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arXiv2026

Blocking of bistable front propagation: Application to Wolbachia population replacement

In order to control epidemics of mosquito-borne diseases such as dengue, for which there is still no vaccine available, several strategies aim to directly target the mosquito population. One technique involves introducing a symbiotic bacterium called Wolbachia into the population, which blocks the transmission of pathogens. A mathematical model of the introduction of this bacterium and the replacement of the mosquito population with a population carrying this bacterium has been developed, proving that in a homogeneous environment, there is spatial propagation of the replacement. The objective of this paper is to study the blocking of this propagation in cases where the environment is not homogeneous. In particular, we are considering scenarios where the environmental carrying capacity varies significantly across different regions of the spatial domain. To achieve this objective, we first reduce the original 2x2 reaction-diffusion system to a single closed equation, providing a simplified framework for studying the dynamics of Wolbachia propagation. We then investigate the blocking of the propagation in the population replacement process, focusing on the effects of spatial variations in the environmental carrying capacity. Numerical simulations have been performed to validate the theoretical results.

math.AP↗

arXiv2023

Modeling compartmentalization within intracellular signaling pathway

We present a new modeling approach for G protein coupled receptors signaling systems, that take into account the compartmentalization of receptors and their effectors, both at plasma membrane and in dynamic intra-cellular vesicles called endosomes. The first building block of the model is about compartment dynamics. It takes into account creation of de-novo endosomes, i.e. endocytosis, recycling of endosomes back to plasma membrane, degradation through transfer into lysosomes as well as endosomes fusion through coagulation dynamics. The second building block is biochemical reactions into each compartments and the transfer of molecules between the dynamical compartments. In this work, we prove sufficient conditions to obtain exponentially ergodicity for the size distribution of intracellular compartments. We futher design a finite volume scheme to simulate our model and show two application cases for receptor trafficking and spatially biased second effector signaling.

math.AP↗