arXiv subjects
Publications and source records attributed to Tao Tan.
Synthesizing high fidelity contrast enhanced MRI is clinically valuable for safer and more efficient breast cancer screening, yet remains challenging due to complex lesion textures and heterogeneous enhancement patterns.
Emotional understanding and generation are often treated as separate tasks, yet they are inherently complementary and can mutually enhance each other. In this paper, we propose the UniEmo, a unified framework that seamlessly integrates these two tasks. The key challenge lies in the abstract nature of emotions, necessitating the extraction of visual representations beneficial for both tasks. To address this, we propose a hierarchical emotional understanding chain with learnable expert queries that progressively extracts multi-scale emotional features, thereby serving as a foundational step for unification. Simultaneously, we fuse these expert queries and emotional representations to guide the diffusion model in generating emotion-evoking images. To enhance the diversity and fidelity of the generated emotional images, we further introduce the emotional correlation coefficient and emotional condition loss into the fusion process. This step facilitates fusion and alignment for emotional generation guided by the understanding. In turn, we demonstrate that joint training allows the generation component to provide implicit feedback to the understanding part. Furthermore, we propose a novel data filtering algorithm to select high-quality and diverse emotional images generated by the well-trained model, which explicitly feedback into the understanding part. Together, these generation-driven dual feedback processes enhance the model's understanding capacity. Extensive experiments show that UniEmo significantly outperforms state-of-the-art methods in both emotional understanding and generation tasks. The code for the proposed method is available at https://github.com/JiuTian-VL/UniEmo.
Clinical decision-making is a feedback system where risk estimates influence treatment, which in turn changes disease trajectories, and both shape clinicians' measurement practices. Static prediction often fails clinically: models trained on observational care logs conflate disease biology with clinician behavior, particularly under treatment confounder feedback and irregular or informative observation. This Review focuses on intervention-aware disease trajectory modeling in clinical AI--methods estimating patient-specific longitudinal disease evolution and assessing trajectory changes under alternative treatments. We organize the field around six linked components: three decision tasks (factual forecasting, counterfactual estimation, policy evaluation) and three data-generating mechanisms (disease evolution, treatment assignment, observation process) that determine identifiability. We present the first unified framework bridging forecasting, counterfactual trajectories, and policy evaluation across discrete/continuous time, explicitly addressing treatment assignment, time-varying confounding, and observation bias. We synthesize key method families (multistate/joint models, temporal point-process, deep sequence architectures, longitudinal causal inference), map them to relevant components, and align evaluation with claim strength via overlap diagnostics, uncertainty quantification, off-policy robustness, and target-trial validation. This synthesis advances benchmark prediction to decision-grade clinical evidence, enabling treatment-sensitive individualized futures, pre-deployment policy stress-testing, and safer closed-loop learning health systems that adapt/abstain when evidence is insufficient.
While Reinforcement Learning with Verifiable Rewards (RLVR) has proven effective for closed-ended tasks, extending it to open-ended social language games via self-play reveals a critical issue: evolution impasse. Due to the vast strategy space, language agents frequently converge to homogenized behaviors, leading to deterministic match outcomes that eliminate the gradient signals necessary for policy evolution. To tackle this issue, we propose Dual-scale Evolutionary Policy Training (DEPT) for social language games. DEPT introduces a time-scaled evolutionary perception mechanism that detects impasse by quantifying dual-scale value baseline divergence alongside match entropy. Upon perceiving the collapse, it then activates asymmetric advantage reshaping to dynamically modulate the optimization landscape for intervention. Thus, our method effectively restores gradient signals and enforces sustained strategic exploration. Extensive experiments on multiple social language games demonstrate that DEPT outperforms strong baselines, avoiding policy degeneration and driving the continuous evolution of social language agents.
Efficient and explainable breast cancer (BC) risk prediction is critical for large-scale population-based screening. Breast MRI provides functional information for personalized risk assessment. Yet effective modeling remains challenging as fully 3D CNNs capture volumetric context at high computational cost, whereas lightweight 2D CNNs fail to model inter-slice continuity. Importantly, breast MRI modeling for shor- and long-term BC risk stratification remains underexplored. In this study, we propose LoGo-MR, a 2.5D local-global structural modeling framework for five-year BC risk prediction. Aligned with clinical interpretation, our framework first employs neighbor-slice encoding to capture subtle local cues linked to short-term risk. It then integrates transformer-enhanced multiple-instance learning (MIL) to model distributed global patterns related to long-term risk and provide interpretable slice importance. We further apply this framework across axial, sagittal, and coronal planes as LoGo3-MR to capture complementary volumetric information. This multi-plane formulation enables voxel-level risk saliency mapping, which may assist radiologists in localizing risk-relevant regions during breast MRI interpretation. Evaluated on a large breast MRI screening cohort (~7.5K), our method outperforms 2D/3D baselines and existing SOTA MIL methods, achieving AUCs of 0.77-0.69 for 1- to 5-year prediction and improving C-index by ~6% over 3D CNNs. LoGo3-MR further improves overall performance with interpretable localization across three planes, and validation across seven backbones shows consistent gains. These results highlight the clinical potential of efficient MRI-based BC risk stratification for large-scale screening. Code will be released publicly.
Multimodal image fusion enables precise lesion localization and characterization for accurate diagnosis, thereby strengthening clinical decision-making and driving its growing prominence in medical imaging research. A powerful multimodal image fusion model relies on high-quality, clinically representative multimodal training data and a rigorously engineered model architecture. Therefore, the development of such professional radiomics models represents a collaborative achievement grounded in standardized acquisition, clinical-specific expertise, and algorithmic design proficiency, which necessitates protection of associated intellectual property rights. However, current multimodal image fusion models generate fused outputs without built-in mechanisms to safeguard intellectual property rights, inadvertently exposing proprietary model knowledge and sensitive training data through inference leakage. For example, malicious users can exploit fusion outputs and model distillation or other inference-based reverse engineering techniques to approximate the fusion performance of proprietary models. To address this issue, we propose AMIF, the first Authorizable Medical Image Fusion model with built-in authentication, which integrates authorization access control into the image fusion objective. For unauthorized usage, AMIF embeds explicit and visible copyright identifiers into fusion results. In contrast, high-quality fusion results are accessible upon successful key-based authentication.
The rapid deployment of distributed energy resources (DERs) is one of the essential efforts to mitigate global climate change. However, a vast number of small-scale DERs are difficult to manage individually, motivating the introduction of virtual power plants (VPPs). A VPP operator coordinates a group of DERs by setting suitable prices, and aggregates them for interaction with the power grid. In this context, optimal pricing plays a critical role in VPP operation. This paper proposes a robust optimal operation model for VPPs that considers uncertainty in the price elasticity of demand. Specifically, the demand elasticity is found to be influenced by the pricing decision, giving rise to decision-dependent uncertainty (DDU). An improved column-and-constraint (C&CG) algorithm, together with tailored transformation and reformulation techniques, is developed to solve the robust model with DDU efficiently. Case studies based on actual electricity consumption data of London households demonstrate the effectiveness of the proposed model and algorithm.
The effectiveness of convolutional neural networks in medical image segmentation relies on large-scale, high-quality annotations, which are costly and time-consuming to obtain. Even expert-labeled datasets inevitably contain noise arising from subjectivity and coarse delineations, which disrupt feature learning and adversely impact model performance. To address these challenges, this study propose a Geometric-Structural Dual-Guided Network (GSD-Net), which integrates geometric and structural cues to improve robustness against noisy annotations. It incorporates a Geometric Distance-Aware module that dynamically adjusts pixel-level weights using geometric features, thereby strengthening supervision in reliable regions while suppressing noise. A Structure-Guided Label Refinement module further refines labels with structural priors, and a Knowledge Transfer module enriches supervision and improves sensitivity to local details. To comprehensively assess its effectiveness, we evaluated GSD-Net on six publicly available datasets: four containing three types of simulated label noise, and two with multi-expert annotations that reflect real-world subjectivity and labeling inconsistencies. Experimental results demonstrate that GSD-Net achieves state-of-the-art performance under noisy annotations, achieving improvements of 1.58% on Kvasir, 22.76% on Shenzhen, 8.87% on BU-SUC, and 1.77% on BraTS2020 under SR simulated noise. The codes of this study are available at https://github.com/ortonwang/GSD-Net.
Recent vision-language-action (VLA) models have significantly advanced robotic manipulation by unifying perception, reasoning, and control. To achieve such integration, recent studies adopt a predictive paradigm that models future visual states or world knowledge to guide action generation. However, these models emphasize forecasting outcomes rather than reasoning about the underlying process of change, which is essential for determining how to act. To address this, we propose $Δ$VLA, a prior-guided framework that models world-knowledge variations relative to an explicit current-world knowledge prior for action generation, rather than regressing absolute future world states. Specifically, 1) to construct the current world knowledge prior, we propose the Prior-Guided WorldKnowledge Extractor (PWKE). It extracts manipulable regions, spatial relations, and semantic cues from the visual input, guided by auxiliary heads and prior pseudo labels, thus reducing redundancy. 2) Building upon this, to represent how world knowledge evolves under actions, we introduce the Latent World Variation Quantization (LWVQ). It learns a discrete latent space via a VQ-VAE objective to encode world knowledge variations, shifting prediction from full modalities to compact latent. 3)Moreover, to mitigate interference during variation modeling, we design the Conditional Variation Attention (CV-Atten), whichpromotes disentangled learning and preserves the independence of knowledge representations. Extensive experiments on both simulated benchmarks and real-world robotic tasks demonstrate $Δ$VLA achieves state-of-the-art performance while improving efficiency. Code and real-world execution videos are available at https://github.com/JiuTian-VL/DeltaVLA.
Remote photoplethysmography (rPPG) measurement enables non-contact physiological monitoring but suffers from accuracy degradation under head motion and illumination changes. Existing deep learning methods are mostly heuristic and lack theoretical grounding, limiting robustness and interpretability. In this work, we propose a physics-informed rPPG paradigm derived from the Navier-Stokes equations of hemodynamics, showing that the pulse signal follows a second-order dynamical system whose discrete solution naturally leads to a causal convolution, justifying the use of a Temporal Convolutional Network (TCN). Based on this principle, we design the PHASE-Net, a lightweight model with three key components: 1) Zero-FLOPs Axial Swapper module to swap or transpose a few spatial channels to mix distant facial regions, boosting cross-region feature interaction without changing temporal order; 2) Adaptive Spatial Filter to learn a soft spatial mask per frame to highlight signal-rich areas and suppress noise for cleaner feature maps; and 3) Gated TCN, a causal dilated TCN with gating that models long-range temporal dynamics for accurate pulse recovery. Extensive experiments demonstrate that PHASE-Net achieves state-of-the-art performance and strong efficiency, offering a theoretically grounded and deployment-ready rPPG solution. The source code is available at https://github.com/Alex036225/PhaseNet.
Remote photoplethysmography (rPPG) enables non-contact physiological measurement but remains highly susceptible to illumination changes, motion artifacts, and limited temporal modeling. Large Language Models (LLMs) excel at capturing long-range dependencies, offering a potential solution but struggle with the continuous, noise-sensitive nature of rPPG signals due to their text-centric design. To bridge this gap, we introduce the PhysLLM, a collaborative optimization framework that synergizes LLMs with domain-specific rPPG components. Specifically, the Text Prototype Guidance (TPG) strategy is proposed to establish cross-modal alignment by projecting hemodynamic features into LLM-interpretable semantic space, effectively bridging the representational gap between physiological signals and linguistic tokens. Besides, a novel Dual-Domain Stationary (DDS) Algorithm is proposed for resolving signal instability through adaptive time-frequency domain feature re-weighting. Finally, rPPG task-specific cues systematically inject physiological priors through physiological statistics, environmental contextual answering, and task description, leveraging cross-modal learning to integrate both visual and textual information, enabling dynamic adaptation to challenging scenarios like variable illumination and subject movements. Evaluation on four benchmark datasets, PhysLLM achieves state-of-the-art accuracy and robustness, demonstrating superior generalization across lighting variations and motion scenarios. The source code is available at https://github.com/Alex036225/PhysLLM.
This paper presents a large language model (LLM) agent named AgentCAT, which extracts and analyzes catalytic reaction data from chemical engineering papers, %and supports natural language based interactive analysis of the extracted data. AgentCAT serves as an alternative to overcome the long-standing data bottleneck in chemical engineering field, and its natural language based interactive data analysis functionality is friendly to the community. AgentCAT also presents a formal abstraction and challenge analysis of the catalytic reaction data extraction task in an artificial intelligence-friendly manner. This abstraction would help the artificial intelligence community understand this problem and in turn would attract more attention to address it. Technically, the complex catalytic process leads to complicated dependency structure in catalytic reaction data with respect to elementary reaction steps, molecular behaviors, measurement evidence, etc. This dependency structure makes it challenging to guarantee the correctness and completeness of data extraction, as well as representing them for analysis. AgentCAT addresses this challenge and it makes four folds of technical contributions: (1) a schema-governed extraction pipeline with progressive schema evolution, enabling robust data extraction from chemical engineering papers; (2) a dependency-aware reaction-network knowledge graph that links catalysts/active sites, synthesis-derived descriptors, mechanistic claims with evidence, and macroscopic outcomes, preserving process coupling and traceability; (3) a general querying module that supports natural-language exploration and visualization over the constructed graph for cross-paper analysis; (4) an evaluation on $\sim$800 peer-reviewed chemical engineering publications demonstrating the effectiveness of AgentCAT.
The reinforcement fine-tuning area is undergoing an explosion papers largely on optimizing design choices. Though performance gains are often claimed, inconsistent conclusions also arise from time to time, making the progress illusive. Reflecting on this illusion, we still lack principled answers to two fundamental questions: 1) what is the role of each design choice? 2) which ones are critical? This paper aims to shed light on them. The underlying challenge is that design choices are entangled together, making their contribution to learning and generalization difficult to attribute. To address this challenge, we first construct a minimalist baseline for disentangling factors: one rollout per query in each round, the outcome reward serving as the training signal without any advantage trick, and a batch size of thirty-two. This baseline connects to batched contextual bandit learning, which facilitates experimental analysis. Centering around this baseline, we design an experiment pipeline, examining the marginal gains of factors like advantage, number of rollouts, etc. Experiments on three base models and two datasets, not only reveal new understanding on the role of various design choices on learning and generalization dynamics, but also identify critical ones that deserve more effort.
High-fidelity 3D meshes can be tokenized into one-dimension (1D) sequences and directly modeled using autoregressive approaches for faces and vertices. However, existing methods suffer from insufficient resource utilization, resulting in slow inference and the ability to handle only small-scale sequences, which severely constrains the expressible structural details. We introduce the Latent Autoregressive Network (LANE), which incorporates compact autoregressive dependencies in the generation process, achieving a $6\times$ improvement in maximum generatable sequence length compared to existing methods. To further accelerate inference, we propose the Adaptive Computation Graph Reconfiguration (AdaGraph) strategy, which effectively overcomes the efficiency bottleneck of traditional serial inference through spatiotemporal decoupling in the generation process. Experimental validation demonstrates that LANE achieves superior performance across generation speed, structural detail, and geometric consistency, providing an effective solution for high-quality 3D mesh generation.
A large number of heuristics have been proposed to optimize the reinforcement fine-tuning of LLMs. However, inconsistent claims are made from time to time, making this area elusive. Reflecting on this situation, two fundamental questions still lack a clear understanding: 1) what is the role of each optimizing choice? 2) which ones are the bottlenecks? This paper aims to shed light on them, and it faces the challenge of several entangled confounding factors in the fine-tuning process. To tackle this challenge, we propose a bottom-up experiment pipeline. The bottom layer is composed of a minimalist configuration: one training data, one rollout per round and the reward directly serve as the learning signal without advantage function design. This minimalist configuration connects to multi-armed bandit learning with extremely large discrete action space, which offers theories to corroborate the experiment findings. The up procedure of the experiment pipeline expanding the minimalist configuration layer by layer, examining the role of each design choice. Experimental results on three LLMs and two reasoning datasets not only reveal new understanding of the design choice but also yield essential insights to shape the area.
The segmentation of mass lesions in digital breast tomosynthesis (DBT) images is very significant for the early screening of breast cancer. However, the high-density breast tissue often leads to high concealment of the mass lesions, which makes manual annotation difficult and time-consuming. As a result, there is a lack of annotated data for model training. Diffusion models are commonly used for data augmentation, but the existing methods face two challenges. First, due to the high concealment of lesions, it is difficult for the model to learn the features of the lesion area. This leads to the low generation quality of the lesion areas, thus limiting the quality of the generated images. Second, existing methods can only generate images and cannot generate corresponding annotations, which restricts the usability of the generated images in supervised training. In this work, we propose a paired image generation method. The method does not require external conditions and can achieve the generation of paired images by training an extra diffusion guider for the conditional diffusion model. During the experimental phase, we generated paired DBT slices and mass lesion masks. Then, we incorporated them into the supervised training process of the mass lesion segmentation task. The experimental results show that our method can improve the generation quality without external conditions. Moreover, it contributes to alleviating the shortage of annotated data, thus enhancing the performance of downstream tasks. The source code is available at https://github.com/zhanghx1320/PIG.
IMPORTANCE: Modern ultrasound systems are universal diagnostic tools capable of imaging the entire body. However, current AI solutions remain fragmented into single-task tools. This critical gap between hardware versatility and software specificity limits workflow integration and clinical utility. OBJECTIVE: To evaluate the diagnostic accuracy, versatility, and efficiency of single general-purpose deep learning models for multi-organ classification and segmentation. DESIGN: The Universal UltraSound Image Challenge 2025 (UUSIC25) involved developing algorithms on 11,644 images aggregated from 12 sources (9 public, 3 private). Evaluation used an independent, multi-center private test set of 2,479 images, including data from a center completely unseen during training to assess generalization. OUTCOMES: Diagnostic performance (Dice Similarity Coefficient [DSC]; Area Under the Receiver Operating Characteristic Curve [AUC]) and computational efficiency (inference time, GPU memory). RESULTS: Of 15 valid algorithms, the top model (SMART) achieved a macro-averaged DSC of 0.854 across 5 segmentation tasks and AUC of 0.766 for binary classification. Models demonstrated high capability in anatomical segmentation (e.g., fetal head DSC: 0.942) but variability in complex diagnostic tasks subject to domain shift. Specifically, in breast cancer molecular subtyping, the top model's performance dropped from an AUC of 0.571 (internal) to 0.508 (unseen external center), highlighting the challenge of generalization. CONCLUSIONS: General-purpose AI models can achieve high accuracy and efficiency across multiple tasks using a single architecture. However, significant performance degradation on unseen data suggests domain generalization is critical for future clinical deployment.
Existing multi-object image generation methods face difficulties in achieving precise alignment between localized image generation regions and their corresponding semantics based on language descriptions, frequently resulting in inconsistent object quantities and attribute aliasing. To mitigate this limitation, mainstream approaches typically rely on external control signals to explicitly constrain the spatial layout, local semantic and visual attributes of images. However, this strong dependency makes the input format rigid, rendering it incompatible with the heterogeneous resource conditions of users and diverse constraint requirements. To address these challenges, we propose MoGen, a user-friendly multi-object image generation method. First, we design a Regional Semantic Anchor (RSA) module that precisely anchors phrase units in language descriptions to their corresponding image regions during the generation process, enabling text-to-image generation that follows quantity specifications for multiple objects. Building upon this foundation, we further introduce an Adaptive Multi-modal Guidance (AMG) module, which adaptively parses and integrates various combinations of multi-source control signals to formulate corresponding structured intent. This intent subsequently guides selective constraints on scene layouts and object attributes, achieving dynamic fine-grained control. Experimental results demonstrate that MoGen significantly outperforms existing methods in generation quality, quantity consistency, and fine-grained control, while exhibiting superior accessibility and control flexibility. Code is available at: https://github.com/Tear-kitty/MoGen/tree/master.