arXiv subjects

Ya Zhang

Publications and source records attributed to Ya Zhang.

At least 55 records · Page 3Linked to original sources

arXiv2026

PhenoLIP: Integrating Phenotype Ontology Knowledge into Medical Vision-Language Pretraining

Recent progress in large-scale CLIP-like vision-language models(VLMs) has greatly advanced medical image analysis. However, most existing medical VLMs still rely on coarse image-text contrastive objectives and fail to capture the systematic visual knowledge encoded in well-defined medical phenotype ontologies. To address this gap, we construct PhenoKG, the first large-scale, phenotype-centric multimodal knowledge graph that encompasses over 520K high-quality image-text pairs linked to more than 3,000 phenotypes. Building upon PhenoKG, we propose PhenoLIP, a novel pretraining framework that explicitly incorporates structured phenotype knowledge into medical VLMs through a two-stage process. We first learn a knowledge-enhanced phenotype embedding space from textual ontology data and then distill this structured knowledge into multimodal pretraining via a teacher-guided knowledge distillation objective. To support evaluation, we further introduce PhenoBench, an expert-verified benchmark designed for phenotype recognition, comprising over 7,800 image--caption pairs covering more than 1,000 phenotypes. Extensive experiments demonstrate that PhenoLIP outperforms previous state-of-the-art baselines, improving upon BiomedCLIP in phenotype classification accuracy by 8.85\% and BIOMEDICA in cross-modal retrieval by 15.03%, underscoring the value of integrating phenotype-centric priors into medical VLMs for structured and interpretable medical image understanding.

cs.CV↗

arXiv2026

LegalOne: A Family of Foundation Models for Reliable Legal Reasoning

While Large Language Models (LLMs) have demonstrated impressive general capabilities, their direct application in the legal domain is often hindered by a lack of precise domain knowledge and complexity of performing rigorous multi-step judicial reasoning. To address this gap, we present LegalOne, a family of foundational models specifically tailored for the Chinese legal domain. LegalOne is developed through a comprehensive three-phase pipeline designed to master legal reasoning. First, during mid-training phase, we propose Plasticity-Adjusted Sampling (PAS) to address the challenge of domain adaptation. This perplexity-based scheduler strikes a balance between the acquisition of new knowledge and the retention of original capabilities, effectively establishing a robust legal foundation. Second, during supervised fine-tuning, we employ Legal Agentic CoT Distillation (LEAD) to distill explicit reasoning from raw legal texts. Unlike naive distillation, LEAD utilizes an agentic workflow to convert complex judicial processes into structured reasoning trajectories, thereby enforcing factual grounding and logical rigor. Finally, we implement a Curriculum Reinforcement Learning (RL) strategy. Through a progressive reinforcement process spanning memorization, understanding, and reasoning, LegalOne evolves from simple pattern matching to autonomous and reliable legal reasoning. Experimental results demonstrate that LegalOne achieves state-of-the-art performance across a wide range of legal tasks, surpassing general-purpose LLMs with vastly larger parameter counts through enhanced knowledge density and efficiency. We publicly release the LegalOne weights and the LegalKit evaluation framework to advance the field of Legal AI, paving the way for deploying trustworthy and interpretable foundation models in high-stakes judicial applications.

cs.CL↗

arXiv2026

End-to-End Agentic RAG System Training for Traceable Diagnostic Reasoning

The integration of Large Language Models (LLMs) into healthcare is constrained by knowledge limitations, hallucinations, and a disconnect from Evidence-Based Medicine (EBM). While Retrieval-Augmented Generation (RAG) offers a solution, current systems often rely on static workflows that miss the iterative, hypothetico-deductive reasoning of clinicians. To address this, we introduce Deep-DxSearch, an agentic RAG system trained end-to-end via reinforcement learning (RL) for traceable diagnostic reasoning. Deep-DxSearch acts as an active investigator, treating the LLM as an agent within an environment of 16,000+ guideline-derived disease profiles, 150,000+ patient records for case-based reasoning, and over 27 million biomedical documents. Using soft verifiable rewards that co-optimize retrieval and reasoning, the model learns to formulate queries, evaluate evidence, and refine searches to close diagnostic gaps. Experiments show our end-to-end RL framework consistently outperforms prompt-engineering and training-free RAG methods. On in-distribution (ID) and out-of-distribution (OOD) benchmarks for common and rare diseases, Deep-DxSearch surpasses strong baselines-including GPT-4o, DeepSeek-R1, and medical-specific frameworks-achieving an average accuracy gain of 22.7% over the second-best model. In validation with 150 real-world cases, Deep-DxSearch boosts physicians' average diagnostic accuracy from 45.6% to 69.1%. These results indicate that evolving agentic systems to leverage statistical regularities in large-scale healthcare data is key for trustworthy diagnostic assistants. All data, code, and checkpoints are available at https://qiaoyu-zheng.github.io/Deep-DxSearch.

cs.CL↗

arXiv2026

Knowledge-enhanced Pretraining for Vision-language Pathology Foundation Model on Cancer Diagnosis

Vision-language foundation models have shown great promise in computational pathology but remain primarily data-driven, lacking explicit integration of medical knowledge. We introduce KEEP (KnowledgE-Enhanced Pathology), a foundation model that systematically incorporates disease knowledge into pretraining for cancer diagnosis. KEEP leverages a comprehensive disease knowledge graph encompassing 11,454 diseases and 139,143 attributes to reorganize millions of pathology image-text pairs into 143,000 semantically structured groups aligned with disease ontology hierarchies. This knowledge-enhanced pretraining aligns visual and textual representations within hierarchical semantic spaces, enabling deeper understanding of disease relationships and morphological patterns. Across 18 public benchmarks (over 14,000 whole-slide images) and 4 institutional rare cancer datasets (926 cases), KEEP consistently outperformed existing foundation models, showing substantial gains for rare subtypes. These results establish knowledge-enhanced vision-language modeling as a powerful paradigm for advancing computational pathology.

eess.IV↗

arXiv2026

Control of Electron Energy Distribution Functions by Current Waveform Tailoring in Inductively Coupled Radio Frequency Plasmas

Based on two-dimensional particle-in-cell simulations a novel approach towards Electron Energy Probability Function (EEPF) and plasma chemistry control by Current Waveform Tailoring (CWT) in the coil of inductively coupled discharges is proposed. Varying the shape of this current waveform provides electrical control of the dynamics of the electric field in the plasma. Using sawtooth instead of sinusoidal waveforms allows breaking and controlling the temporal symmetry of the electric field dynamics. In this way CWT allows controlling the EEPF, the ionization-to-excitation rate ratio, and the plasma chemistry.

physics.plasm-ph↗

arXiv2025

Automatic Reward Shaping from Multi-Objective Human Heuristics

Designing effective reward functions remains a central challenge in reinforcement learning, especially in multi-objective environments. In this work, we propose Multi-Objective Reward Shaping with Exploration (MORSE), a general framework that automatically combines multiple human-designed heuristic rewards into a unified reward function. MORSE formulates the shaping process as a bi-level optimization problem: the inner loop trains a policy to maximize the current shaped reward, while the outer loop updates the reward function to optimize task performance. To encourage exploration in the reward space and avoid suboptimal local minima, MORSE introduces stochasticity into the shaping process, injecting noise guided by task performance and the prediction error of a fixed, randomly initialized neural network. Experimental results in MuJoCo and Isaac Sim environments show that MORSE effectively balances multiple objectives across various robotic tasks, achieving task performance comparable to those obtained with manually tuned reward functions.

cs.LG↗

arXiv2025

RAD: Towards Trustworthy Retrieval-Augmented Multi-modal Clinical Diagnosis

Clinical diagnosis is a highly specialized discipline requiring both domain expertise and strict adherence to rigorous guidelines. While current AI-driven medical research predominantly focuses on knowledge graphs or natural text pretraining paradigms to incorporate medical knowledge, these approaches primarily rely on implicitly encoded knowledge within model parameters, neglecting task-specific knowledge required by diverse downstream tasks. To address this limitation, we propose Retrieval-Augmented Diagnosis (RAD), a novel framework that explicitly injects external knowledge into multimodal models directly on downstream tasks. Specifically, RAD operates through three key mechanisms: retrieval and refinement of disease-centered knowledge from multiple medical sources, a guideline-enhanced contrastive loss that constrains the latent distance between multi-modal features and guideline knowledge, and the dual transformer decoder that employs guidelines as queries to steer cross-modal fusion, aligning the models with clinical diagnostic workflows from guideline acquisition to feature extraction and decision-making. Moreover, recognizing the lack of quantitative evaluation of interpretability for multimodal diagnostic models, we introduce a set of criteria to assess the interpretability from both image and text perspectives. Extensive evaluations across four datasets with different anatomies demonstrate RAD's generalizability, achieving state-of-the-art performance. Furthermore, RAD enables the model to concentrate more precisely on abnormal regions and critical indicators, ensuring evidence-based, trustworthy diagnosis. Our code is available at https://github.com/tdlhl/RAD.

cs.LG↗

arXiv2025

SceneGen: Single-Image 3D Scene Generation in One Feedforward Pass

3D content generation has recently attracted significant research interest, driven by its critical applications in VR/AR and embodied AI. In this work, we tackle the challenging task of synthesizing multiple 3D assets within a single scene image. Concretely, our contributions are fourfold: (i) we present SceneGen, a novel framework that takes a scene image and corresponding object masks as input, simultaneously producing multiple 3D assets with geometry and texture. Notably, SceneGen operates with no need for extra optimization or asset retrieval; (ii) we introduce a novel feature aggregation module that integrates local and global scene information from visual and geometric encoders within the feature extraction module. Coupled with a position head, this enables the generation of 3D assets and their relative spatial positions in a single feedforward pass; (iii) we demonstrate SceneGen's direct extensibility to multi-image input scenarios. Despite being trained solely on single-image inputs, our architecture yields improved generation performance when multiple images are provided; and (iv) extensive quantitative and qualitative evaluations confirm the efficiency and robustness of our approach. We believe this paradigm offers a novel solution for high-quality 3D content generation, potentially advancing its practical applications in downstream tasks. The code and model will be publicly available at: https://mengmouxu.github.io/SceneGen.

cs.CV↗

arXiv2025

One-Step Diffusion Transformer for Controllable Real-World Image Super-Resolution

Recent advances in diffusion-based real-world image super-resolution (Real-ISR) have demonstrated remarkable perceptual quality, yet the balance between fidelity and controllability remains a problem: multi-step diffusion-based methods suffer from generative diversity and randomness, resulting in low fidelity, while one-step methods lose control flexibility due to fidelity-specific finetuning. In this paper, we present ODTSR, a one-step diffusion transformer based on Qwen-Image that performs Real-ISR considering fidelity and controllability simultaneously: a newly introduced visual stream receives low-quality images (LQ) with adjustable noise (Control Noise), and the original visual stream receives LQs with consistent noise (Prior Noise), forming the Noise-hybrid Visual Stream (NVS) design. ODTSR further employs Fidelity-aware Adversarial Training (FAA) to enhance controllability and achieve one-step inference. Extensive experiments demonstrate that ODTSR not only achieves state-of-the-art (SOTA) performance on generic Real-ISR, but also enables prompt controllability on challenging scenarios such as real-world scene text image super-resolution (STISR) of Chinese characters without training on specific datasets. Codes are available at https://github.com/RedMediaTech/ODTSR.

cs.CV↗

arXiv2025

SaFiRe: Saccade-Fixation Reiteration with Mamba for Referring Image Segmentation

Referring Image Segmentation (RIS) aims to segment the target object in an image given a natural language expression. While recent methods leverage pre-trained vision backbones and more training corpus to achieve impressive results, they predominantly focus on simple expressions--short, clear noun phrases like "red car" or "left girl". This simplification often reduces RIS to a key word/concept matching problem, limiting the model's ability to handle referential ambiguity in expressions. In this work, we identify two challenging real-world scenarios: object-distracting expressions, which involve multiple entities with contextual cues, and category-implicit expressions, where the object class is not explicitly stated. To address the challenges, we propose a novel framework, SaFiRe, which mimics the human two-phase cognitive process--first forming a global understanding, then refining it through detail-oriented inspection. This is naturally supported by Mamba's scan-then-update property, which aligns with our phased design and enables efficient multi-cycle refinement with linear complexity. We further introduce aRefCOCO, a new benchmark designed to evaluate RIS models under ambiguous referring expressions. Extensive experiments on both standard and proposed datasets demonstrate the superiority of SaFiRe over state-of-the-art baselines.

cs.CV↗

arXiv2025

MedS$^3$: Towards Medical Slow Thinking with Self-Evolved Soft Dual-sided Process Supervision

Medical language models face critical barriers to real-world clinical reasoning applications. However, mainstream efforts, which fall short in task coverage, lack fine-grained supervision for intermediate reasoning steps, and rely on proprietary systems, are still far from a versatile, credible and efficient language model for clinical reasoning usage. To this end, we propose MedS3, a self-evolving framework that imparts robust reasoning capabilities to small, deployable models. Starting with 8,000 curated instances sampled via a curriculum strategy across five medical domains and 16 datasets, we use a small base policy model to conduct Monte Carlo Tree Search (MCTS) for constructing rule-verifiable reasoning trajectories. Self-explored reasoning trajectories ranked by node values are used to bootstrap the policy model via reinforcement fine-tuning and preference learning. Moreover, we introduce a soft dual process reward model that incorporates value dynamics: steps that degrade node value are penalized, enabling fine-grained identification of reasoning errors even when the final answer is correct. Experiments on eleven benchmarks show that MedS3 outperforms the previous state-of-the-art medical model by +6.45 accuracy points and surpasses 32B-scale general-purpose reasoning models by +8.57 points. Additional empirical analysis further demonstrates that MedS3 achieves robust and faithful reasoning behavior.

cs.CL↗

arXiv2025

EHR-R1: A Reasoning-Enhanced Foundational Language Model for Electronic Health Record Analysis

Electronic Health Records (EHRs) contain rich yet complex information, and their automated analysis is critical for clinical decision-making. Despite recent advances of large language models (LLMs) in clinical workflows, their ability to analyze EHRs remains limited due to narrow task coverage and lack of EHR-oriented reasoning capabilities. This paper aims to bridge the gap, specifically, we present EHR-Ins, a large-scale, comprehensive EHR reasoning instruction dataset, comprising 300k high-quality reasoning cases and 4M non-reasoning cases across 42 distinct EHR tasks. Its core innovation is a thinking-graph-driven framework that enables to generate high-quality reasoning data at scale. Based on it, we develop EHR-R1, a series of reasoning-enhanced LLMs with up to 72B parameters tailored for EHR analysis. Through a multi-stage training paradigm, including domain adaptation, reasoning enhancement, and reinforcement learning, EHR-R1 systematically acquires domain knowledge and diverse reasoning capabilities, enabling accurate and robust EHR analysis. Lastly, we introduce EHR-Bench, a new benchmark curated from MIMIC-IV, spanning 42 tasks, to comprehensively assess reasoning and prediction across EHR scenarios. In experiments, we show that the resulting EHR-R1 consistently outperforms state-of-the-art commercial and open-source LLMs (including DeepSeek-V3 and GPT-4o), surpassing GPT-4o by over 30 points on MIMIC-Bench and achieving a 10\% higher zero-shot AUROC on EHRSHOT. Collectively, EHR-Ins, EHR-R1, and EHR-Bench have significantly advanced the development for more reliable and clinically relevant EHR analysis.

cs.CL↗

arXiv2025

Rethinking Whole-Body CT Image Interpretation: An Abnormality-Centric Approach

Automated interpretation of CT images-particularly localizing and describing abnormal findings across multi-plane and whole-body scans-remains a significant challenge in clinical radiology. This work aims to address this challenge through four key contributions: (i) On taxonomy, we collaborate with senior radiologists to propose a comprehensive hierarchical classification system, with 404 representative abnormal findings across all body regions; (ii) On data, we contribute a dataset containing over 14.5K CT images from multiple planes and all human body regions, and meticulously provide grounding annotations for over 19K abnormalities, each linked to the detailed description and cast into the taxonomy; (iii) On model development, we propose OmniAbnorm-CT, which can automatically ground and describe abnormal findings on multi-plane and whole-body CT images based on text queries, while also allowing flexible interaction through visual prompts; (iv) On evaluation, we establish three representative tasks based on real clinical scenarios, and introduce a clinically grounded metric to assess abnormality descriptions. Through extensive experiments, we show that OmniAbnorm-CT can significantly outperform existing methods in both internal and external validations, and across all the tasks.

eess.IV↗

arXiv2025

Multi-Scale Target-Aware Representation Learning for Fundus Image Enhancement

High-quality fundus images provide essential anatomical information for clinical screening and ophthalmic disease diagnosis. Yet, due to hardware limitations, operational variability, and patient compliance, fundus images often suffer from low resolution and signal-to-noise ratio. Recent years have witnessed promising progress in fundus image enhancement. However, existing works usually focus on restoring structural details or global characteristics of fundus images, lacking a unified image enhancement framework to recover comprehensive multi-scale information. Moreover, few methods pinpoint the target of image enhancement, e.g., lesions, which is crucial for medical image-based diagnosis. To address these challenges, we propose a multi-scale target-aware representation learning framework (MTRL-FIE) for efficient fundus image enhancement. Specifically, we propose a multi-scale feature encoder (MFE) that employs wavelet decomposition to embed both low-frequency structural information and high-frequency details. Next, we design a structure-preserving hierarchical decoder (SHD) to fuse multi-scale feature embeddings for real fundus image restoration. SHD integrates hierarchical fusion and group attention mechanisms to achieve adaptive feature fusion while retaining local structural smoothness. Meanwhile, a target-aware feature aggregation (TFA) module is used to enhance pathological regions and reduce artifacts. Experimental results on multiple fundus image datasets demonstrate the effectiveness and generalizability of MTRL-FIE for fundus image enhancement. Compared to state-of-the-art methods, MTRL-FIE achieves superior enhancement performance with a more lightweight architecture. Furthermore, our approach generalizes to other ophthalmic image processing tasks without supervised fine-tuning, highlighting its potential for clinical applications.

eess.IV↗

arXiv2025

Learning to Instruct for Visual Instruction Tuning

We propose L2T, an advancement of visual instruction tuning (VIT). While VIT equips Multimodal LLMs (MLLMs) with promising multimodal capabilities, the current design choices for VIT often result in overfitting and shortcut learning, potentially degrading performance. This gap arises from an overemphasis on instruction-following abilities, while neglecting the proactive understanding of visual information. Inspired by this, L2T adopts a simple yet effective approach by incorporating the loss function into both the instruction and response sequences. It seamlessly expands the training data, and regularizes the MLLMs from overly relying on language priors. Based on this merit, L2T achieves a significant relative improvement of up to 9% on comprehensive multimodal benchmarks, requiring no additional training data and incurring negligible computational overhead. Surprisingly, L2T attains exceptional fundamental visual capabilities, yielding up to an 18% improvement in captioning performance, while simultaneously alleviating hallucination in MLLMs. Github code: https://github.com/Feng-Hong/L2T.

cs.CV↗

arXiv2025

Dual-granularity Sinkhorn Distillation for Enhanced Learning from Long-tailed Noisy Data

Real-world datasets for deep learning frequently suffer from the co-occurring challenges of class imbalance and label noise, hindering model performance. While methods exist for each issue, effectively combining them is non-trivial, as distinguishing genuine tail samples from noisy data proves difficult, often leading to conflicting optimization strategies. This paper presents a novel perspective: instead of primarily developing new complex techniques from scratch, we explore synergistically leveraging well-established, individually 'weak' auxiliary models - specialized for tackling either class imbalance or label noise but not both. This view is motivated by the insight that class imbalance (a distributional-level concern) and label noise (a sample-level concern) operate at different granularities, suggesting that robustness mechanisms for each can in principle offer complementary strengths without conflict. We propose Dual-granularity Sinkhorn Distillation (D-SINK), a novel framework that enhances dual robustness by distilling and integrating complementary insights from such 'weak', single-purpose auxiliary models. Specifically, D-SINK uses an optimal transport-optimized surrogate label allocation to align the target model's sample-level predictions with a noise-robust auxiliary and its class distributions with an imbalance-robust one. Extensive experiments on benchmark datasets demonstrate that D-SINK significantly improves robustness and achieves strong empirical performance in learning from long-tailed noisy data.

cs.LG↗

arXiv2025

Wide-In, Narrow-Out: Revokable Decoding for Efficient and Effective DLLMs

Diffusion Large Language Models (DLLMs) have emerged as a compelling alternative to Autoregressive models, designed for fast parallel generation. However, existing DLLMs are plagued by a severe quality-speed trade-off, where faster parallel decoding leads to significant performance degradation. We attribute this to the irreversibility of standard decoding in DLLMs, which is easily polarized into the wrong decoding direction along with early error context accumulation. To resolve this, we introduce Wide-In, Narrow-Out (WINO), a training-free decoding algorithm that enables revokable decoding in DLLMs. WINO employs a parallel draft-and-verify mechanism, aggressively drafting multiple tokens while simultaneously using the model's bidirectional context to verify and re-mask suspicious ones for refinement. Verified in open-source DLLMs like LLaDA and MMaDA, WINO is shown to decisively improve the quality-speed trade-off. For instance, on the GSM8K math benchmark, it accelerates inference by 6$\times$ while improving accuracy by 2.58%; on Flickr30K captioning, it achieves a 10$\times$ speedup with higher performance. More comprehensive experiments are conducted to demonstrate the superiority and provide an in-depth understanding of WINO.

cs.CL↗

arXiv2025

CoPAD : Multi-source Trajectory Fusion and Cooperative Trajectory Prediction with Anchor-oriented Decoder in V2X Scenarios

Recently, data-driven trajectory prediction methods have achieved remarkable results, significantly advancing the development of autonomous driving. However, the instability of single-vehicle perception introduces certain limitations to trajectory prediction. In this paper, a novel lightweight framework for cooperative trajectory prediction, CoPAD, is proposed. This framework incorporates a fusion module based on the Hungarian algorithm and Kalman filtering, along with the Past Time Attention (PTA) module, mode attention module and anchor-oriented decoder (AoD). It effectively performs early fusion on multi-source trajectory data from vehicles and road infrastructure, enabling the trajectories with high completeness and accuracy. The PTA module can efficiently capture potential interaction information among historical trajectories, and the mode attention module is proposed to enrich the diversity of predictions. Additionally, the decoder based on sparse anchors is designed to generate the final complete trajectories. Extensive experiments show that CoPAD achieves the state-of-the-art performance on the DAIR-V2X-Seq dataset, validating the effectiveness of the model in cooperative trajectory prediction in V2X scenarios.

cs.CV↗