arXiv subjects

Marvin Fritz

Publications and source records attributed to Marvin Fritz.

36 records · Page 2Linked to original sources

arXiv2024

Stabilization to trajectories of nonisothermal Cahn-Hilliard equations

In this work, it is proven the semiglobal exponential stabilization to time-dependent trajectories of the nonisothermal Cahn-Hilliard equations. In the model, the input controls are given by explicit feedback operators that involve appropriate oblique projections. The actuators are given by a finite number of indicator functions. The results also hold for the isothermal Cahn-Hilliard system. Numerical simulations are shown that illustrate the stabilizing performance of the proposed input feedback operators.

math.OC↗

arXiv2024

On the well-posedness of the Cahn-Hilliard-Biot model and its applications to tumor growth

We study the Cahn-Hilliard-Biot model with respect to its mathematical well-posedness. The system models flow through deformable porous media in which the solid material has two phases with distinct material properties. The two phases of the porous material evolve according to a generalized Ginzburg-Landau energy functional, with additional influence from both viscoelastic and fluid effects. The flow-deformation coupling in the system is governed by Biot's theory. This results in a three-way coupled system that can be viewed as an extension of the Cahn-Larche equations by adding a fluid flowing through the medium. We distinguish the cases between a spatially dependent and a state-dependent Biot-Willis function. In the latter case, we consider a regularized system. In both cases, we use a Galerkin approximation to discretize the system and derive suitable energy estimates. Moreover, we apply compactness methods to pass to the limit in the discretized system. In the case of Vegard's law and homogeneous elasticity, we show that the weak solution depends continuously on the data and is unique. Lastly, we present some numerical simulations to highlight the features of the system as a tumor growth model.

math.AP↗

arXiv2024

Well-posedness, long-time behavior, and discretization of some models of nonlinear acoustics in velocity-enthalpy formulation

We study a class of models for nonlinear acoustics, including the well-known Westervelt and Kuznetsov equations, as well as a model of Rasmussen that can be seen as a thermodynamically consistent modification of the latter. Using linearization, energy estimates, and fixed-point arguments, we establish the existence and uniqueness of solutions that, for sufficiently small data, are global in time and converge exponentially fast to equilibrium. In contrast to previous work, our analysis is based on a velocity-enthalpy formulation of the problem, whose weak form reveals the underlying port-Hamiltonian structure. Moreover, the weak form of the problem is particularly well-suited for a structure-preserving discretization. This is demonstrated in numerical tests, which also highlight typical characteristics of the models under consideration.

math.AP↗

arXiv2024

Structure-preserving approximation of the Cahn-Hilliard-Biot system

In this work, we propose a structure-preserving discretisation for the recently studied Cahn-Hilliard-Biot system using conforming finite elements in space and problem-adapted explicit-implicit Euler time integration. We prove that the scheme preserves the thermodynamic structure, that is, the balance of mass and volumetric fluid content and the energy dissipation balance. The existence of discrete solutions is established under suitable growth conditions. Furthermore, it is shown that the algorithm can be realised as a splitting method, that is, decoupling the Cahn-Hilliard subsystem from the poro-elasticity subsystem, while the first one is nonlinear and the second subsystem is linear. The schemes are illustrated by numerical examples and a convergence test.

math.NA↗

arXiv2023

Analysis and computations of a stochastic Cahn-Hilliard model for tumor growth with chemotaxis and variable mobility

In this work, we present and analyze a system of PDEs, which models tumor growth by considering chemotaxis, active transport, and random effects. The stochasticity of the system is modelled by random initial data and Wiener noises that appear in the tumor and nutrient equations. The volume fraction of the tumor is governed by a stochastic phase-field equation of Cahn-Hilliard type, and the mass density of the nutrients is modelled by a stochastic reaction-diffusion equation. We allow a variable mobility function and non-increasing growth functions, such as logistic and Gompertzian growth. Via approximation and stochastic compactness arguments, we prove the existence of a probabilistic weak solution and, in the case of constant mobilities, the well-posedness of the model in the strong probabilistic sense. Lastly, we propose a numerical approximation based on the Galerkin finite element method in space and the semi-implicit Euler-Maruyama scheme in time. We illustrate the effects of the stochastic forcing in the tumor growth in several numerical simulations.

math.AP↗

arXiv2023

Well-posedness and simulation of weak solutions to the time-fractional Fokker-Planck equation with general forcing

In this paper, we investigate the well-posedness of weak solutions to the time-fractional Fokker-Planck equation. Its dynamics is governed by anomalous diffusion, and we consider the most general case of space-time dependent forces. Consequently, the fractional derivatives appear on the right-hand side of the equation, and they cannot be brought to the left-hand side, which would have been preferable from an analytical perspective. For showing the model's well-posedness, we derive an energy inequality by considering nonstandard and novel testing methods that involve a series of convolutions and integrations. We close the estimate by a Henry-Gronwall-type inequality. Lastly, we propose a numerical algorithm based on a nonuniform L1 scheme and present some simulation results for various forces.

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arXiv2023

Analysis of a dilute polymer model with a time-fractional derivative

We investigate the well-posedness of a coupled Navier-Stokes-Fokker-Planck system with a time-fractional derivative. Such systems arise in the kinetic theory of dilute solutions of polymeric liquids, where the motion of noninteracting polymer chains in a Newtonian solvent is modelled by a stochastic process exhibiting power-law waiting time, in order to capture subdiffusive processes associated with non-Fickian diffusion. We outline the derivation of the model from a subordinated Langevin equation. The elastic properties of the polymer molecules immersed in the solvent are modelled by a finitely extensible nonlinear elastic (FENE) dumbbell model, and the drag term in the Fokker--Planck equation is assumed to be corotational. We prove the global-in-time existence of large-data weak solutions to this time-fractional model of order $α\in (\tfrac12,1)$, and derive an energy inequality satisfied by weak solutions.

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arXiv2023

Tumor evolution models of phase-field type with nonlocal effects and angiogenesis

In this survey article, a variety of systems modeling tumor growth are discussed. In accordance with the hallmarks of cancer, the described models incorporate the primary characteristics of cancer evolution. Specifically, we focus on diffusive interface models and follow the phase-field approach that describes the tumor as a collection of cells. Such systems are based on a multiphase approach that employs constitutive laws and balance laws for individual constituents. In mathematical oncology, numerous biological phenomena are involved, including temporal and spatial nonlocal effects, complex nonlinearities, stochasticity, and mixed-dimensional couplings. Using the models, for instance, we can express angiogenesis and cell-to-matrix adhesion effects. Finally, we offer some methods for numerically approximating the models and show simulations of the tumor's evolution in response to various biological effects.

math.DS↗

arXiv2023

A phase-field model for non-small cell lung cancer under the effects of immunotherapy

Formulating tumor models that predict growth under therapy is vital for improving patient-specific treatment plans. In this context, we present our recent work on simulating non-small-scale cell lung cancer (NSCLC) in a simple, deterministic setting for two different patients receiving an immunotherapeutic treatment. At its core, our model consists of a Cahn-Hilliard-based phase-field model describing the evolution of proliferative and necrotic tumor cells. These are coupled to a simplified nutrient model that drives the growth of the proliferative cells and their decay into necrotic cells. The applied immunotherapy decreases the proliferative cell concentration. Here, we model the immunotherapeutic agent concentration in the entire lung over time by an ordinary differential equation (ODE). Finally, reaction terms provide a coupling between all these equations. By assuming spherical, symmetric tumor growth and constant nutrient inflow, we simplify this full 3D cancer simulation model to a reduced 1D model. We can then resort to patient data gathered from computed tomography (CT) scans over several years to calibrate our model. For the reduced 1D model, we show that our model can qualitatively describe observations during immunotherapy by fitting our model parameters to existing patient data. Our model covers cases in which the immunotherapy is successful and limits the tumor size, as well as cases predicting a sudden relapse, leading to exponential tumor growth. Finally, we move from the reduced model back to the full 3D cancer simulation in the lung tissue. Thereby, we show the predictive benefits a more detailed patient-specific simulation including spatial information could yield in the future.

math.NA↗

arXiv2022

A 1D-0D-3D coupled model for simulating blood flow and transport processes in breast tissue

In this work, we present mixed dimensional models for simulating blood flow and transport processes in breast tissue and the vascular tree supplying it. These processes are considered, to start from the aortic inlet to the capillaries and tissue of the breast. Large variations in biophysical properties and flow conditions exist in this system necessitating the use of different flow models for different geometries and flow regimes. Large variations in biophysical properties and flow conditions exist in this system necessitating the use of different flow models for different geometries and flow regimes. In total, we consider four different model types. First, a system of 1D nonlinear hyperbolic PDEs is considered to simulate blood flow in larger arteries with highly elastic vessel walls. Second, we assign 1D linearized hyperbolic PDEs to model the smaller arteries with stiffer vessel walls. The third model type consists of ODE systems (0D models). It is used to model the arterioles and peripheral circulation. Finally, homogenized 3D porous media models are considered to simulate flow and transport in capillaries and tissue within the breast volume. Sink terms are used to account for the influence of the venous and lymphatic systems. Combining the four model types, we obtain two different 1D-0D-3D coupled models for simulating blood flow and transport processes: The first 1D-0D-3D model covers the whole path from the aorta to the breast, while the second model is a sub-model obtained by restriction to breast vasculature and tissue making possible a significant reduction in computational cost. Several numerical experiments are conducted that demonstrate realistic flow simulations compared to existing data on blood flow in human breast and vascular system.

q-bio.TO↗

arXiv2021

On a subdiffusive tumour growth model with fractional time derivative

In this work, we present and analyse a system of coupled partial differential equations, which models tumour growth under the influence of subdiffusion, mechanical effects, nutrient supply, and chemotherapy. The subdiffusion of the system is modelled by a time fractional derivative in the equation governing the volume fraction of the tumour cells. The mass densities of the nutrients and the chemotherapeutic agents are modelled by reaction diffusion equations. We prove the existence and uniqueness of a weak solution to the model via the Faedo--Galerkin method and the application of appropriate compactness theorems. Lastly, we propose a fully discretised system and illustrate the effects of the fractional derivative and the influence of the fractional parameter in numerical examples.

math.AP↗

arXiv2021

Equivalence between a time-fractional and an integer-order gradient flow: The memory effect reflected in the energy

Time-fractional partial differential equations are nonlocal in time and show an innate memory effect. In this work, we propose an augmented energy functional which includes the history of the solution. Further, we prove the equivalence of a time-fractional gradient flow problem to an integer-order one based on our new energy. This equivalence guarantees the dissipating character of the augmented energy. The state function of the integer-order gradient flow acts on an extended domain similar to the Caffarelli-Silvestre extension for the fractional Laplacian. Additionally, we apply a numerical scheme for solving time-fractional gradient flows, which is based on kernel compressing methods. We illustrate the behavior of the original and augmented energy in the case of the Ginzburg-Landau energy functional.

math.AP↗

arXiv2021

Modeling and simulation of vascular tumors embedded in evolving capillary networks

In this work, we present a coupled 3D-1D model of solid tumor growth within a dynamically changing vascular network to facilitate realistic simulations of angiogenesis. Additionally, the model includes erosion of the extracellular matrix, interstitial flow, and coupled flow in blood vessels and tissue. We employ continuum mixture theory with stochastic Cahn--Hilliard type phase-field models of tumor growth. The interstitial flow is governed by a mesoscale version of Darcy's law. The flow in the blood vessels is controlled by Poiseuille flow, and Starling's law is applied to model the mass transfer in and out of blood vessels. The evolution of the network of blood vessels is orchestrated by the concentration of the tumor angiogenesis factors (TAFs); blood vessels grow towards the increasing TAFs concentrations. This process is not deterministic, allowing random growth of blood vessels and, therefore, due to the coupling of nutrients in tissue and vessels, makes the growth of tumors stochastic. We demonstrate the performance of the model by applying it to a variety of scenarios. Numerical experiments illustrate the flexibility of the model and its ability to generate satellite tumors. Simulations of the effects of angiogenesis on tumor growth are presented as well as sample-independent features of cancer.

q-bio.TO↗

arXiv2021

Time-fractional Cahn-Hilliard equation: Well-posedness, degeneracy, and numerical solutions

In this paper, we derive the time-fractional Cahn-Hilliard equation from continuum mixture theory with a modification of Fick's law of diffusion. This model describes the process of phase separation with nonlocal memory effects. We analyze the existence, uniqueness, and regularity of weak solutions of the time-fractional Cahn-Hilliard equation. In this regard, we consider degenerating mobility functions and free energies of Landau, Flory--Huggins and double-obstacle type. We apply the Faedo-Galerkin method to the system, derive energy estimates, and use compactness theorems to pass to the limit in the discrete form. In order to compensate for the missing chain rule of fractional derivatives, we prove a fractional chain inequality for semiconvex functions. The work concludes with numerical simulations and a sensitivity analysis showing the influence of the fractional power. Here, we consider a convolution quadrature scheme for the time-fractional component, and use a mixed finite element method for the space discretization.

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arXiv2021

Analysis of a new multispecies tumor growth model coupling 3D phase-fields with a 1D vascular network

In this work, we present and analyze a mathematical model for tumor growth incorporating ECM erosion, interstitial flow, and the effect of vascular flow and nutrient transport. The model is of phase-field or diffused-interface type in which multiple phases of cell species and other constituents are separated by smooth evolving interfaces. The model involves a mesoscale version of Darcy's law to capture the flow mechanism in the tissue matrix. Modeling flow and transport processes in the vasculature supplying the healthy and cancerous tissue, one-dimensional (1D) equations are considered. Since the models governing the transport and flow processes are defined together with cell species models on a three-dimensional (3D) domain, we obtain a 3D-1D coupled model. We show some mathematical results on the existence of weak solutions. Furthermore, simulation results are presented illustrating the evolution of tumors and the effects of ECM erosion.

math.AP↗

arXiv2019

On the unsteady Darcy-Forchheimer-Brinkman equation in local and nonlocal tumor growth models

A mathematical analysis of local and nonlocal phase-field models of tumor growth is presented that includes time-dependent Darcy-Forchheimer-Brinkman models of convective velocity fields and models of long-range cell interactions. A complete existence analysis is provided. In addition, a parameter-sensitivity analysis is described that quantifies the sensitivity of key quantities of interest to changes in parameter values. Two sensitivity analyses are examined; one employing statistical variances of model outputs and another employing the notion of active subspaces based on existing observational data. Remarkably, the two approaches yield very similar conclusions on sensitivity for certain quantities of interest. The work concludes with the presentation of numerical approximations of solutions of the governing equations and results of numerical experiments on tumor growth produced using finite element discretizations of the full tumor model for representative cases.

math.AP↗

arXiv2019

Local and nonlocal phase-field models of tumor growth and invasion due to ECM degradation

We present and analyze new multi-species phase-field mathematical models of tumor growth and ECM invasion. The local and nonlocal mathematical models describe the evolution of volume fractions of tumor cells, viable cells (proliferative and hypoxic cells), necrotic cells, and the evolution of MDE and ECM, together with chemotaxis, haptotaxis, apoptosis, nutrient distribution, and cell-to-matrix adhesion. We provide a rigorous proof of the existence of solutions of the coupled system with gradient-based and adhesion-based haptotaxis effects. In addition, we discuss finite element discretizations of the model, and we present the results of numerical experiments designed to show the relative importance and roles of various effects, including cell mobility, proliferation, necrosis, hypoxia, and nutrient concentration on the generation of MDEs and the degradation of the ECM.

math.AP↗

arXiv2018

Well-posedness and numerical treatment of the Blackstock equation in nonlinear acoustics

We study the Blackstock equation which models the propagation of nonlinear sound waves through dissipative fluids. Global well-posedness of the model with homogeneous Dirichlet boundary conditions is shown for small initial data. To this end, we employ a fixed-point technique coupled with well-posedness results for a linearized model and appropriate energy estimates. Furthermore, we obtain exponential decay for the energy of the solution. We present additionally a finite element-based method for solving the Blackstock equation and illustrate the behavior of solutions through several numerical experiments.

math.AP↗