arXiv subjects

Michele Santacatterina

Publications and source records attributed to Michele Santacatterina.

24 records · Page 2Linked to original sources

arXiv2021

Robust weights that optimally balance confounders for estimating marginal hazard ratios

Covariate balance is crucial in obtaining unbiased estimates of treatment effects in observational studies. Methods based on inverse probability weights have been widely used to estimate treatment effects with observational data. Machine learning techniques have been proposed to estimate propensity scores. These techniques however target accuracy instead of covariate balance. Methods that target covariate balance have been successfully proposed and largely applied to estimate treatment effects on continuous outcomes. However, in many medical and epidemiological applications, the interest lies in estimating treatment effects on time-to-event outcomes. With this type of data, one of the most common estimands of interest is the marginal hazard ratio of the Cox proportional hazard model. In this paper, we start by presenting robust orthogonality weights (ROW), a set of weights obtained by solving a quadratic constrained optimization problem that maximizes precision while constraining covariate balance defined as the sample correlation between confounders and treatment. By doing so, ROW optimally deal with both binary and continuous treatments. We then evaluate the performance of the proposed weights in estimating marginal hazard ratios of binary and continuous treatments with time-to-event outcomes in a simulation study. We finally apply ROW on the evaluation of the effect of hormone therapy on time to coronary heart disease and on the effect of red meat consumption on time to colon cancer among 24,069 postmenopausal women enrolled in the Women's Health Initiative observational study.

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arXiv2019

Kernel Optimal Orthogonality Weighting: A Balancing Approach to Estimating Effects of Continuous Treatments

Many scientific questions require estimating the effects of continuous treatments. Outcome modeling and weighted regression based on the generalized propensity score are the most commonly used methods to evaluate continuous effects. However, these techniques may be sensitive to model misspecification, extreme weights or both. In this paper, we propose Kernel Optimal Orthogonality Weighting (KOOW), a convex optimization-based method, for estimating the effects of continuous treatments. KOOW finds weights that minimize the worst-case penalized functional covariance between the continuous treatment and the confounders. By minimizing this quantity, KOOW successfully provides weights that orthogonalize confounders and the continuous treatment, thus providing optimal covariate balance, while controlling for extreme weights. We valuate its comparative performance in a simulation study. Using data from the Women's Health Initiative observational study, we apply KOOW to evaluate the effect of red meat consumption on blood pressure.

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arXiv2019

Optimal Estimation of Generalized Average Treatment Effects using Kernel Optimal Matching

In causal inference, a variety of causal effect estimands have been studied, including the sample, uncensored, target, conditional, optimal subpopulation, and optimal weighted average treatment effects. Ad-hoc methods have been developed for each estimand based on inverse probability weighting (IPW) and on outcome regression modeling, but these may be sensitive to model misspecification, practical violations of positivity, or both. The contribution of this paper is twofold. First, we formulate the generalized average treatment effect (GATE) to unify these causal estimands as well as their IPW estimates. Second, we develop a method based on Kernel Optimal Matching (KOM) to optimally estimate GATE and to find the GATE most easily estimable by KOM, which we term the Kernel Optimal Weighted Average Treatment Effect. KOM provides uniform control on the conditional mean squared error of a weighted estimator over a class of models while simultaneously controlling for precision. We study its theoretical properties and evaluate its comparative performance in a simulation study. We illustrate the use of KOM for GATE estimation in two case studies: comparing spine surgical interventions and studying the effect of peer support on people living with HIV.

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arXiv2019

CAB: Continuous Adaptive Blending Estimator for Policy Evaluation and Learning

The ability to perform offline A/B-testing and off-policy learning using logged contextual bandit feedback is highly desirable in a broad range of applications, including recommender systems, search engines, ad placement, and personalized health care. Both offline A/B-testing and off-policy learning require a counterfactual estimator that evaluates how some new policy would have performed, if it had been used instead of the logging policy. In this paper, we identify a family of counterfactual estimators which subsumes most such estimators proposed to date. Our analysis of this family identifies a new estimator - called Continuous Adaptive Blending (CAB) - which enjoys many advantageous theoretical and practical properties. In particular, it can be substantially less biased than clipped Inverse Propensity Score (IPS) weighting and the Direct Method, and it can have less variance than Doubly Robust and IPS estimators. In addition, it is sub-differentiable such that it can be used for learning, unlike the SWITCH estimator. Experimental results show that CAB provides excellent evaluation accuracy and outperforms other counterfactual estimators in terms of learning performance.

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arXiv2019

Optimal Balancing of Time-Dependent Confounders for Marginal Structural Models

Marginal structural models (MSMs) estimate the causal effect of a time-varying treatment in the presence of time-dependent confounding via weighted regression. The standard approach of using inverse probability of treatment weighting (IPTW) can lead to high-variance estimates due to extreme weights and be sensitive to model misspecification. Various methods have been proposed to partially address this, including truncation and stabilized-IPTW to temper extreme weights and covariate balancing propensity score (CBPS) to address treatment model misspecification. In this paper, we present Kernel Optimal Weighting (KOW), a convex-optimization-based approach that finds weights for fitting the MSM that optimally balance time-dependent confounders while simultaneously controlling for precision, directly addressing the above limitations. KOW directly minimizes the error in estimation due to time-dependent confounding via a new decomposition as a functional. We further extend KOW to control for informative censoring. We evaluate the performance of KOW in a simulation study, comparing it with IPTW, stabilized-IPTW, and CBPS. We demonstrate the use of KOW in studying the effect of treatment initiation on time-to-death among people living with HIV and the effect of negative advertising on elections in the United States.

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arXiv2019

More robust estimation of sample average treatment effects using Kernel Optimal Matching in an observational study of spine surgical interventions

Inverse probability of treatment weighting (IPTW), which has been used to estimate sample average treatment effects (SATE) using observational data, tenuously relies on the positivity assumption and the correct specification of the treatment assignment model, both of which are problematic assumptions in many observational studies. Various methods have been proposed to overcome these challenges, including truncation, covariate-balancing propensity scores, and stable balancing weights. Motivated by an observational study in spine surgery, in which positivity is violated and the true treatment assignment model is unknown, we present the use of optimal balancing by Kernel Optimal Matching (KOM) to estimate SATE. By uniformly controlling the conditional mean squared error of a weighted estimator over a class of models, KOM simultaneously mitigates issues of possible misspecification of the treatment assignment model and is able to handle practical violations of the positivity assumption, as shown in our simulation study. Using data from a clinical registry, we apply KOM to compare two spine surgical interventions and demonstrate how the result matches the conclusions of clinical trials that IPTW estimates spuriously refute.

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