arXiv subjects

Md Osman Gani

Publications and source records attributed to Md Osman Gani.

21 records · Page 2Linked to original sources

arXiv2022

Causal Discovery on the Effect of Antipsychotic Drugs on Delirium Patients in the ICU using Large EHR Dataset

Delirium occurs in about 80% cases in the Intensive Care Unit (ICU) and is associated with a longer hospital stay, increased mortality and other related issues. Delirium does not have any biomarker-based diagnosis and is commonly treated with antipsychotic drugs (APD). However, multiple studies have shown controversy over the efficacy or safety of APD in treating delirium. Since randomized controlled trials (RCT) are costly and time-expensive, we aim to approach the research question of the efficacy of APD in the treatment of delirium using retrospective cohort analysis. We plan to use the Causal inference framework to look for the underlying causal structure model, leveraging the availability of large observational data on ICU patients. To explore safety outcomes associated with APD, we aim to build a causal model for delirium in the ICU using large observational data sets connecting various covariates correlated with delirium. We utilized the MIMIC III database, an extensive electronic health records (EHR) dataset with 53,423 distinct hospital admissions. Our null hypothesis is: there is no significant difference in outcomes for delirium patients under different drug-group in the ICU. Through our exploratory, machine learning based and causal analysis, we had findings such as: mean length-of-stay and max length-of-stay is higher for patients in Haloperidol drug group, and haloperidol group has a higher rate of death in a year compared to other two-groups. Our generated causal model explicitly shows the functional relationships between different covariates. For future work, we plan to do time-varying analysis on the dataset.

cs.LG↗

arXiv2021

Multispectral Object Detection with Deep Learning

Object detection in natural scenes can be a challenging task. In many real-life situations, the visible spectrum is not suitable for traditional computer vision tasks. Moving outside the visible spectrum range, such as the thermal spectrum or the near-infrared (NIR) images, is much more beneficial in low visibility conditions, NIR images are very helpful for understanding the object's material quality. In this work, we have taken images with both the Thermal and NIR spectrum for the object detection task. As multi-spectral data with both Thermal and NIR is not available for the detection task, we needed to collect data ourselves. Data collection is a time-consuming process, and we faced many obstacles that we had to overcome. We train the YOLO v3 network from scratch to detect an object from multi-spectral images. Also, to avoid overfitting, we have done data augmentation and tune hyperparameters.

cs.CV↗

arXiv2020

Structural Causal Model with Expert Augmented Knowledge to Estimate the Effect of Oxygen Therapy on Mortality in the ICU

Recent advances in causal inference techniques, more specifically, in the theory of structural causal models, provide the framework for identification of causal effects from observational data in the cases where the causal graph is identifiable, i.e., the data generating mechanism can be recovered from the joint distribution. However, no such studies have been done to demonstrate this concept with a clinical example. We present a complete framework to estimate the causal effect from observational data by augmenting expert knowledge in the model development phase and with a practical clinical application. Our clinical application entails a timely and important research question, i.e., the effect of oxygen therapy intervention in the intensive care unit (ICU); the result of this project is useful in a variety of disease conditions, including severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) patients in the ICU. We used data from the MIMIC III database, a standard database in the machine learning community that contains 58,976 admissions from an ICU in Boston, MA, for estimating the oxygen therapy effect on morality. We also identified the covariate-specific effect to oxygen therapy from the model for more personalized intervention.

cs.LG↗