arXiv subjects

Victoria Booth

Publications and source records attributed to Victoria Booth.

6 recordsLinked to original sources

arXiv2026

A Data-Driven Measure of REM Sleep Propensity for Human and Rodent Sleep

Mammalian sleep is characterized by multiple alternations between episodes of rapid-eye-movement sleep (REMS) and non-REM sleep (NREMS). While the mechanisms governing the timing of these ultradian NREMS-REMS cycles remain poorly understood, the phenomenon of REMS pressure, namely a drive for REMS that builds up between REMS episodes, is thought to be a contributing factor. Prior analyses of NREMS-REMS cycles in mice has suggested that time in NREMS is a primary contributor to REMS pressure. Building on that finding, we previously introduced a REMS propensity measure defined as the probability to enter REMS before the accumulation of an additional amount of NREMS. Analyzing mouse ultradian cycle data, we showed that REMS propensity at REMS onset was positively correlated with REMS bout duration and with the probability of the occurrence of a REMS bout followed by a short inter-REMS interval, called a sequential REMS cycle. In this paper, we extend our analyses of REMS propensity to human and rat ultradian NREMS-REMS cycle data. We show that, as in mice, human and rat sleep contain both short NREMS-REMS sequential cycles and longer single NREMS-REMS cycles, though there are some differences in the relative distributions of cycle durations. Although rodents exhibit polyphasic sleep in contrast with the consolidated sleep of humans, the calculated REMS propensity measures in all three species show similar profiles as functions of time spent in NREMS: specifically, REMS propensity increases with time spent in NREMS until it reaches a peak value, and then it decays with additional time in NREMS. Positive correlations of REMS propensity at REMS onset with REMS bout duration were present in both human and rat data as in mouse data, suggesting that time spent in NREMS also influences REMS duration in these species.

q-bio.QM↗

arXiv2025

External light schedules can induce nighttime sleep disruptions in a Homeostat-Circadian-Light Model for sleep in young children

Sleep disturbances, particularly nighttime waking, are highly prevalent in young children and can significantly disrupt not only the child's well-being but also family functioning. Behavioral and environmental strategies, including the regulation of light exposure, are typically recommended treatments for nighttime waking. Using the Homeostatic-Circadian-Light (HCL) mathematical model for sleep timing based on the interaction of the circadian rhythm, the homeostatic sleep drive and external light, we analyze how external light schedules can influence the occurrence of nighttime waking in young children. We fit the model to data for sleep homeostasis and sleep behavior in 2 - 3.5 year olds and identified subsets of parameter ranges that fit the data but indicated a susceptibility to nighttime waking. This suggests that as children develop they may exhibit more or less propensity to awaken during the night. Notably, parameter sets exhibiting earlier sleep timing were more susceptible to nighttime waking. For a model parameter set susceptible to, but not exhibiting, nighttime waking, we analyze how external light schedules affect sleep patterns. We find that low daytime light levels can induce nighttime sleep disruptions and extended bright-light exposure also promotes nighttime waking. Further results suggest that consistent daily routines are essential; irregular schedules, particularly during weekends, markedly worsen the consolidation of nighttime sleep. Specifically, weekend delays in morning lights-on and evening lights-off times result in nighttime sleep disruptions and can influence sleep timing during the week. These results highlight how external light, daily rhythms, and parenting routines interact to shape childrens' sleep health, providing a useful framework for improving sleep management practices.

q-bio.NC↗

arXiv2025

Accuracy versus Predominance: Reassessing the validity of the quasi-steady-state approximation

The application of the standard quasi-steady-state approximation to the Michaelis--Menten reaction mechanism is a textbook example of biochemical model reduction, derived using singular perturbation theory. However, determining the specific biochemical conditions that dictate the validity of the standard quasi-steady-state approximation remains a challenging endeavor. Emerging research suggests that the accuracy of the standard quasi-steady-state approximation improves as the ratio of the initial enzyme concentration, $e_0$, to the Michaelis constant, $K_M$, decreases. In this work, we examine this ratio and its implications for the accuracy and validity of the standard quasi-steady-state approximation as compared to other quasi-steady-state reductions in its proximity. Using standard tools from the analysis of ordinary differential equations, we show that while $e_0/K_M$ provides an indication of the standard quasi-steady-state approximation's asymptotic accuracy, the standard quasi-steady-state approximation's predominance relies on a small ratio of $e_0$ to the Van Slyke-Cullen constant, $K$. Here, we define the predominance of a quasi-steady-state reduction when it offers the highest approximation accuracy among other well-known reductions with overlapping validity conditions. We conclude that the magnitude of $e_0/K$ offers the most accurate measure of the validity of the standard quasi-steady-state approximation.

physics.chem-ph↗

arXiv2021

Bifurcations of sleep patterns due to homeostatic and circadian variation in a sleep-wake flip-flop model

Differential equation-based physiological models of sleep-wake networks describe sleep-wake regulation by simulating the activity of wake- and sleep-promoting neuronal populations and the modulation of these populations by homeostatic and circadian ($\sim24$ h) drives. Here, we consider a sleep-wake flip-flop network model consisting of mutually inhibitory interactions between wake- and sleep-promoting neuronal populations. Motivated by changes in sleep behavior during early childhood as babies transition from napping to non-napping behavior, we vary homeostatic and circadian modulation and analyze effects on resulting sleep-wake patterns. To identify the types and sequences of bifurcations leading to changes in stable sleep-wake patterns in this piecewise-smooth model, we employ multiple mathematical methods, including fast-slow decomposition and numerical computation of circle maps. We find that the average daily number of sleeps exhibits a period adding sequence as the homeostatic time constants are reduced, and that the temporal circadian profile influences the number of observed solutions in the sequence. These solutions emerge through sequences of saddle-node and border collision bifurcations, where the particular sequence depends on parameter values. When the temporal circadian profile is steep, as is observed with long day lengths, some sleep patterns are lost and bistability of other patterns may occur. We analyze a limiting case of the temporal circadian waveform, a circadian hard switch model, to understand this loss of solutions. Generally, our holistic analysis approach provides an alternative analysis method for model systems that defy conventional numerical bifurcation analysis techniques.

math.DS↗

arXiv2019

Seasonality and Light Phase-Resetting in the Mammalian Circadian Rhythm

We study the impact of light on the mammalian circadian system using the theory of phase response curves. Using a recently developed ansatz we derive a low-dimensional macroscopic model for the core circadian clock in mammals. Significantly, the variables and parameters in our model have physiological interpretations and may be compared with experimental results. We focus on the effect of four key factors which help shape the mammalian phase response to light: heterogeneity in the population of oscillators, the structure of the typical light phase response curve, the fraction of oscillators which receive direct light input and changes in the coupling strengths associated with seasonal day-lengths. We find these factors can explain several experimental results and provide insight into the processing of light information in the mammalian circadian system. In particular, we find that the sensitivity of the circadian system to light may be modulated by changes in the relative coupling forces between the light sensing and non-sensing populations. Finally, we show how seasonal day-length, after-effects to light entrainment and seasonal variations in light sensitivity in the mammalian circadian clock are interrelated.

q-bio.NC↗

arXiv2017

Macroscopic Models for Networks of Coupled Biological Oscillators

The study of synchronization in populations of coupled biological oscillators is fundamental to many areas of biology to include neuroscience, cardiac dynamics and circadian rhythms. Studying these systems may involve tracking the concentration of hundreds of variables in thousands of individual cells resulting in an extremely high-dimensional description of the system. However, for many of these systems the behaviors of interest occur on a collective or macroscopic scale. We define a new macroscopic reduction for networks of coupled oscillators motivated by an elegant structure we find in experimental measurements of circadian gene expression and several mathematical models for coupled biological oscillators. We characterize the emergence of this structure through a simple argument and demonstrate its applicability to stochastic and heterogeneous systems of coupled oscillators. Finally, we perform the macroscopic reduction for the heterogeneous stochastic Kuramoto equation and compare the low-dimensional macroscopic model with numerical results from the high-dimensional microscopic model.

q-bio.QM↗