here we document the results of these challenges, focusing on surgical tool localization (SurgToolLoc) and surgical visual understanding (SurgVU). The publicly released dataset that accompanies these challenges is detailed in a separate paper arXiv:2501.09209 [1].

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EndoGSim: Physics-Aware 4D Dynamic Endoscopic Scene Simulations via MLLM-Guided Gaussian Splatting

In robot-assisted minimally invasive surgery, high-fidelity dynamic endoscopic scene reconstruction and simulation are crucial to enhancing downstream tasks and advancing surgical outcomes. However, existing methods primarily focus on visual reconstruction, lacking physics-based descriptions of the scene required for realistic simulation. We propose a unified framework that achieves physics-aware reconstruction and physical simulation of endoscopic scenes through Multi-modal Large Language Models (MLLMs)-guided Gaussian Splatting. Our approach utilizes 4D Gaussian Splatting (4DGS) integrated with pre-trained segmentation and depth estimation to represent deformable tissues and tools. To achieve automatic inference of physical properties, we introduce an object-wise material field that initializes material parameters via MLLM and refines them through a differentiable Material Point Method (MPM) under joint supervision from rendered images and optical flow. Validated on both open-source and in-house datasets, our framework achieves superior simulation fidelity and physical accuracy compared to state-of-the-art methods, underscoring its potential to advance robot-assisted surgical applications.

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SegSTRONG-C: Segmenting Surgical Tools Robustly On Non-adversarial Generated Corruptions -- An EndoVis'24 Challenge

Surgical data science has seen rapid advancement with the excellent performance of end-to-end deep neural networks (DNNs). Despite their successes, DNNs have been proven susceptible to minor "corruptions," introducing a major concern for the translation of cutting-edge technology, especially in high-stakes scenarios. We introduce the SegSTRONG-C challenge dedicated to better understanding model deterioration under unforeseen but plausible non-adversarial "corruption" and the capabilities of contemporary methods that seek to improve it. Built on a dataset generated through counterfactual robotic replay, SegSTRONG-C provides paired clean and "corrupted" samples, enabling reproducible evaluation of model robustness. Participants are challenged to train tool segmentation algorithms on "uncorrupted" data and evaluate them on "corrupted" test domains for the binary robot tool segmentation task. Through comprehensive baseline experiments and participating submissions from widespread community engagement, SegSTRONG-C reveals key themes for model failure and identifies promising directions for improving robustness. The performance of challenge winners, achieving an average 0.9394 DSC and 0.9301 NSD across the unreleased test sets with "corruption" types: bleeding, smoke, and low brightness. This highlights how prior knowledge, customized training strategies, and architectural choice can be leveraged to improve robustness. In conclusion, the SegSTRONG-C challenge has identified practical approaches for enhancing model robustness. However, most approaches rely on conventional techniques that have known limitations. Looking ahead, we advocate for expanding intellectual diversity and creativity in non-adversarial robustness beyond data augmentation, calling for new paradigms that enhance universal robustness to unforeseen "corruptions" to facilitate richer applications in surgical data science.

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Towards Knowledgeable Deep Research: Framework and Benchmark

Deep Research (DR) requires LLM agents to autonomously perform multi-step information seeking, processing, and reasoning to generate comprehensive reports. In contrast to existing studies that mainly focus on unstructured web content, a more challenging DR task should additionally utilize structured knowledge to provide a solid data foundation, facilitate quantitative computation, and lead to in-depth analyses. In this paper, we refer to this novel task as Knowledgeable Deep Research (KDR), which requires DR agents to generate reports with both structured and unstructured knowledge. Furthermore, we propose the Hybrid Knowledge Analysis framework (HKA), a multi-agent architecture that reasons over both kinds of knowledge and integrates the texts, figures, and tables into coherent multimodal reports. The key design is the Structured Knowledge Analyzer, which utilizes both coding and vision-language models to produce figures, tables, and corresponding insights. To support systematic evaluation, we construct KDR-Bench, which covers 9 domains, includes 41 expert-level questions, and incorporates a large number of structured knowledge resources (e.g., 1,252 tables). We further annotate the main conclusions and key points for each question and propose three categories of evaluation metrics including general-purpose, knowledge-centric, and vision-enhanced ones. Experimental results demonstrate that HKA consistently outperforms most existing DR agents on general-purpose and knowledge-centric metrics, and even surpasses the Gemini DR agent on vision-enhanced metrics, highlighting its effectiveness in deep, structure-aware knowledge analysis. Finally, we hope this work can serve as a new foundation for structured knowledge analysis in DR agents and facilitate future multimodal DR studies.

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TR2M: Transferring Monocular Relative Depth to Metric Depth with Language Descriptions and Dual-Level Scale-Oriented Contrast

This work presents a generalizable framework to transfer relative depth to metric depth. Current monocular depth estimation methods are mainly divided into metric depth estimation (MMDE) and relative depth estimation (MRDE). MMDEs estimate depth in metric scale but are often limited to a specific domain. MRDEs generalize well across different domains, but with uncertain scales which hinders downstream applications. To this end, we aim to build up a framework to solve scale uncertainty and transfer relative depth to metric depth. Previous methods used language as input and estimated two factors for conducting rescaling. Our approach, TR2M, utilizes both text description and image as inputs and estimates two rescale maps to transfer relative depth to metric depth at pixel level. Features from two modalities are fused with a cross-modality attention module to better capture scale information. A strategy is designed to construct and filter confident pseudo metric depth for more comprehensive supervision. We also develop scale-oriented contrastive learning to utilize depth distribution as guidance to enforce the model learning about intrinsic knowledge aligning with the scale distribution. TR2M only exploits a small number of trainable parameters to train on datasets in various domains and experiments not only demonstrate TR2M's great performance in seen datasets but also reveal superior zero-shot capabilities on five unseen datasets. We show the huge potential in pixel-wise transferring relative depth to metric depth with language assistance. (Code is available at: https://github.com/BeileiCui/TR2M)

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Leveling3D: Leveling Up 3D Reconstruction with Feed-Forward 3D Gaussian Splatting and Geometry-Aware Generation

Feed-forward 3D reconstruction has revolutionized 3D vision, providing a powerful baseline for downstream tasks such as novel-view synthesis with 3D Gaussian Splatting. Previous works explore fixing the corrupted rendering results with a diffusion model. However, they lack geometric concern and fail at filling the missing area on the extrapolated view. In this work, we introduce Leveling3D, a novel pipeline that integrates feed-forward 3D reconstruction with geometrical-consistent generation to enable holistic simultaneous reconstruction and generation. We propose a geometry-aware leveling adapter, a lightweight technique that aligns internal knowledge in the diffusion model with the geometry prior from the feed-forward model. The leveling adapter enables generation on the artifact area of the extrapolated novel views caused by underconstrained regions of the 3D representation. Specifically, to learn a more diverse distributed generation, we introduce the palette filtering strategy for training, and a test-time masking refinement to prevent messy boundaries along the fixing regions. More importantly, the enhanced extrapolated novel views from Leveling3D could be used as the inputs for feed-forward 3DGS, leveling up the 3D reconstruction. We achieve SOTA performance on public datasets, including tasks such as novel-view synthesis and depth estimation.

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TMR-VLA:Vision-Language-Action Model for Magnetic Motion Control of Tri-leg Silicone-based Soft Robot

In-vivo environments, magnetically actuated soft robots offer advantages such as wireless operation and precise control, showing promising potential for painless detection and therapeutic procedures. We developed a trileg magnetically driven soft robot (TMR) whose multi-legged design enables more flexible gaits and diverse motion patterns. For the silicone made of reconfigurable soft robots, its navigation ability can be separated into sequential motions, namely squatting, rotation, lifting a leg, walking and so on. Its motion and behavior depend on its bending shapes. To bridge motion type description and specific low-level voltage control, we introduced TMR-VLA, an end-to-end multi-modal system for a trileg magnetic soft robot capable of performing hybrid motion types, which is promising for developing a navigation ability by adapting its shape to language-constrained motion types. The TMR-VLA deploys embodied endoluminal localization ability from EndoVLA, and fuses sequential frames and natural language commands as input. Low-level voltage output is generated based on the current observation state and specific motion type description. The result shows the TMR-VLA can predict how the voltage applied to TMR will change the dynamics of a silicon-made soft robot. The TMR-VLA reached a 74% average success rate.

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Geometry OR Tracker: Universal Geometric Operating Room Tracking

In operating rooms (OR), world-scale multi-view 3D tracking supports downstream applications such as surgeon behavior recognition, where physically meaningful quantities such as distances and motion statistics must be measured in meters. However, real clinical deployments rarely satisfy the geometric prerequisites for stable multi-view fusion and tracking: camera calibration and RGB-D registration are always unreliable, leading to cross-view geometric inconsistency that produces "ghosting" during fusion and degrades 3D trajectories in a shared OR coordinate frame. To address this, we introduce Geometry OR Tracker, a two-stage pipeline that first rectifies imprecise calibration into a scaleconsistent and geometrically consistent camera setup with a single global scale via a Multi-view Metric Geometry Rectification module, and then performs Occlusion-Robust 3D Point Tracking directly in the unified OR world frame. On the MM-OR benchmark, improved geometric consistency translates into tracking gains: our rectification front-end reduces cross-view depth disagreement by more than 30$\times$ compared to raw calibration. Ablation studies further demonstrate the relationship between calibration quality and tracking accuracy, showing that improved geometric consistency yields stronger world-frame tracking.

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EndoDDC: Learning Sparse to Dense Reconstruction for Endoscopic Robotic Navigation via Diffusion Depth Completion

Accurate depth estimation plays a critical role in the navigation of endoscopic surgical robots, forming the foundation for 3D reconstruction and safe instrument guidance. Fine-tuning pretrained models heavily relies on endoscopic surgical datasets with precise depth annotations. While existing self-supervised depth estimation techniques eliminate the need for accurate depth annotations, their performance degrades in environments with weak textures and variable lighting, leading to sparse reconstruction with invalid depth estimation. Depth completion using sparse depth maps can mitigate these issues and improve accuracy. Despite the advances in depth completion techniques in general fields, their application in endoscopy remains limited. To overcome these limitations, we propose EndoDDC, an endoscopy depth completion method that integrates images, sparse depth information with depth gradient features, and optimizes depth maps through a diffusion model, addressing the issues of weak texture and light reflection in endoscopic environments. Extensive experiments on two publicly available endoscopy datasets show that our approach outperforms state-of-the-art models in both depth accuracy and robustness. This demonstrates the potential of our method to reduce visual errors in complex endoscopic environments. Our code will be released at https://github.com/yinheng-lin/EndoDDC.

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GeoLanG: Geometry-Aware Language-Guided Grasping with Unified RGB-D Multimodal Learning

Language-guided grasping has emerged as a promising paradigm for enabling robots to identify and manipulate target objects through natural language instructions, yet it remains highly challenging in cluttered or occluded scenes. Existing methods often rely on multi-stage pipelines that separate object perception and grasping, which leads to limited cross-modal fusion, redundant computation, and poor generalization in cluttered, occluded, or low-texture scenes. To address these limitations, we propose GeoLanG, an end-to-end multi-task framework built upon the CLIP architecture that unifies visual and linguistic inputs into a shared representation space for robust semantic alignment and improved generalization. To enhance target discrimination under occlusion and low-texture conditions, we explore a more effective use of depth information through the Depth-guided Geometric Module (DGGM), which converts depth into explicit geometric priors and injects them into the attention mechanism without additional computational overhead. In addition, we propose Adaptive Dense Channel Integration, which adaptively balances the contributions of multi-layer features to produce more discriminative and generalizable visual representations. Extensive experiments on the OCID-VLG dataset, as well as in both simulation and real-world hardware, demonstrate that GeoLanG enables precise and robust language-guided grasping in complex, cluttered environments, paving the way toward more reliable multimodal robotic manipulation in real-world human-centric settings.

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SurgVidLM: Towards Multi-grained Surgical Video Understanding with Large Language Model

Surgical scene understanding is critical for surgical training and robotic decision-making in robot-assisted surgery. Recent advances in Multimodal Large Language Models (MLLMs) have demonstrated great potential for advancing scene perception in the medical domain, facilitating surgeons to understand surgical scenes and procedures. However, these methods are primarily oriented towards image-based analysis or global video understanding, overlooking the fine-grained video reasoning that is crucial for analyzing specific processes and capturing detailed task execution within a surgical procedure. To bridge this gap, we propose SurgVidLM, the first video language model designed to address both full and fine-grained surgical video comprehension. To train our SurgVidLM, we construct the SVU-31K that is a large-scale dataset with over 31K video-instruction pairs, enabling both holistic understanding and detailed analysis of surgical procedures. Building on this resource, SurgVidLM incorporates a two-stage StageFocus mechanism: the first stage extracts global procedural context, while the second stage performs high-frequency local analysis guided by temporal cues. We also develop the Multi-frequency Fusion Attention to effectively integrate low- and high-frequency visual tokens, ensuring the preservation of critical task-specific details. Experimental results demonstrate that SurgVidLM significantly outperforms state-of-the-art Vid-LLMs of comparable parameter scale in both full and fine-grained video understanding tasks, showcasing its superior capability in capturing the context of complex robot-assisted surgeries. Our code and dataset will be publicly accessible soon.

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Comparative validation of surgical phase recognition, instrument keypoint estimation, and instrument instance segmentation in endoscopy: Results of the PhaKIR 2024 challenge

Reliable recognition and localization of surgical instruments in endoscopic video recordings are foundational for a wide range of applications in computer- and robot-assisted minimally invasive surgery (RAMIS), including surgical training, skill assessment, and autonomous assistance. However, robust performance under real-world conditions remains a significant challenge. Incorporating surgical context - such as the current procedural phase - has emerged as a promising strategy to improve robustness and interpretability. To address these challenges, we organized the Surgical Procedure Phase, Keypoint, and Instrument Recognition (PhaKIR) sub-challenge as part of the Endoscopic Vision (EndoVis) challenge at MICCAI 2024. We introduced a novel, multi-center dataset comprising thirteen full-length laparoscopic cholecystectomy videos collected from three distinct medical institutions, with unified annotations for three interrelated tasks: surgical phase recognition, instrument keypoint estimation, and instrument instance segmentation. Unlike existing datasets, ours enables joint investigation of instrument localization and procedural context within the same data while supporting the integration of temporal information across entire procedures. We report results and findings in accordance with the BIAS guidelines for biomedical image analysis challenges. The PhaKIR sub-challenge advances the field by providing a unique benchmark for developing temporally aware, context-driven methods in RAMIS and offers a high-quality resource to support future research in surgical scene understanding.

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Where It Moves, It Matters: Referring Surgical Instrument Segmentation via Motion

Enabling intuitive, language-driven interaction with surgical scenes is a critical step toward intelligent operating rooms and autonomous surgical robotic assistance. However, the task of referring segmentation, localizing surgical instruments based on natural language descriptions, remains underexplored in surgical videos, with existing approaches struggling to generalize due to reliance on static visual cues and predefined instrument names. In this work, we introduce SurgRef, a novel motion-guided framework that grounds free-form language expressions in instrument motion, capturing how tools move and interact across time, rather than what they look like. This allows models to understand and segment instruments even under occlusion, ambiguity, or unfamiliar terminology. To train and evaluate SurgRef, we present Ref-IMotion, a diverse, multi-institutional video dataset with dense spatiotemporal masks and rich motion-centric expressions. SurgRef achieves state-of-the-art accuracy and generalization across surgical procedures, setting a new benchmark for robust, language-driven surgical video segmentation.

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Does DINOv3 Set a New Medical Vision Standard? Benchmarking 2D and 3D Classification, Segmentation, and Registration

The advent of large-scale vision foundation models, pre-trained on diverse natural images, has marked a paradigm shift in computer vision. However, how the frontier vision foundation models' efficacies transfer to specialised domains such as medical imaging remains an open question. This report investigates whether DINOv3, a state-of-the-art self-supervised vision transformer (ViT) pre-trained on natural images, can directly serve as a powerful, unified encoder for medical vision tasks without domain-specific fine-tuning. To answer this, we benchmark DINOv3 across common medical vision tasks, including 2D and 3D classification, segmentation, and registration on a wide range of medical imaging modalities. We systematically analyse its scalability by varying model sizes and input image resolutions. Our findings reveal that DINOv3 shows impressive performance and establishes a formidable new baseline. Remarkably, it can even outperform medical-specific foundation models like BiomedCLIP and CT-Net on several tasks, despite being trained solely on natural images. However, we identify clear limitations: The model's features degrade in scenarios requiring deep domain specialisation, such as in whole-slide images (WSIs), electron microscopy (EM), and positron emission tomography (PET). Furthermore, we observe that DINOv3 does not consistently follow the scaling law in the medical domain. Its performance does not reliably increase with larger models or finer feature resolutions, showing diverse scaling behaviours across tasks. Overall, our work establishes DINOv3 as a strong baseline, whose powerful visual features can serve as a robust prior for multiple medical tasks. This opens promising future directions, such as leveraging its features to enforce multiview consistency in 3D reconstruction.

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