arXiv subjects

Weixu Wang

Publications and source records attributed to Weixu Wang.

6 recordsLinked to original sources

arXiv2026

DuplexDrama: A Synthesized Dialogue Dataset with Scenarios, Full-Duplex Behaviors, Expressive Speech, and Sound Events

We present DuplexDrama, the first synthesized spoken dialogue dataset that simultaneously covers four dimensions: (i) complete persona and scenario settings; (ii) three full-duplex behaviors (interruption, backchannel, incomplete); (iii) expressive speech with persona-aligned emotion labels; and (iv) script-aware sound events. DuplexDrama is built via a 4-stage pipeline; quality validation on both scripts and synthesized audio confirms its quality. We have produced more than 2,000 hours audio data with a 64-voice timbre pool spanning 13 personas and 5 age buckets; 3.8% of all turns carry at least one full-duplex behavior. This data has been validated through internal full-duplex model training. We will release a curated subset of 6,400 bilingual dialogues (800 h, Chinese ~500 h + English ~300 h) to advance full-duplex spoken dialogue model research. Data samples are available at our demo page and LLM-judge evaluation prompts will be released with the dataset.

cs.CL↗

arXiv2026

Same Words, Different Actions: Paired Turn-Taking Evaluation under Rewritten Dialogue Contexts

Real-time spoken dialogue systems must distinguish interruptions that require yielding the floor from backchannels that permit continued speaking. Existing benchmarks typically score events independently and may therefore assign high scores to systems with fixed action preferences rather than context-sensitive decision policies. We introduce ECHO, a paired diagnostic benchmark for Chinese turn-taking evaluation. ECHO pairs examples with the same overlap transcript but contrasting preceding multi-turn dialogue contexts, with one requiring Yield and the other Keep. It additionally includes off-talk examples for diagnosing unnecessary yielding. We introduce pair accuracy, which requires correct decisions on both members of a pair and assigns no credit to constant-action policies. Experiments on four speech systems show that three exhibit a severe over-yielding bias: they correctly keep the floor on fewer than 13% of backchannels, resulting in near-zero pairwise success rates equal or less than 4%. While the remaining system remains comparatively balanced across contexts, these findings broadly demonstrate that interruption-only evaluation can severely overestimate practical turn-taking reliability.

cs.CL↗

arXiv2026

AdaptDuplex: from static to adaptive full-duplex spoken dialogue

Full-duplex spoken dialogue requires simultaneous listening and speaking at sub-second latency, under conversational timing and cognitive demands that change moment to moment. Yet current models mostly impose static operating points, lacking a systematic mechanism for adaptive decisions. We present AdaptDuplex, which upgrades Qwen3-Omni with such a mechanism, co-designed across three layers. A compact token-level protocol represents every window as a canonical sequence, trains dual-stream alignment through a bounded text lead over speech, and exposes every behavioral decision as an explicit token for training-free runtime control via logits bias. Adaptive mechanisms dynamically predict among discrete window durations and augment direct response as needed with non-blocking cognitive consolidation and multi-flight external reasoning. A progressive pipeline introduces these behaviors through a three-stage Thinker curriculum, then Talker-only and joint SFT, with GRPO as a further increment. On Full-Duplex-Bench v1 and v1.5, AdaptDuplex outperforms DuplexOmni and MiniCPM-o 4.5 on the majority of comparable turn-taking, overlap-behavior, and timing metrics, with gains in both interaction decisions and response timing. On the human-recorded HumDial-FDBench, it attains the highest Final score (72.9) of the compared duplex models.

cs.SD↗

arXiv2026

CellForge: Agentic Design of Virtual Cell Models

Virtual cell modeling aims to predict cellular responses to diverse perturbations but faces challenges from biological complexity, multimodal data heterogeneity, and the need for interdisciplinary expertise. We introduce CellForge, a multi-agent framework that autonomously designs and synthesizes neural network architectures tailored to specific single-cell datasets and perturbation tasks. Given raw multi-omics data and task descriptions, CellForge discovers candidate architectures through collaborative reasoning among specialized agents, then generates executable implementations. Our core contribution is the framework itself: showing that multi-agent collaboration mechanisms - rather than manual human design or single-LLM prompting - can autonomously produce executable, high-quality computational methods. This approach goes beyond conventional hyperparameter tuning by enabling entirely new architectural components such as trajectory-aware encoders and perturbation diffusion modules to emerge from agentic deliberation. We evaluate CellForge on six datasets spanning gene knockouts, drug treatments, and cytokine stimulations across multiple modalities (scRNA-seq, scATAC-seq, CITE-seq). The results demonstrate that the models generated by CellForge are highly competitive with established baselines, while revealing systematic patterns of architectural innovation. CellForge highlights the scientific value of multi-agent frameworks: collaboration among specialized agents enables genuine methodological innovation and executable solutions that single agents or human experts cannot achieve. This represents a paradigm shift toward autonomous scientific method development in computational biology. Code is available at https://github.com/gersteinlab/CellForge.

cs.LG↗

arXiv2025

CometNet: Contextual Motif-guided Long-term Time Series Forecasting

Long-term Time Series Forecasting is crucial across numerous critical domains, yet its accuracy remains fundamentally constrained by the receptive field bottleneck in existing models. Mainstream Transformer- and Multi-layer Perceptron (MLP)-based methods mainly rely on finite look-back windows, limiting their ability to model long-term dependencies and hurting forecasting performance. Naively extending the look-back window proves ineffective, as it not only introduces prohibitive computational complexity, but also drowns vital long-term dependencies in historical noise. To address these challenges, we propose CometNet, a novel Contextual Motif-guided Long-term Time Series Forecasting framework. CometNet first introduces a Contextual Motif Extraction module that identifies recurrent, dominant contextual motifs from complex historical sequences, providing extensive temporal dependencies far exceeding limited look-back windows; Subsequently, a Motif-guided Forecasting module is proposed, which integrates the extracted dominant motifs into forecasting. By dynamically mapping the look-back window to its relevant motifs, CometNet effectively harnesses their contextual information to strengthen long-term forecasting capability. Extensive experimental results on eight real-world datasets have demonstrated that CometNet significantly outperforms current state-of-the-art (SOTA) methods, particularly on extended forecast horizons.

cs.CE↗

arXiv2025

A scalable gene network model of regulatory dynamics in single cells

Single-cell data provide high-dimensional measurements of the transcriptional states of cells, but extracting insights into the regulatory functions of genes, particularly identifying transcriptional mechanisms affected by biological perturbations, remains a challenge. Many perturbations induce compensatory cellular responses, making it difficult to distinguish direct from indirect effects on gene regulation. Modeling how gene regulatory functions shape the temporal dynamics of these responses is key to improving our understanding of biological perturbations. Dynamical models based on differential equations offer a principled way to capture transcriptional dynamics, but their application to single-cell data has been hindered by computational constraints, stochasticity, sparsity, and noise. Existing methods either rely on low-dimensional representations or make strong simplifying assumptions, limiting their ability to model transcriptional dynamics at scale. We introduce a Functional and Learnable model of Cell dynamicS, FLeCS, that incorporates gene network structure into coupled differential equations to model gene regulatory functions. Given (pseudo)time-series single-cell data, FLeCS accurately infers cell dynamics at scale, provides improved functional insights into transcriptional mechanisms perturbed by gene knockouts, both in myeloid differentiation and K562 Perturb-seq experiments, and simulates single-cell trajectories of A549 cells following small-molecule perturbations.

q-bio.MN↗