arXiv subjects

Shaista Hussain

Publications and source records attributed to Shaista Hussain.

4 recordsLinked to original sources

arXiv2026

Detecting Glaucoma Across Multi-ethnic Myopic and Non-Myopic Populations Using an Uncertainty-Aware Vision Transformer: A Multicentre Model Development and Validation Study

Background: Artificial intelligence (AI)-based glaucoma detection from colour fundus photographs (CFP) offers scalable screening, but performance may decline on external datasets because of differences in ground-truth definitions, populations, and coexisting conditions such as high myopia (HM). We developed and validated a Vision Transformer-based deep learning (DL) model for glaucoma detection across multi-ethnic cohorts with and without HM. Methods: A ViT-B/16 model with predictive uncertainty estimation was developed using 56,483 CFPs (57.1% with myopia; 14.4% with HM). Glaucoma labels were standardised using clinical, imaging, and perimetry data. The model was validated on 16 independent datasets across three continents, including four datasets with explicit HM labels. Findings: Internal AUROC was 98.7% (95% CI 98.2-99.1%), with sensitivity 94.5% and specificity 97.3%. Across 16 external datasets from eight countries, AUROCs ranged from 86.4% to 99.6%. In HM eyes, internal AUROC was 97.8% (95% CI 96.1-99.2%), with sensitivity 94.8% and specificity 93.7%. External HM AUROCs were 86.5% in the Beijing Eye Study and 93.3%, 91.8%, and 85.5% in hospital-based datasets from Taiwan, Thailand, and South Korea. In an exploratory HM clinical evaluation, the model had higher CFP-only diagnostic accuracy than ophthalmologists and trained graders (92.0% vs 70.0%; p=0.008) and performed comparably to glaucoma specialists using full clinical information. Interpretation: The model showed robust glaucoma detection across myopic and non-myopic multi-ethnic populations and may support AI-assisted screening in settings with high HM prevalence.

cs.CV↗

arXiv2015

Learning Spike time codes through Morphological Learning with Binary Synapses

In this paper, a neuron with nonlinear dendrites (NNLD) and binary synapses that is able to learn temporal features of spike input patterns is considered. Since binary synapses are considered, learning happens through formation and elimination of connections between the inputs and the dendritic branches to modify the structure or "morphology" of the NNLD. A morphological learning algorithm inspired by the 'Tempotron', i.e., a recently proposed temporal learning algorithm-is presented in this work. Unlike 'Tempotron', the proposed learning rule uses a technique to automatically adapt the NNLD threshold during training. Experimental results indicate that our NNLD with 1-bit synapses can obtain similar accuracy as a traditional Tempotron with 4-bit synapses in classifying single spike random latency and pair-wise synchrony patterns. Hence, the proposed method is better suited for robust hardware implementation in the presence of statistical variations. We also present results of applying this rule to real life spike classification problems from the field of tactile sensing.

cs.NE↗

arXiv2014

Hardware-Amenable Structural Learning for Spike-based Pattern Classification using a Simple Model of Active Dendrites

This paper presents a spike-based model which employs neurons with functionally distinct dendritic compartments for classifying high dimensional binary patterns. The synaptic inputs arriving on each dendritic subunit are nonlinearly processed before being linearly integrated at the soma, giving the neuron a capacity to perform a large number of input-output mappings. The model utilizes sparse synaptic connectivity; where each synapse takes a binary value. The optimal connection pattern of a neuron is learned by using a simple hardware-friendly, margin enhancing learning algorithm inspired by the mechanism of structural plasticity in biological neurons. The learning algorithm groups correlated synaptic inputs on the same dendritic branch. Since the learning results in modified connection patterns, it can be incorporated into current event-based neuromorphic systems with little overhead. This work also presents a branch-specific spike-based version of this structural plasticity rule. The proposed model is evaluated on benchmark binary classification problems and its performance is compared against that achieved using Support Vector Machine (SVM) and Extreme Learning Machine (ELM) techniques. Our proposed method attains comparable performance while utilizing 10 to 50% less computational resources than the other reported techniques.

cs.NE↗

arXiv2014

Delay Learning Architectures for Memory and Classification

We present a neuromorphic spiking neural network, the DELTRON, that can remember and store patterns by changing the delays of every connection as opposed to modifying the weights. The advantage of this architecture over traditional weight based ones is simpler hardware implementation without multipliers or digital-analog converters (DACs) as well as being suited to time-based computing. The name is derived due to similarity in the learning rule with an earlier architecture called Tempotron. The DELTRON can remember more patterns than other delay-based networks by modifying a few delays to remember the most 'salient' or synchronous part of every spike pattern. We present simulations of memory capacity and classification ability of the DELTRON for different random spatio-temporal spike patterns. The memory capacity for noisy spike patterns and missing spikes are also shown. Finally, we present SPICE simulation results of the core circuits involved in a reconfigurable mixed signal implementation of this architecture.

cs.NE↗