arXiv subjects

S. Westerhoff

Publications and source records attributed to S. Westerhoff.

At least 19 recordsLinked to original sources

arXiv2026

Clustering based magnetic assays for SARS-CoV-2 detection with scFv-functionalized magnetic nanoparticles

Magnetic nanoparticles (MNP) can be used in magnetic immunoassays (MIA) by functionalizing them with antibodies. In homogeneous assays that follow a "mix-and-measure" approach, it is then sufficient to add the sample in question and evaluate the response of the MNPs using a magnetic measurement method. Magnetic Particle Spectroscopy (MPS) is a fast and sensitive method for this purpose, capable of determining the binding state by measuring changes in Brownian relaxation. For further analysis, alternating current susceptometry (ACS) is considered, although it is significantly more time-consuming and therefore no option for applications interested in point of care detection. In this study, we aim to further improve the approach of MIA evaluated by MPS. To this end, we use self-synthesized scFv fragments instead of whole IgG antibodies during functionalization in order to keep the size of the BNF-Dextran MNP with 80 nm nominal diameter as small as possible, which allows for greater relative size changes upon binding to an analyte. Virus-like particles (VLP) and the N protein of SARS-CoV-2, which were also produced in-house, are used as analytes. Due to multiple binding sites, these form cluster structures, which, in the case of VLP, were investigated in greater depth ACS to assess their field dependence. In addition, the sensitivity of the assays was analyzed as a function of MNP concentration, and the detection limit for both analytes was estimated. We found that, using scFv-functionalized MNPs, we were able to detect low concentrations of just 490 fM of SARS-CoV-2 VLP and 1.7 nM of the N protein. However, the slightly above-proportional increase in sensitivity as the MNP concentration decreases does not automatically imply a better detection limit.

physics.med-ph↗

arXiv2018

First HAWC Observations of the Sun Constrain Steady TeV Gamma-Ray Emission

Steady gamma-ray emission up to at least 200 GeV has been detected from the solar disk in the Fermi-LAT data, with the brightest, hardest emission occurring during solar minimum. The likely cause is hadronic cosmic rays undergoing collisions in the Sun's atmosphere after being redirected from ingoing to outgoing in magnetic fields, though the exact mechanism is not understood. An important new test of the gamma-ray production mechanism will follow from observations at higher energies. Only the High Altitude Water Cherenkov (HAWC) Observatory has the required sensitivity to effectively probe the Sun in the TeV range. Using three years of HAWC data from November 2014 to December 2017, just prior to the solar minimum, we search for 1--100 TeV gamma rays from the solar disk. No evidence of a signal is observed, and we set strong upper limits on the flux at a few $10^{-12}$ TeV$^{-1}$ cm$^{-2}$ s$^{-1}$ at 1 TeV. Our limit, which is the most constraining result on TeV gamma rays from the Sun, is $\sim10\%$ of the theoretical maximum flux (based on a model where all incoming cosmic rays produce outgoing photons), which in turn is comparable to the Fermi-LAT data near 100 GeV. The prospects for a first TeV detection of the Sun by HAWC are especially high during solar minimum, which began in early 2018.

astro-ph.HE↗

arXiv2018

Constraints on Spin-Dependent Dark Matter Scattering with Long-Lived Mediators from TeV Observations of the Sun with HAWC

We analyze the Sun as a source for the indirect detection of dark matter through a search for gamma rays from the solar disk. Capture of dark matter by elastic interactions with the solar nuclei followed by annihilation to long-lived mediators can produce a detectable gamma-ray flux. We search three years of data from the High Altitude Water Cherenkov Observatory and find no statistically significant detection of TeV gamma-ray emission from the Sun. Using this, we constrain the spin-dependent elastic scattering cross section of dark matter with protons for dark matter masses above 1 TeV, assuming an unstable mediator with a favorable lifetime. The results complement constraints obtained from Fermi-LAT observations of the Sun and together cover WIMP masses between 4 GeV and $10^6$ GeV. The cross section constraints for mediator decays to gamma rays can be as strong as $\sim10^{-45}$ cm$^{-2}$, which is more than four orders of magnitude stronger than current direct-detection experiments for 1 TeV dark matter mass. The cross-section constraints at higher masses are even better, nearly 7 orders of magnitude better than the current direct-detection constraints for 100 TeV dark matter mass. This demonstration of sensitivity encourages detailed development of theoretical models in light of these powerful new constraints.

hep-ph↗

arXiv2018

Observation of Anisotropy of TeV Cosmic Rays with Two Years of HAWC

After two years of operation, the High-Altitude Water Cherenkov (HAWC) Observatory has analyzed the TeV cosmic-ray sky over an energy range between $2.0$ and $72.8$ TeV. The HAWC detector is a ground-based air-shower array located at high altitude in the state of Puebla, Mexico. Using 300 light-tight water tanks, it collects the Cherenkov light from the particles of extensive air showers from primary gamma rays and cosmic rays. This detection method allows for uninterrupted observation of the entire overhead sky (2~sr instantaneous, 8.5~sr integrated) in the energy range from a few TeV to hundreds of TeV. Like other detectors in the northern and southern hemisphere, HAWC observes an energy-dependent anisotropy in the arrival direction distribution of cosmic rays. The observed cosmic-ray anisotropy is dominated by a dipole moment with phase $\alpha\approx40^{\circ}$ and amplitude that slowly rises in relative intensity from $8\times10^{-4}$ at 2 TeV to $14\times10^{-4}$ around 30.3 TeV, above which the dipole decreases in strength. A significant large-scale ($>60^{\circ}$ in angular extent) signal is also observed in the quadrupole and octupole moments, and significant small-scale features are also present, with locations and shapes consistent with previous observations. Compared to previous measurements in this energy range, the HAWC cosmic-ray sky maps improve on the energy resolution and fit precision of the anisotropy. These data can be used in an effort to better constrain local cosmic-ray accelerators and the intervening magnetic fields.

astro-ph.HE↗

arXiv2018

Search for Dark Matter Gamma-ray Emission from the Andromeda Galaxy with the High-Altitude Water Cherenkov Observatory

The Andromeda Galaxy (M31) is a nearby ($\sim$780 kpc) galaxy similar to our own Milky Way. Observational evidence suggests that it resides in a large halo of dark matter (DM), making it a good target for DM searches. We present a search for gamma rays from M31 using 1017 days of data from the High Altitude Water Cherenkov (HAWC) Observatory. With its wide field of view and constant monitoring, HAWC is well-suited to search for DM in extended targets like M31. No DM annihilation or decay signal was detected for DM masses from 1 to 100 TeV in the $b\bar{b}$, $t\bar{t}$, $\tau^{+}\tau^{-}$, $\mu^{+}\mu^{-}$, and $W^{+}W^{-}$ channels. Therefore we present limits on those processes. Our limits nicely complement the existing body of DM limits from other targets and instruments. Specifically the DM decay limits from our benchmark model are the most constraining for DM masses from 25 TeV to 100 TeV in the $b\bar{b}, t\bar{t}$ and $\mu^{+}\mu{-}$ channels. In addition to DM-specific limits, we also calculate general gamma-ray flux limits for M31 in 5 energy bins from 1 TeV to 100 TeV.

astro-ph.HE↗

arXiv2018

Constraining the $\bar{p}/p$ Ratio in TeV Cosmic Rays with Observations of the Moon Shadow by HAWC

An indirect measurement of the antiproton flux in cosmic rays is possible as the particles undergo deflection by the geomagnetic field. This effect can be measured by studying the deficit in the flux, or shadow, created by the Moon as it absorbs cosmic rays that are headed towards the Earth. The shadow is displaced from the actual position of the Moon due to geomagnetic deflection, which is a function of the energy and charge of the cosmic rays. The displacement provides a natural tool for momentum/charge discrimination that can be used to study the composition of cosmic rays. Using 33 months of data comprising more than 80 billion cosmic rays measured by the High Altitude Water Cherenkov (HAWC) observatory, we have analyzed the Moon shadow to search for TeV antiprotons in cosmic rays. We present our first upper limits on the $\bar{p}/p$ fraction, which in the absence of any direct measurements, provide the tightest available constraints of $\sim1\%$ on the antiproton fraction for energies between 1 and 10 TeV.

astro-ph.HE↗

arXiv2017

A Search for Dark Matter in the Galactic Halo with HAWC

The High Altitude Water Cherenkov (HAWC) gamma-ray observatory is a wide field-of-view observatory sensitive to 500 GeV - 100 TeV gamma rays and cosmic rays. With its observations over 2/3 of the sky every day, the HAWC observatory is sensitive to a wide variety of astrophysical sources, including possible gamma rays from dark matter. Dark matter annihilation and decay in the Milky Way Galaxy should produce gamma-ray signals across many degrees on the sky. The HAWC instantaneous field-of-view of 2 sr enables observations of extended regions on the sky, such as those from dark matter in the Galactic halo. Here we show limits on the dark matter annihilation cross-section and decay lifetime from HAWC observations of the Galactic halo with 15 months of data. These are some of the most robust limits on TeV and PeV dark matter, largely insensitive to the dark matter morphology. These limits begin to constrain models in which PeV IceCube neutrinos are explained by dark matter which primarily decays into hadrons.

astro-ph.HE↗

arXiv2017

All-particle cosmic ray energy spectrum measured by the HAWC experiment from 10 to 500 TeV

We report on the measurement of the all-particle cosmic ray energy spectrum with the High Altitude Water Cherenkov (HAWC) Observatory in the energy range 10 to 500 TeV. HAWC is a ground based air-shower array deployed on the slopes of Volcan Sierra Negra in the state of Puebla, Mexico, and is sensitive to gamma rays and cosmic rays at TeV energies. The data used in this work were taken from 234 days between June 2016 to February 2017. The primary cosmic-ray energy is determined with a maximum likelihood approach using the particle density as a function of distance to the shower core. Introducing quality cuts to isolate events with shower cores landing on the array, the reconstructed energy distribution is unfolded iteratively. The measured all-particle spectrum is consistent with a broken power law with an index of $-2.49\pm0.01$ prior to a break at $(45.7\pm0.1$) TeV, followed by an index of $-2.71\pm0.01$. The spectrum also respresents a single measurement that spans the energy range between direct detection and ground based experiments. As a verification of the detector response, the energy scale and angular resolution are validated by observation of the cosmic ray Moon shadow's dependence on energy.

astro-ph.HE↗

arXiv2017

Data Acquisition Architecture and Online Processing System for the HAWC gamma-ray observatory

The High Altitude Water Cherenkov observatory (HAWC) is an air shower array devised for TeV gamma-ray astronomy. HAWC is located at an altitude of 4100 m a.s.l. in Sierra Negra, Mexico. HAWC consists of 300 Water Cherenkov Detectors, each instrumented with 4 photomultiplier tubes (PMTs). HAWC re-uses the Front-End Boards from the Milagro experiment to receive the PMT signals. These boards are used in combination with Time to Digital Converters (TDCs) to record the time and the amount of light in each PMT hit (light flash). A set of VME TDC modules (128 channels each) is operated in a continuous (dead time free) mode. The TDCs are read out via the VME bus by Single-Board Computers (SBCs), which in turn are connected to a gigabit Ethernet network. The complete system produces ~ 500 MB/s of raw data. A high-throughput data processing system has been designed and built to enable real-time data analysis. The system relies on off-the-shelf hardware components, an open-source software technology for data transfers (ZeroMQ) and a custom software framework for data analysis (AERIE). Multiple trigger and reconstruction algorithms can be combined and run on blocks of data in a parallel fashion, producing a set of output data streams which can be analyzed in real time with minimal latency (< 5 s). This paper provides an overview of the hardware set-up and an in-depth description of the software design, covering both the TDC data acquisition system and the real-time data processing system. The performance of these systems is also discussed.

astro-ph.IM↗

arXiv2017

Search for very-high-energy emission from Gamma-ray Bursts using the first 18 months of data from the HAWC Gamma-ray Observatory

The High Altitude Water Cherenkov (HAWC) Gamma-ray Observatory is an extensive air shower detector operating in central Mexico, which has recently completed its first two years of full operations. If for a burst like GRB 130427A at a redshift of 0.34 and a high-energy component following a power law with index -1.66, the high-energy component is extended to higher energies with no cut-off other than from extragalactic background light attenuation, HAWC would observe gamma rays with a peak energy of $\sim$300 GeV. This paper reports the results of HAWC observations of 64 gamma-ray bursts (GRBs) detected by $\mathit{Swift}$ and $\mathit{Fermi}$, including three GRBs that were also detected by the Large Area Telescope ($\mathit{Fermi}$-LAT). An ON/OFF analysis method is employed, searching on the time scale given by the observed light curve at keV-MeV energies and also on extended time scales. For all GRBs and time scales, no statistically significant excess of counts is found and upper limits on the number of gamma rays and the gamma-ray flux are calculated. GRB 170206A, the third brightest short GRB detected by the Gamma-ray Burst Monitor on board the $\mathit{Fermi}$ satellite ($\mathit{Fermi}$-GBM) and also detected by the LAT, occurred very close to zenith. The LAT measurements can neither exclude the presence of a synchrotron self-Compton (SSC) component nor constrain its spectrum. Instead, the HAWC upper limits constrain the expected cut-off in an additional high-energy component to be less than $100~\rm{GeV}$ for reasonable assumptions about the energetics and redshift of the burst.

astro-ph.HE↗

arXiv2017

Observation of the Crab Nebula with the HAWC Gamma-Ray Observatory

The Crab Nebula is the brightest TeV gamma-ray source in the sky and has been used for the past 25 years as a reference source in TeV astronomy, for calibration and verification of new TeV instruments. The High Altitude Water Cherenkov Observatory (HAWC), completed in early 2015, has been used to observe the Crab Nebula at high significance across nearly the full spectrum of energies to which HAWC is sensitive. HAWC is unique for its wide field-of-view, nearly 2 sr at any instant, and its high-energy reach, up to 100 TeV. HAWC's sensitivity improves with the gamma-ray energy. Above $\sim$1 TeV the sensitivity is driven by the best background rejection and angular resolution ever achieved for a wide-field ground array. We present a time-integrated analysis of the Crab using 507 live days of HAWC data from 2014 November to 2016 June. The spectrum of the Crab is fit to a function of the form $\phi(E) = \phi_0 (E/E_{0})^{-\alpha -\beta\cdot{\rm{ln}}(E/E_{0})}$. The data is well-fit with values of $\alpha=2.63\pm0.03$, $\beta=0.15\pm0.03$, and log$_{10}(\phi_0~{\rm{cm}^2}~{\rm{s}}~{\rm{TeV}})=-12.60\pm0.02$ when $E_{0}$ is fixed at 7 TeV and the fit applies between 1 and 37 TeV. Study of the systematic errors in this HAWC measurement is discussed and estimated to be $\pm$50\% in the photon flux between 1 and 37 TeV. Confirmation of the Crab flux serves to establish the HAWC instrument's sensitivity for surveys of the sky. The HAWC survey will exceed sensitivity of current-generation observatories and open a new view of 2/3 of the sky above 10 TeV.

astro-ph.HE↗

arXiv2015

Search for TeV Gamma-Ray Emission from Point-like Sources in the Inner Galactic Plane with a Partial Configuration of the HAWC Observatory

A survey of the inner Galaxy region of Galactic longitude l in [+15, +50] degree and latitude b in [-4,+4] degree is performed using one-third of the High Altitude Water Cherenkov (HAWC) Observatory operated during its construction phase. To address the ambiguities arising from unresolved sources in the data, we use a maximum likelihood technique to identify point source candidates. Ten sources and candidate sources are identified in this analysis. Eight of these are associated with known TeV sources but not all have differential fluxes compatible with previous measurements. Three sources are detected with significances $>5\,\sigma$ after accounting for statistical trials, and are associated with known TeV sources.

astro-ph.HE↗

arXiv2015

Observation of Anisotropy in the Arrival Direction Distribution of TeV Cosmic Rays with HAWC

The High-Altitude Water Cherenkov (HAWC) Observatory, located 4100 m above sea level near Sierra Negra (19$^\circ$ N) in Mexico, is sensitive to gamma rays and cosmic rays at TeV energies. The arrival direction distribution of cosmic rays at these energies shows significant anisotropy on several angular scales, with a relative intensity ranging between 10$^{-3}$ and 10$^{-4}$. We present the results of a study of cosmic-ray anisotropy based on more than 86 billion cosmic-ray air showers recorded with HAWC since June 2013. The HAWC cosmic-ray sky map, which has a median energy of 2 TeV, exhibits several regions of significantly enhanced cosmic-ray flux. We present the energy dependence of the anisotropy and the cosmic-ray spectrum in the regions of significant excess.

astro-ph.HE↗

arXiv2014

Search for gamma-rays from the unusually bright GRB 130427A with the HAWC Gamma-ray Observatory

The first limits on the prompt emission from the long gamma-ray burst (GRB) 130427A in the $>100\nobreakspace\rm{GeV}$ energy band are reported. GRB 130427A was the most powerful burst ever detected with a redshift $z\lesssim0.5$ and featured the longest lasting emission above $100\nobreakspace\rm{MeV}$. The energy spectrum extends at least up to $95\nobreakspace\rm{GeV}$, clearly in the range observable by the High Altitude Water Cherenkov (HAWC) Gamma-ray Observatory, a new extensive air shower detector currently under construction in central Mexico. The burst occurred under unfavourable observation conditions, low in the sky and when HAWC was running 10% of the final detector. Based on the observed light curve at MeV-GeV energies, eight different time periods have been searched for prompt and delayed emission from this GRB. In all cases, no statistically significant excess of counts has been found and upper limits have been placed. It is shown that a similar GRB close to zenith would be easily detected by the full HAWC detector, which will be completed soon. The detection rate of the full HAWC detector may be as high as one to two GRBs per year. A detection could provide important information regarding the high energy processes at work and the observation of a possible cut-off beyond the $\mathit{Fermi}$-LAT energy range could be the signature of gamma-ray absorption, either in the GRB or along the line of sight due to the extragalactic background light.

astro-ph.HE↗

arXiv2014

Observation of Small-scale Anisotropy in the Arrival Direction Distribution of TeV Cosmic Rays with HAWC

The High-Altitude Water Cherenkov (HAWC) Observatory is sensitive to gamma rays and charged cosmic rays at TeV energies. The detector is still under construction, but data acquisition with the partially deployed detector started in 2013. An analysis of the cosmic-ray arrival direction distribution based on $4.9\times 10^{10}$ events recorded between June 2013 and February 2014 shows anisotropy at the $10^{-4}$ level on angular scales of about $10^\circ$. The HAWC cosmic-ray sky map exhibits three regions of significantly enhanced cosmic-ray flux; two of these regions were first reported by the Milagro experiment. A third region coincides with an excess recently reported by the ARGO-YBJ experiment. An angular power spectrum analysis of the sky shows that all terms up to $\ell=15$ contribute significantly to the excesses.

astro-ph.HE↗

arXiv2014

The Sensitivity of HAWC to High-Mass Dark Matter Annihilations

The High Altitude Water Cherenkov (HAWC) observatory is a wide field-of-view detector sensitive to gamma rays of 100 GeV to a few hundred TeV. Located in central Mexico at 19 degrees North latitude and 4100 m above sea level, HAWC will observe gamma rays and cosmic rays with an array of water Cherenkov detectors. The full HAWC array is scheduled to be operational in Spring 2015. In this paper, we study the HAWC sensitivity to the gamma-ray signatures of high-mass (multi- TeV) dark matter annihilation. The HAWC observatory will be sensitive to diverse searches for dark matter annihilation, including annihilation from extended dark matter sources, the diffuse gamma-ray emission from dark matter annihilation, and gamma-ray emission from non-luminous dark matter subhalos. Here we consider the HAWC sensitivity to a subset of these sources, including dwarf galaxies, the M31 galaxy, the Virgo cluster, and the Galactic center. We simulate the HAWC response to gamma rays from these sources in several well-motivated dark matter annihilation channels. If no gamma-ray excess is observed, we show the limits HAWC can place on the dark matter cross-section from these sources. In particular, in the case of dark matter annihilation into gauge bosons, HAWC will be able to detect a narrow range of dark matter masses to cross-sections below thermal. HAWC should also be sensitive to non-thermal cross-sections for masses up to nearly 1000 TeV. The constraints placed by HAWC on the dark matter cross-section from known sources should be competitive with current limits in the mass range where HAWC has similar sensitivity. HAWC can additionally explore higher dark matter masses than are currently constrained.

astro-ph.HE↗

arXiv2013

The HAWC Gamma-Ray Observatory: Sensitivity to Steady and Transient Sources of Gamma Rays

The High-Altitude Water Cherenkov (HAWC) Gamma-Ray Observatory is designed to record air showers produced by cosmic rays and gamma rays between 100 GeV and 100 TeV. Because of its large field of view and high livetime, HAWC is well-suited to measure gamma rays from extended sources, diffuse emission, and transient sources. We describe the sensitivity of HAWC to emission from the extended Cygnus region as well as other types of galactic diffuse emission; searches for flares from gamma-ray bursts and active galactic nuclei; and the first measurement of the Crab Nebula with HAWC-30.

astro-ph.HE↗

arXiv2013

The HAWC Gamma-Ray Observatory: Observations of Cosmic Rays

We describe measurements of GeV and TeV cosmic rays with the High-Altitude Water Cherenkov Gamma-Ray Observatory, or HAWC. The measurements include the observation of the shadow of the moon; the observation of small-scale and large-scale angular clustering of the TeV cosmic rays; the prospects for measurement of transient solar events with HAWC; and the observation of Forbush decreases with the HAWC engineering array and HAWC-30.

astro-ph.HE↗