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Sébastien Courvoisier

Publications and source records attributed to Sébastien Courvoisier.

4 recordsLinked to original sources

MoSAIK: Motion Search with Artificial Intelligence in K-space

Object: Motion artefacts remain a major limitation of routine two-dimensional T2-weighted turbo spin-echo (TSE) brain MRI, reducing diagnostic confidence and often necessitating repeated acquisitions. MoSAIK (Motion Search with AI in K-space) retrospectively estimates in-plane rigid-body motion directly from standard multi-coil TSE k-space. Without a motion-free reference, external navigators, or additional acquisitions, MoSAIK infers motion from k-space self-consistency violations and incorporates predicted parameters into model-based, motion-aware reconstruction rather than synthesizing corrected images. Materials and Methods: Selected complex coil data were represented as log-magnitude and phase channels. A decoupled convolutional embedding and Transformer encoder estimated phase-encoding-line-indexed rotation and two-dimensional translations. Training used motion-free clinical acquisitions with simulated motion; four held-out subjects were evaluated. Component-wise errors assessed estimation; SSIM and PSNR in silico and entropy focus criterion (EFC) in vivo assessed reconstruction. Results: Motion estimation errors were low for both rotation (MSE $<$ 0.2 deg$^2$) and translation (MSE $<$ 0.2 pixels$^2$), with Pearson correlations of approximately 0.96 and 0.94, respectively. In every in-vivo acquisition, more than 75% of slices showed information gain relative to uncorrected reconstructions. MoSAIK reduced visible artefacts while preserving anatomical detail. Discussion: Transformer-based k-space motion-trajectory estimation enables fast retrospective correction of standard clinical TSE brain MRI.

cs.AI↗

WALINET: A water and lipid identification convolutional Neural Network for nuisance signal removal in 1H MR Spectroscopic Imaging

Purpose. Proton Magnetic Resonance Spectroscopic Imaging (1H-MRSI) provides non-invasive spectral-spatial mapping of metabolism. However, long-standing problems in whole-brain 1H-MRSI are spectral overlap of metabolite peaks with large lipid signal from scalp, and overwhelming water signal that distorts spectra. Fast and effective methods are needed for high-resolution 1H-MRSI to accurately remove lipid and water signals while preserving the metabolite signal. The potential of supervised neural networks for this task remains unexplored, despite their success for other MRSI processing. Methods. We introduce a deep-learning method based on a modified Y-NET network for water and lipid removal in whole-brain 1H-MRSI. The WALINET (WAter and LIpid neural NETwork) was compared to conventional methods such as the state-of-the-art lipid L2 regularization and Hankel-Lanczos singular value decomposition (HLSVD) water suppression. Methods were evaluated on simulated and in-vivo whole-brain MRSI using NMRSE, SNR, CRLB, and FWHM metrics. Results. WALINET is significantly faster and needs 8s for high-resolution whole-brain MRSI, compared to 42 minutes for conventional HLSVD+L2. Quantitative analysis shows WALINET has better performance than HLSVD+L2: 1) more lipid removal with 41% lower NRMSE, 2) better metabolite signal preservation with 71% lower NRMSE in simulated data, 155% higher SNR and 50% lower CRLB in in-vivo data. Metabolic maps obtained by WALINET in healthy subjects and patients show better gray/white-matter contrast with more visible structural details. Conclusions. WALINET has superior performance for nuisance signal removal and metabolite quantification on whole-brain 1H-MRSI compared to conventional state-of-the-art techniques. This represents a new application of deep-learning for MRSI processing, with potential for automated high-throughput workflow.

eess.IV↗

SISMIK for brain MRI: Deep-learning-based motion estimation and model-based motion correction in k-space

MRI, a widespread non-invasive medical imaging modality, is highly sensitive to patient motion. Despite many attempts over the years, motion correction remains a difficult problem and there is no general method applicable to all situations. We propose a retrospective method for motion estimation and correction to tackle the problem of in-plane rigid-body motion, apt for classical 2D Spin-Echo scans of the brain, which are regularly used in clinical practice. Due to the sequential acquisition of k-space, motion artifacts are well localized. The method leverages the power of deep neural networks to estimate motion parameters in k-space and uses a model-based approach to restore degraded images to avoid ''hallucinations''. Notable advantages are its ability to estimate motion occurring in high spatial frequencies without the need of a motion-free reference. The proposed method operates on the whole k-space dynamic range and is moderately affected by the lower SNR of higher harmonics. As a proof of concept, we provide models trained using supervised learning on 600k motion simulations based on motion-free scans of 43 different subjects. Generalization performance was tested with simulations as well as in-vivo. Qualitative and quantitative evaluations are presented for motion parameter estimations and image reconstruction. Experimental results show that our approach is able to obtain good generalization performance on simulated data and in-vivo acquisitions. We provide a Python implementation at https://gitlab.unige.ch/Oscar.Dabrowski/sismik_mri/.

eess.IV↗

Simultaneous Multi-Harmonic Imaging of Nanoparticles in Tissues for Increased Selectivity

We investigate the use of Bismuth Ferrite (BFO) nanoparticles for tumor tissue labelling in combination with infrared multi-photon excitation at 1250 nm. We report the efficient and simultaneous generation of second and third harmonic by the nanoparticles. On this basis, we set up a novel imaging protocol based on the co-localization of the two harmonic signals and demonstrate its benefits in terms of increased selectivity against endogenous background sources in tissue samples. Finally, we discuss the use of BFO nanoparticles as mapping reference structures for correlative light-electron microscopy.

physics.optics↗