Simos Koutsoftidis | Search arXiv

arXiv2026

A Portable Multichannel Kilohertz Current Stimulator for Selective Peripheral Transcutaneous Stimulation

We present SineStim, a portable, 12-channel current stimulator for transcutaneous spinal cord stimulation and peripheral electrical stimulation at kilohertz frequencies. Each channel delivers independent, current-controlled sinusoidal waveforms with amplitudes from 0 to 50 mA (0.1 mA resolution) and frequencies from 0 to 50 kHz (0.1 Hz resolution), with burst modulation modes supported. A custom output stage with a high compliance voltage of $\pm$ 120 V was designed and developed, with galvanically isolated channels and independently programmable stimulation parameters for each channel. The stimulator performance was tested on both passive loads and human subjects. Benchtop characterisation on resistive and resistive-capacitive loads demonstrated a total harmonic distortion between 1 - 8 % across typical operating conditions. Multichannel functionality was demonstrated in two-channel human forearm stimulation experiments. Burst-modulated waveforms with differing channel amplitudes modulated inter-finger force ratios, and channels with small frequency offsets elicited temporal interference force patterns at the beat frequency. Smoothly enveloped bursts of kilohertz sinusoidal waveforms produced negligible stimulation artifacts at steady state in concurrent surface electromyography (sEMG) recordings at motor threshold, in contrast to conventional biphasic square wave stimulation. SineStim delivers precise, isolated, multichannel kilohertz stimulation through a portable device, with performance demonstrated on both benchtop loads and human participants. By combining multichannel spatial control with minimal-artifact sEMG compatibility, SineStim enables future precision non-invasive neural stimulation paradigms based on multichannel optimisation and real-time closed-loop control capabilities not available via existing single-channel stimulators.

eess.SP↗

arXiv2026

A Mapping Sheath with Thermally Drawn Multi-Electrode Basket for Cardiac Electrophysiological Recording and Ablation Catheter Delivery

Cardiac arrhythmias, particularly atrial fibrillation, represent a major cardiovascular health burden and underscore the need for efficient and integrated strategies for electrical mapping and targeted therapy. Cardiac electrophysiology procedures depend on accurate identification of arrhythmogenic substrates followed by timely catheter ablation, but conventional diagnostic and therapeutic devices remain separate, often requiring repeated catheter exchanges and multiple access routes. Here, we report an adaptable strategy for functionalizing hollow-core sheaths with EP mapping capabilities, integrating multielectrode recording and ablation catheter delivery within a single compact platform. The device leverages thermal drawing to enable complex geometric fabrication, miniaturization, rapid prototyping, and scalable manufacturing of ultrathin electrode splines arranged circumferentially at the distal end to form an adjustable basket. The mapping sheath exhibited mechanical and electrophysiological properties suitable for intracardiac navigation and electrogram recording in bench-top evaluations, an in vitro left atrial phantom study, and ex vivo Langendorff-perfused porcine heart testing. In vivo porcine studies further demonstrated translational feasibility through vascular introduction, fluoroscopic visualization, intracardiac deployment, tissue contact, electrogram acquisition, and reconstruction of voltage and activation maps. These results support the development of intracardiac platforms with an adapted manufacturing approach, potentially guiding advances in agile cardiac mapping and ablation.

physics.med-ph↗