DinoMUSE: A DINOv2-guided Framework for Unsupervised Lateral Motion Estimation in Ultrasound Elastography
Quasi-static ultrasound elastography (USE) is a non-invasive imaging method for assessing soft tissue mechanical properties. Limited by low resolution, low sampling frequency and lack of phase information in the lateral direction, accurate lateral motion estimation remains a critical bottleneck in USE. Existing methods mainly rely on local image matching and physical constraints (such as tissue incompressibility assumption and effective Poisson's ratio), which lack sufficient contextual information. We present DinoMUSE, a DINO-guided mixture-of-experts (MoE) framework for unsupervised lateral motion estimation in USE. DinoMUSE incorporates high-level visual representations learned by DINOv2 into the motion estimation network to provide global contextual guidance. To facilitate effective interaction between DINOv2 features and local matching features, an MoE-based feature-fusion module adaptively transforms and integrates the two representations. Evaluations against NCC, GLUE, RAFT, and sPICTURE on simulation and in-vivo breast datasets show that DinoMUSE substantially improves lateral estimation accuracy while maintaining competitive axial performance. Specifically, DinoMUSE reduces the mean square error (MSE) of lateral displacement and strain estimation by 60% and 65%, respectively, compared with a SOTA algorithm on the simulation dataset. For in-vivo breast data, DinoMUSE achieves axial strain SNR and CNR of 5.70 and 4.82, and lateral strain SNR and CNR of 4.61 and 2.23, compared to 4.11 and 3.32, and 4.57 and 2.13 for the best competing method, alongside improved lesion visualization. These findings indicate the potential of leveraging transferable visual representations and adaptive feature fusion to improve lateral motion estimation in USE. The code is available at xxxxxxxx.