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Maxim Topaz

Publications and source records attributed to Maxim Topaz.

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Biomedical Reference Generation Remains Unreliable across 26 Large Language Models

Background. Large language models are increasingly used to help write biomedical text but may fabricate references to nonexistent work. How often large language models do so is not well characterized. Methods. We prompted 26 language models from eight developers (2023 to 2026) to supply a missing reference for each of 69 biomedical passages across ten domains. References were classified as verifiable (real paper with a resolving identifier), partial matches (real paper without a resolving identifier), fabricated (no matching indexed paper), or declined (the model refused to supply a reference). A reference was considered correct in every evaluated bibliographic field only when it was verifiable and its journal, year, and listed authors matched those of the cited paper. Results. Fabrication ranged from 10.2% (Claude Opus 4.8, which declined 52.1% of prompts) to 98.4% (Ministral 3B, which produced no verifiable reference). Claude Opus 4.6 and Claude Sonnet 4.5 produced similar proportions of verifiable references (77.6% and 76.6%) but named authors correctly in 78.7% and 28.7% of author-evaluable verifiable references, respectively, and were correct in every evaluated field in 54.6% and 19.9% of responses. GPT-5.5 was correct in every field in 48.1%. Across all models, 55.4% of responses were fabricated and 14.9% were correct in every field. Among the five tested models first released in 2026, the corresponding proportions were 35.3% and 31.8%, respectively. Conclusions. Fabrication remained common, and no model was correct in every evaluated bibliographic field in more than 54.6% of responses. Models that identify real papers may still misstate their metadata, so references produced with model assistance require verification before use.

cs.CL

When Vocal Tone and Literal Meaning Diverge: An Acoustic-Semantic Incongruity Study for Large Audio-Language Models

Affective cues across modalities may be incongruous (e.g., sarcasm or mocking praise), potentially leading to misinterpretation when relying on a single modality. Large Audio-Language Models (LALMs) have recently gained popularity and been applied to multimodal emotion recognition, but their ability to disentangle acoustic and semantic cues, especially in incongruent cases, remains underexplored. To address this gap, we introduce CREMA-ASIS, a dataset specifically created to investigate incongruence between acoustic emotion and semantic sentiment cues. It pairs acoustic emotion labels with semantic sentiment polarities. Using this dataset, we evaluate LALM biases within a multitask framework and conduct a layer-wise analysis to identify modality dominance across layers. Our findings reveal that LALMs struggle with semantic-acoustic incongruent cases, rarely predicting incongruity, and that LALMs are predominantly influenced by semantic information. However, supervised fine-tuning significantly improves LALM performance on our CREMA-ASIS test set while preserving transcription accuracy and joint emotion recognition. Results demonstrate potential for enhancing both acoustic and semantic understanding on out-of-domain data.

eess.AS

From Who Said What to Who They Are: Modular Training-free Identity-Aware LLM Refinement of Speaker Diarization

Speaker diarization (SD) remains challenging in real-world scenarios due to dynamic environments and unknown speaker numbers. SD is rarely used alone and is typically paired with automatic speech recognition (ASR). However, existing non-modular SD+ASR frameworks lack flexibility and do not provide true speaker identities. We propose a training-free modular pipeline combining off-the-shelf SD, ASR, and a large language model (LLM) to determine who spoke, what was said, and who they are. Using structured LLM prompting on reconciled SD and ASR outputs, our method leverages semantic continuity in conversational context to refine low-confidence speaker labels and assigns role identities while correcting split speakers. On a real-world patient-clinician dataset, our approach achieves a 29.7% relative error reduction over baseline reconciled SD and ASR. It enhances diarization performance without additional training and delivers a complete pipeline for SD, ASR, and speaker identity detection in practical applications.

eess.AS

Hearing Health in Home Healthcare: Leveraging LLMs for Illness Scoring and ALMs for Vocal Biomarker Extraction

The growing demand for home healthcare calls for tools that can support care delivery. In this study, we explore automatic health assessment from voice using real-world home care visit data, leveraging the diverse patient information it contains. First, we utilize Large Language Models (LLMs) to integrate Subjective, Objective, Assessment, and Plan (SOAP) notes derived from unstructured audio transcripts and structured vital signs into a holistic illness score that reflects a patient's overall health. This compact representation facilitates cross-visit health status comparisons and downstream analysis. Next, we design a multi-stage preprocessing pipeline to extract short speech segments from target speakers in home care recordings for acoustic analysis. We then employ an Audio Language Model (ALM) to produce plain-language descriptions of vocal biomarkers and examine their association with individuals' health status. Our experimental results benchmark both commercial and open-source LLMs in estimating illness scores, demonstrating their alignment with actual clinical outcomes, and revealing that SOAP notes are substantially more informative than vital signs. Building on the illness scores, we provide the first evidence that ALMs can identify health-related acoustic patterns from home care recordings and present them in a human-readable form. Together, these findings highlight the potential of LLMs and ALMs to harness heterogeneous in-home visit data for better patient monitoring and care.

eess.AS

UM_FHS at TREC 2024 PLABA: Exploration of Fine-tuning and AI agent approach for plain language adaptations of biomedical text

This paper describes our submissions to the TREC 2024 PLABA track with the aim to simplify biomedical abstracts for a K8-level audience (13-14 years old students). We tested three approaches using OpenAI's gpt-4o and gpt-4o-mini models: baseline prompt engineering, a two-AI agent approach, and fine-tuning. Adaptations were evaluated using qualitative metrics (5-point Likert scales for simplicity, accuracy, completeness, and brevity) and quantitative readability scores (Flesch-Kincaid grade level, SMOG Index). Results indicated that the two-agent approach and baseline prompt engineering with gpt-4o-mini models show superior qualitative performance, while fine-tuned models excelled in accuracy and completeness but were less simple. The evaluation results demonstrated that prompt engineering with gpt-4o-mini outperforms iterative improvement strategies via two-agent approach as well as fine-tuning with gpt-4o. We intend to expand our investigation of the results and explore advanced evaluations.

cs.CL