arXiv subjects

Xiaoyu Wang

Publications and source records attributed to Xiaoyu Wang.

At least 37 records · Page 2Linked to original sources

arXiv2026

MedCollab: IBIS-Guided Multi-Agent Collaboration with Hierarchical Disease Relation Chains for Clinical Diagnosis

Clinical diagnosis is a gradual process of evidence integration, in which physicians move from symptoms and medical history to examinations, competing hypotheses, disease relations, and treatment decisions. Large language models have advanced medical text understanding and generation. Yet their clinical use remains limited by weak evidence grounding, opaque reasoning, and inconsistent links among differential diagnosis, final diagnosis, diagnostic basis, and treatment planning. We introduce MedCollab, a multi-agent framework for full-cycle clinical diagnosis and report generation. MedCollab coordinates specialist and examination agents according to patient records. It structures agent deliberation with an Issue-Based Information System (IBIS) protocol, so that each diagnostic position is supported by patient-specific evidence and medical knowledge. It also builds Hierarchical Disease Relation Chains (HDRC) to connect accepted hypotheses through progression, complication, and comorbidity relations. During multi-round deliberation, a verifier-guided consensus module evaluates evidence support, medical plausibility, and logical conflicts. It then adjusts agent contributions and filters unsupported reasoning. Experiments on ClinicalBench and MIMIC-IV show that MedCollab outperforms leading LLMs and medical multi-agent baselines in diagnostic accuracy, evidence consistency, and clinical reasoning quality. These results indicate that structured and auditable collaboration can produce more faithful and clinically coherent diagnostic reports.

cs.MA↗

arXiv2026

Variance-Optimal Hedging in the Rough Hawkes--Heston Model

We study variance-optimal stock hedging and the convergence of approximate strategies in the rough Hawkes--Heston model. Starting from the model's affine conditional transform and the affine Volterra jump framework, we obtain semi-explicit hedges for European calls and a representation of the minimum quadratic error through the Galtchouk--Kunita--Watanabe projection. Our main approximation result keeps the original stock, variance driver, and information flow fixed while regularizing the kernel used to evaluate the hedge. To handle singular memory and common marked jumps, we construct the approximate holdings from histories available before trading and preserve the conditional transform's random modulus envelope. Riccati--Volterra stability and weighted truncation then yield convergence in the original stock's trading norm on compact Fourier intervals. For calls, a joint choice of kernel regularization and Fourier cutoff gives convergence of the initial capitals and strategies, uniform-in-time square-mean convergence of continuous-time gains, and convergence of the terminal mean-square error to the variance-optimal value. A numerical experiment with shifted fractional kernels illustrates the construction on common original-market paths.

q-fin.MF↗

arXiv2026

ToSCA: Leveraging Hierarchical Reinforcement Learning on Temporal and Strategic Abstractions of Conversational Agents

Humans naturally exhibit multiple forms of abstraction in reasoning and interaction, including temporal abstraction across decision timescales and strategic abstraction over communicative intents. Inspired by these complementary abstractions, we propose a two-level hierarchical reinforcement learning (HRL) framework for conversational agents that bridges the gap between existing token-level and utterance-level RL methods. Built upon a two-level Markov decision process (MDP), our framework conditions token-level response generation on utterance-level actions represented by explicit textual strategies. Based on theoretical analysis and efficiency considerations, we employ DQN to optimize the high-level Q-network and PPO to train the low-level actor-critic. To further alleviate reward sparsity and facilitate convergence, we introduce a dual-granularity reward mechanism that combines the utterance-level satisfaction score with token-level intrinsic self-consistency and a KL-divergence penalty. Experiments on both daily-life and emotional support conversations demonstrate that our method consistently outperforms a wide range of baselines in both strategy determination and response quality. Our implementation is available at https://github.com/AaronJi/ToSCA.

cs.CL↗

arXiv2026

Polarizable atomic multipoles for learning long-range electrostatics

Long-range electrostatics and polarization remain central obstacles to extending machine learning interatomic potentials (MLIPs) to ionic, polar, and interfacial systems. Here we introduce a semi-local framework for learning electrostatics from energies and forces using polarizable atomic multipoles. Local equivariant descriptors predict environment-dependent latent monopoles, dipoles, and quadrupoles, while residual non-local charge transfer and polarization are captured by non-self-consistent linear response in induced charges and dipoles. Across four diverse benchmarks and four short-range MLIP architectures, the multipole hierarchy and response terms systematically improve potential energy surface accuracy, with the largest gains in systems where long-range effects are essential. More importantly, physically meaningful electrical responses emerge without direct supervision. The learned latent multipoles yield accurate Born effective charge tensors and infrared spectra in close agreement with experiments. The induced-dipole extension introduces new capabilities: it predicts polarizabilities and thereby enables semi-quantitative Raman spectra for bulk water and hybrid MAPbI$_3$ perovskite, as well as the essential features of the surface-specific vibrational sum-frequency generation spectrum at the water-air interface. In ferroelectric HfO$_2$, the predicted electrical response also captures LO-TO splitting and polarization switching. This systematically improvable, physically transparent framework enables MLIPs trained on standard energy and force labels to predict polarization-sensitive observables.

cond-mat.mtrl-sci↗

arXiv2026

Long-Run Dynamics of AdaGrad-Norm: Trajectory Stability and Asymptotic Stationarity

AdaGrad-Norm is widely studied, yet its long-run behavior in smooth nonconvex optimization remains delicate. For the standard current-denominator recursion, the same stochastic gradient determines both the update and its normalizer, rendering the effective stepsize nonpredictable. At the square-root normalization, the quadratic smoothness budget admits only logarithmic control rather than a uniform summability bound. We establish trajectory stability and full-sequence asymptotic stationarity directly for this unmodified recursion. Under global smoothness, non-flatness at infinity, conditional unbiasedness, and an affine conditional second-moment bound, we prove $\E[\sup_{n\geq1} g(θ_n)]<\infty$ and $\E[\sup_{n\geq1}\|θ_n\|]<\infty$, without assuming bounded iterates. For stationarity, we use a local conditional relative-moment condition that permits unbounded oracle values and covers fixed-size finite-sum mini-batches and locally nondegenerate additive noise. Together with a weak Sard condition, it yields $\|\nabla g(θ_n)\|\to0$ almost surely and $\E\|\nabla g(θ_n)\|^2\to0$. The proof combines a current-sample Lyapunov correction, a stopped-excursion stability argument, and finite-window control for the actual nonpredictable stepsize. We also analyze power normalization with $q>1/2$, where the quadratic normalization budget is summable, identifying $q=1/2$ as the boundary of the proof mechanism developed here rather than a universal algorithmic phase transition.

math.OC↗

arXiv2026

Towards World Models in Biomedical Research

A central goal of biomedicine is to understand, predict and ultimately control the dynamic mechanisms by which biological systems respond to perturbations, disease progression and therapeutic intervention. Although foundation models and large language models have accelerated biomedical data interpretation, most current systems remain focused on static pattern recognition rather than prospective simulation of biological futures. Here we propose biomedical world models as a paradigm for AI-driven discovery. These models learn latent representations of molecular, cellular, tissue and clinical states, together with intervention-conditioned dynamics that allow future trajectories to be simulated before actions are taken. We discuss how biomedical world models could function as data engines, environment simulators and scientific planning substrates across applications including virtual cells, organoids, virtual patients and surgical simulation. We outline the data infrastructure, evaluation benchmarks, safety constraints and governance frameworks required. Biomedical world models may provide a foundation for simulation-guided, closed-loop and experimentally actionable biomedical discovery.

cs.AI↗

arXiv2026

Improved Analysis for Hessian-free High-resolution Monte Carlo Sampling

Hessian-free high-resolution (HFHR) dynamics augments underdamped Langevin dynamics (ULD) with reversible position diffusion for sampling problems that arise in machine learning. We establish an explicit quantitative contraction rate for HFHR dynamics under a position Poincaré inequality, weighted Hessian and Laplacian bounds, and a compact Sobolev embedding, where the potential function is not necessarily convex. An adapted time-augmented Poincaré inequality yields an explicit rate that improves upon the contraction rate of the underdamped Langevin dynamics. We also give a weak-solution construction and a self-contained spectral proof of the divergence lemma underlying the argument. For HFHR Monte Carlo (HFHRMC) algorithm, which is based on a discretization scheme of HFHR dynamics, we use a path-space Girsanov argument to obtain a non-asymptotic convergence bound and an explicit iteration complexity in total variation distance. The bounds hold for every $α\geq0$ and $γ>0$ and remain regular at the ULD endpoint. Optimizing the iteration complexity bound yields a positive, accuracy-dependent position-diffusion parameter at finite accuracy, while its leading high-accuracy order coincides with that of the optimized ULD endpoint. Our iteration complexity bound improves upon the existing work on HFHR algorithms. Numerical experiments including Bayesian learning problems on real data are provided to illustrate the effect of positive $α$ and its benefit.

stat.ML↗

arXiv2026

Unit-to-Plant Stability Shaping of Multi-Electrolyzer ReP2H Plants via Interface Design and Dispatch

Alkaline water electrolysis (AWE) units supplied by insulated gate bipolar transistor rectifiers (IGBT-Rs) may experience oscil-lations caused by coupling between rectifier control and electro-lyzer (ELZ) dynamics. Because this risk varies with unit loading and power allocation, production-oriented dispatch may place a multi-ELZ renewable power-to-hydrogen (ReP2H) plant near or exceed its stability boundary. This paper proposes a stability-oriented framework for control design and plant production dis-patch. A three-port admittance model links the ac port, dc link, and electrolysis stack. Unit-level dc-port analysis quantifies the effects of loading, temperature, Buck bandwidth, and dc-link capacitance, while plant-level aggregation evaluates how unit commitment and power allocation affect stability. Results show that higher loading reduces stability, whereas larger dc-link ca-pacitance and higher Buck bandwidth improve it. Under the same plant loading, different power allocations result in different plant-level stability margins, with balanced allocation generally providing a larger margin than concentrated allocation. The plant-level model thus distinguishes the stability margins of ad-missible schedules. Hardware-in-the-loop (HIL) tests validate these trends and the proposed redistribution rule. The resulting operating regions and dispatch rules can be used to screen unit commitment and power allocation decisions in plant production scheduling.

math.OC↗

arXiv2026

Hydrogen-helium immiscibility boundary in gas-giant planetary interiors from machine-learning molecular dynamics

The location of the hydrogen-helium (H/He) immiscibility boundary controls whether and where helium rain occurs in giant planets, yet it remains uncertain because high-pressure experiments are challenging and ab initio simulations are limited in system size and simulation time. We map this boundary by computing composition-dependent chemical potentials from large-scale molecular dynamics driven by machine learning potentials trained on three density functional approximations (PBE, vdW-DF, and the hybrid HSE). Across the pressure range of 100-1000 GPa, the demixing temperatures are typically ~2000 K lower than previous ab initio simulations using small system sizes, and this discrepancy is larger than the estimated error from the chosen density functionals, machine learning potentials, neglect of nuclear quantum effects, and statistical uncertainties. Fitting the H/He mixing free energy to a Redlich-Kister regular solution model rationalizes the thermodynamic driving force for phase separation and provides a predictive representation of the boundary. Comparing with current planetary interior profiles indicates that helium rain is plausible in Saturn but unlikely in the warmer interior of Jupiter. Our results narrow the uncertainty in the H/He immiscibility boundary and provide inputs for planetary models that couple demixing, heat transport, and composition gradients in gas giants.

astro-ph.EP↗

arXiv2026

FAR-DPO: Feasibility-Aware and Robust Direct Preference Optimization for Cyclic Peptide Design

Cyclic peptides are emerging as promising molecular scaffolds in drug discovery due to their high binding affinity and structural stability. However, extending generative models from linear to cyclic peptide design remains challenging, as cyclization sharply restricts the feasible design space through coupled geometric and biophysical constraints. Moreover, limited training data has led existing approaches to rely largely on zero-shot generation or post hoc filtering, resulting in low yields of feasible designs and limited control over multi-objective trade-offs. To address these limitations, we propose FAR-DPO (Feasibility-Aware and Robust Direct Preference Optimization), an architecture-agnostic framework that steers generative models toward structurally and biophysically feasible cyclic peptide designs, particularly for challenging targets. FAR-DPO integrates feasibility-aware preference construction with difficulty-aware group-robust optimization. Specifically, it constructs within-target preference pairs through feasibility-gated multi-objective dominance and adaptively reweights predefined difficulty groups according to their current preference losses. On the CPSea LNR benchmark, under a fixed generation budget, FAR-DPO increases overall success rate from 46.89% to 57.79% on PepGLAD and from 47.96% to 49.57% on PepFlow. These gains also extend to the hardest target quartile and are accompanied by more favorable best-per-target binding scores. Together, these results demonstrate FAR-DPO's effectiveness in improving feasibility and target-wise robustness.

cs.LG↗

arXiv2026

Beyond Residual Connections: Manifold-Constrained Hyper-Connections for Robust Speaker Representation Learning

Residual connections are fundamental to deep speaker recogni- tion models, such as ECAPA-TDNN and ResNet. However, standard identity mapping limits information flow to a sin- gle path, constraining representation capacity. We introduce Manifold-Constrained Hyper-Connections (mHC), reformulat- ing residual paths as a multi-stream evolution where informa- tion is mixed through a doubly stochastic matrix. By employing Sinkhorn-Knopp iterations, mHC ensures energy conservation by preserving signal intensity and feature mean, which stabi- lizes gradients and mitigates signal degradation in complex net- works. We evaluate mHC by replacing standard residual con- nections in backbones including ECAPA-TDNN, ResNet-34, Res2Net, and E-Res2Net. Extensive experiments on VoxCeleb1 demonstrate that mHC connections consistently enhance per- formance across all architectures, highlighting its effectiveness for robust speaker representation learning.

cs.SD↗

arXiv2026

FDDWAN: A Frequency-Decoupled Diffusion Network for Watermarking Attack

Existing invisible watermark removal methods often struggle to accurately capture the watermark-bearing features, leading to an unfavorable trade-off between watermark suppression and perceptual fidelity. In this paper, we propose the Frequency-Decoupled Diffusion Watermark Attack Network (FDDWAN), a coarse-to-fine framework that performs watermark removal through wavelet-domain decomposition and residual diffusion refinement. In the initial stage, the Wavelet-based Frequency-domain Preliminary Attack Module (WFPAM) decomposes the watermarked image into low- and high-frequency subbands and applies frequency-specific attack strategies tailored to their respective contributions to watermark robustness and perceptual quality. In the next stage, the Frequency-domain Residual Diffusion Attack Module (FRDAM) separately models the residual distributions between the preliminarily attacked outputs and the corresponding watermark-free references during training. Rather than reconstructing the entire image, FRDAM selectively refines frequency-domain residuals, directing the diffusion process toward the remaining watermark related discrepancies while minimizing modifications to image content. Extensive experiments on CelebA and ImageNet across four representative watermarking schemes demonstrate that FDDWAN achieves a more favorable trade-off between watermark removal effectiveness and visual fidelity than conventional and learning-based attack methods.

cs.CV↗

arXiv2026

OpFlow: Learning Opportunity-Conditioned Choice Potentials for Robust OD Flow Prediction

Origin-destination (OD) flow prediction is central to urban analytics, yet deep models trained on raw counts remain vulnerable to distribution shift. The core problem is that raw count supervision cannot distinguish transferable choice mechanisms from environment-specific shortcuts. Raw OD count mixes two objects: how much demand an origin produces and how that demand is allocated across destinations. We argue that the transferable object is the exposure-to-choice law that maps spatial conditions to relative destination preferences. We propose OpFlow, a mechanism-constrained framework that learns row-centered choice potentials and reconstructs flows by combining the induced allocation with a separately calibrated origin scale. Under distribution shift, spatial exposures and the induced allocations are allowed to vary; what transfers is the conditional map from exposure states to relative choice potentials. Theoretically, we characterize the identifiable row-centered potential and show that classical spatial interaction laws are restricted log-potential cases. Controlled synthetic shifts and a real-world experiment show OpFlow improves robustness under environment shifts.

cs.LG↗

arXiv2026

Revisiting Decentralized Online Convex Optimization with Compressed Communication

Decentralized online convex optimization (D-OCO) is a popular framework for distributed applications with streaming data. To tackle the communication bottleneck, previous studies have investigated D-OCO with compressed communication and proposed several algorithms that are variants of online gradient descent (OGD). However, for D-OCO with exact communication, the best existing algorithms are variants of follow-the-regularized-leader (FTRL). In this paper, for the first time, we propose two FTRL-type algorithms for D-OCO with compressed communication. Compared with OGD-type algorithms, our algorithms are more elegant in both algorithmic design and theoretical analysis. The key insight is that the dual update mechanism of FTRL allows us to make a simple application of the technique for average consensus with communication compression. More specifically, our first algorithm considers the full-information setting, and can match the existing regret bounds. Our second algorithm is designed for the bandit setting, and can significantly improve both the regret bounds and communication costs of existing algorithms.

cs.LG↗

arXiv2026

EO-VGGT: Orbital Ray-Conditioned 3D Foundation Models for Satellite Multi-View Reconstruction

In the era of satellite constellations, multi-view optical satellite imagery is pivotal for Earth Observation (EO) and high-quality Digital Surface Model (DSM) reconstruction. Although feed-forward 3D foundation models have transformed computer vision, their deployment in satellite remote sensing is inherently constrained by the structural discrepancy between implicit perspective assumptions and explicit orbital pushbroom geometry. This geometric incongruity is further compounded by pronounced view-set heterogeneity. We present EO-VGGT, a framework that adapts a frozen perspective-driven model to orbital observations via explicit physical geometry embedding.First, the Geometry-Correlation Constrained Selection (GCCS) strategy prunes sub-optimal observations by balancing geometric diversity and radiometric consistency to optimize the input sequence. Second, a Sensor-Ray Encoder (SRE) parameterizes pixel-level pushbroom lines of sight derived from the Rational Function Model (RFM) into high-dimensional space-geometric tokens, reconciling the mathematical discrepancy between central projection and orbital kinematics. Third, a lightweight Ray-Pointing-Aware Adapter (RPAA) employs gated residual blocks to integrate these tokens directly into the frozen transformer backbone. Our findings underscore that integrating explicit physical geometry with optimized view selection is essential for robust feed-forward satellite 3D reconstruction.

cs.CV↗

arXiv2026

Variance Reduction for Stochastic Gradient Generalized Non-reversible Langevin Monte Carlo Algorithms

We study the leading-order fluctuation of stochastic gradient Euler-Maruyama estimators for generalized non-reversible Langevin dynamics. Under structural assumptions tailored to the small-stepsize central limit theorem and under an unbiased stochastic gradient oracle, we prove that the empirical average over a horizon of order the inverse squared stepsize satisfies a central limit theorem in the vanishing-stepsize regime. The limiting variance is characterized through the Poisson equation of the limiting full-gradient diffusion. We then rewrite this constant in an operator form that links it to the continuous-time asymptotic variance and, under standard operator-theoretic assumptions, derive a sufficient condition under which an anti-symmetric perturbation strictly reduces the leading-order fluctuation constant relative to the reversible baseline. We also identify bounded smooth predictive observables that re directly covered by the main theorem. As a separate Gaussian calculation beyond the bounded-test-function regime, we obtain closed-form formulas for quadratic Hamiltonians and linear observables. The framework covers non-reversible Langevin dynamics and augmented-state examples including Hessian-free high-resolution dynamics and a positive-definite subclass of gradient-adjusted underdamped Langevin dynamics that allow stochastic gradients. Numerical experiments on basic examples and Bayesian linear regression using synthetic data, and Bayesian logistic regression using real data support the predicted Gaussian fluctuations and show that the non-reversible schemes consistently reduce the root mean squared error (RMSE) relative to their reversible baselines.

stat.ML↗

arXiv2026

A pilot study examining transcranial photobiomodulation therapy intervention in college students with insomnia

College students commonly report insufficient sleep and poor sleep quality, with ~30% meeting insomnia criteria, posing significant threats to their physical growth, cognitive development, and overall well-being, as well as imposing a substantial economic burden on society [1]. The hyperarousal model of insomnia [2] emphasizes that hyperarousal across cognitive, emotional, and physiological domains mutually reinforces one another. Neuroimaging studies have further identified prefrontal hypoactivity as a key neural substrate underlying these dysfunctional cognitions and elevated arousal, reflecting a failure of top-down modulatory control over both limbic reactivity [3] and brainstem arousal nuclei [4]. Moreover, transcranial photobiomodulation (tPBM) therapy targeting the prefrontal cortex has demonstrated therapeutic efficacy across neuropsychiatric disorders with insomnia comorbidities [5,6], providing preliminary support for its application in insomnia. However, the neuro mechanisms underlying tPBM's therapeutic effects on insomnia remain to be elucidated.

q-bio.NC↗

arXiv2026

EmoFSM: A Finite State Machine for Emotional Support Conversation

Emotional support conversation (ESC) aims to alleviate people's emotional distress through effective conversations. Although large language models (LLMs) have made remarkable progress in ESC, most of these studies may not define the diagram from a state-model perspective, thereby providing a suboptimal solution for long-term satisfaction. To address such an issue, we leverage the Finite State Machine (FSM) on LLMs, and propose a framework called EmoFSM. Our framework allows a single LLM to bootstrap the planning during ESC, and self-reason the seeker's emotion, support strategy, and the final response upon each conversation turn. Substantial experiments in ESC datasets suggest that EmoFSM outperforms many baselines, including direct inference, self-fine, chain of thought, finetuning, and externally supported methods, even those with many more parameters.

cs.CL↗