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Yi Guo

Publications and source records attributed to Yi Guo.

At least 19 recordsLinked to original sources

X-World 1.6: Building Controllable Virtual Cities with World Models

Deploying generative world models for end-to-end closed-loop evaluation and policy learning requires precise scenario control, consistent observations, and sustained generation quality during extended interactions. This report presents \emph{X-World~1.6}, advancing X-World~1.0 toward a more reliable and versatile driving simulator. The upgraded base model offers finer-grained control over traffic semantics, including traffic lights and road markings, together with improved spatial consistency across cameras. Virtual City capabilities broaden scenario construction through a family of models conditioned on diverse 2D and 3D references, including support for generating multi-camera future videos from a single image. An enhanced post-training framework enables efficient causal, few-step generation with stronger temporal coherence, better quality retention over longer rollouts, and improved alignment with human preferences. We also introduce a dedicated evaluation suite to support systematic assessment and guide model iteration. Together, these upgrades expand the scenarios X-World can simulate and improve the efficiency and reliability of its generated observations, supporting broader use in autonomous-driving development.

cs.AI↗

Exploring Post-Training Alignment of Small Language Models for Biomedical Data-to-Text Generation: A Case Study of Medication Leaflet

Translating structured biomedical information into accurate, patient-friendly narratives remains a challenging biomedical data-to-text (D2T) task. While small language models (SLMs) are attractive for healthcare applications because of their lower computational cost, easier deployment, and improved data governance, the impact of post-training alignment on biomedical D2T generation has not been systematically studied. In this work, we compare four alignment methods: supervised fine-tuning (SFT), direct preference optimization (DPO), odds ratio preference optimization (ORPO), and group relative policy optimization (GRPO), using Qwen-2.5 models for medication leaflet generation. We further introduce FDALeaflets, a dataset derived from OpenFDA drug labels, to evaluate cross-regulatory generalization in a zero-shot setting. Selected aligned SLMs outperform GPT-5 on several reference-based metrics, whereas GPT-5 achieves better hallucination and adequacy scores on FDALeaflets under LLM-as-judge evaluation. Among RL-free alignment methods, ORPO achieves the best in-domain semantic performance, reaching a semantic textual similarity (STS) score of 0.9752. GRPO achieves the highest FDALeaflets STS (0.9407), exceeding GPT-5 (0.9295). These findings show that post-training alignment is a key factor in improving both semantic fidelity and generalization for biomedical D2T generation, while clinical safety and patient readability require human verification.

cs.CL↗

Exploring Recurrent-Depth Language Models for Multitask Clinical Text Processing

Clinical natural language processing includes diverse tasks such as information extraction, classification, and question answering. Developing one model for all tasks could simplify deployment and improve knowledge transfer. We evaluated whether small recurrent-depth language models can meet this need through joint fine-tuning and compared their performance with standard transformers. We fine-tuned Ouro1.4B-Thinking, Ouro-2.6B-Thinking, HRM-Text-1B, Qwen3-1.7B, and Qwen3-8B on 9 datasets covering information extraction, classification, inference, and question answering, and evaluated them on four additional datasets excluded from training. Across these 13 datasets, Ouro-1.4B-Thinking achieved higher performances than Qwen3-1.7B on 11 datasets; Ouro-2.6BThinking was competitive with Qwen3-8B on most tasks. Ouro models showed the largest gains on inference and question answering, whereas HRM-Text-1B showed mixed results. These findings support further study of recurrent-depth models for clinical tasks through controlled experiments to isolate architectural effects and investigate how recurrent computation influences reasoning, knowledge acquisition, and generalization.

cs.CL↗

Multilingual Brain Decoding Reveals Shared Cortical Semantic Geometry

Human languages differ markedly in lexical and syntactic form yet can convey similar semantic content. The neural basis of this cross-language semantic commonality remains unclear. Here we developed a multilingual brain decoding framework and analysed brain recordings from 227 participants spanning Chinese, English and French. We found that cortical semantic representations exhibited consistent semantic geometry relationships across languages and individuals, revealing a shared cortical semantic geometry. Importantly, the cross-language consistency of cortical semantic geometry increased from sensorimotor to higher-order association cortex, forming a shared semantic geometry gradient closely aligned with the principal cortical functional gradient. Our work establishes generalizable multilingual brain decoding and identifies stable cortical semantic geometry as a neural basis for semantic commonality across languages.

q-bio.NC↗

Understanding Verification Vulnerabilities in Cross-chain Bridges: An Empirical Study

With the rapid development of blockchain technology, numerous heterogeneous blockchains have emerged, each featuring distinct architectures, consensus mechanisms, and application ecosystems. Cross-chain bridges have consequently become a critical infrastructure component, typically relying on smart contracts to facilitate message passing and asset transfers across heterogeneous blockchains. Unlike single-chain contracts, bridge contracts introduce additional verification logic to validate external-chain data, such as state proofs, message sender identities, and signatures. However, correctly implementing such logic is challenging. We refer to vulnerabilities that violate the security guarantees of cross-chain verification as Cross-chain Verification Vulnerabilities (CVVs). To characterize CVVs, we conduct the first systematic empirical study of this vulnerability class. By analyzing 588 security audit reports from 36 real-world cross-chain bridge projects, we derive 11 CVV patterns and organize them into 5 high-level categories according to the affected verification properties. Following this taxonomy, we construct a CVV dataset containing 830 vulnerability instances across 786 contract files. The dataset establishes mappings among audit reports, audited source-code versions, affected source files, and CVV-pattern labels. We then assess existing detection approaches. Current tools provide limited documented coverage of CVV patterns, while only two of four evaluated LLMs outperform an all-pattern constant baseline of 29.3% Macro-F1; the best reaches 51.2%. Together, the limited tool coverage and inconsistent LLM gains motivate detection methods tailored to cross-chain verification semantics.

cs.CR↗

Neural Decoding as Cognitive Inference

The brain maintains stable cognition despite continuously changing neural activity. How to extract stable cognitive states from variable neural observations remains a central problem in neural decoding. Existing neural decoding methods map neural observations to predefined external labels based on the stimulus-response principle, often capturing recording-specific spurious correlations. Inspired by how the brain infers the world, and specifically by Bayesian brain theory, we recast neural decoding as cognitive inference constrained by brain-intrinsic priors, yielding high-level meta-neural semantic representations. In decoding experiments spanning five neural recording modalities and three cognitive domains (motor, perception and internal mentation), our cognitive inference method reorganized the geometry of neural observation representations, yielding meta-neural semantic representations that exhibited consistent geometric relationships across cognitive tasks and enabled the recovery of stable cognitive states from variable neural observations. Our work provides an account of how the brain maintains relatively stable cognition despite continual changes in the external environment. Cognitive stability is sustained through cognitive inference from changing neural activity, without requiring fixed neural activity patterns.

q-bio.NC↗

A fixed-time stable limit theorem for non-normalized functionals on irregular time grids

Let an Itô semimartingale be observed at times satisfying $τ_{i+1}^n-τ_i^n=(nθ_{τ_i^n})^{-1}$, where $θ$ is adapted and càdlàg, and $θ$ and its reciprocal are bounded on compact intervals. Under the usual hypothesis (H) on the semimartingale, we prove fixed-time stable convergence for test functions whose Hessian is $o(\norm{x})$ at zero. The limit is a sum of jump contributions with sampling scale $θ_{T-}^{-1}$ and separate pre-jump and post-jump volatilities. The proof establishes joint stable convergence of the local Poisson positions and Brownian increments on the endogenous grid, and controls infinitely many small jumps by a uniform Itô estimate. Three examples identify the left-limit sampling scale and show why positivity and càdlàg regularity alone cannot replace local control of the reciprocal sampling intensity.

math.PR↗

A note on estimation of quarticity based on spot volatility

We study an estimator of twice the integrated quarticity of a continuous Itô semimartingale, constructed from squared returns and local estimates of spot volatility. For a shrinking estimation window, we establish a functional stable central limit theorem for a bias-corrected version of the estimator. The limiting conditional variance is $56\int_0^t c_s^4\dd s$, where $c$ denotes spot variance. The proof identifies a common martingale approximation for the three components of the estimator and determines their joint covariance structure. The volatility process may have jumps. We also compare the limiting variance with those of the realized-quarticity and quadratic spot-volatility estimators.

math.ST↗

Win-Ratio Regression for Prioritized Composite Outcomes in Observational Studies: Doubly Robust and Efficient Estimation with Future-Score Correction

Prioritized pairwise outcomes are useful when clinical events follow a natural hierarchy, but censoring before pair resolution complicates estimation. We develop a win-ratio regression framework for this setting by defining a complete-data target over follow-up and deriving an estimating equation for the observed data. The central idea is future-score correction (FC): when censoring prevents later pairwise comparisons from being observed, the method replaces the remaining score with its conditional expectation given the observed history. This correction recovers pairwise information beyond that provided by inverse censoring weights alone. Additionally, we incorporate treatment weighting and baseline outcome augmentation to address baseline confounding. Together, these components yield double robustness for treatment assignment and censoring. Inference is obtained from U-statistic theory. Under standard regularity conditions, the AIPW-FC estimator is asymptotically normal and efficient when all nuisance functions are correctly specified. Simulations with 30%, 50%, and 65% censoring show that efficiency gains from future-score correction increase with the censoring rate, with relative efficiency reaching 1.50 under 65% censoring and near-nominal coverage for AIPW-FC. An application to OneFlorida electronic health record data illustrates the method for a composite outcome that prioritizes death over hospitalization.

stat.ME↗

Learning efficient representations of complex constraints for scalable optimization

Complex constraints often make real-world optimization computationally prohibitive at the scale and speed required for operational decision-making. Here we introduce PolyFormer, a PIML framework that learns compact polytopic representations of the geometry induced by complex constraints. PolyFormer captures constraint-induced geometry and transforms it into efficient polytopic reformulations, reducing the complexity of downstream optimization and enabling the use of off-the-shelf solvers. Neural parameterizations further enable rapid adaptation to varying operating conditions without retraining. Through evaluations across three important problems, i.e., large-scale resource aggregation, network-constrained optimization, and optimization under uncertainty, PolyFormer achieves online solver speedups of up to 6,400-fold and memory reductions of up to 99.87%, while maintaining small feasibility and objective errors. Together, these results establish learned geometric constraint representations as an effective and scalable route to prescriptive optimization under diverse forms of constraint complexity.

cs.LG↗

Distributed AC Optimal Power Flow: A Scalable Solution for Large-Scale Problems

This paper introduces a novel distributed optimization framework for large-scale AC Optimal Power Flow (OPF) problems, offering both theoretical convergence guarantees and rapid convergence in practice. By integrating smoothing techniques and the Schur complement, the proposed approach addresses the scalability challenges and reduces communication overhead in distributed AC OPF. Additionally, optimal network decomposition enables efficient parallel processing under the single program multiple data (SPMD) paradigm. Extensive simulations on large-scale benchmarks across various operating scenarios indicate that the proposed framework outperforms the state-of-the-art centralized solver IPOPT on modest hardware. This paves the way for more scalable and efficient distributed optimization in future power system applications.

math.OC↗

Prosumer Synchronisation Risk: Impacts of Time-Varying Tariffs on Distribution Network Expansion

The rapid deployment of distributed energy resources, including heat pumps, electric vehicles, photovoltaics, and battery storage, is reshaping the operation of low-voltage networks. While distribution system operators often aim to develop time-varying tariffs to incentivise network-friendly behaviour and defer reinforcements, they risk triggering prosumer synchronisation. As prosumers follow price signals, their behaviour may synchronise, avoiding existing load peaks while creating undesirable peaks at other times. This paper quantifies the impact on low-voltage network reinforcement needs when shifting from flat tariffs to two time-varying tariffs: Time-of-Use and Real-Time Pricing. Applying a mixed-integer linear model across 471 low-voltage reference networks in Switzerland, we evaluate expansion requirements under projections of distributed energy resource deployment for 2050. In the model, prosumers operate their distributed energy resources in accordance with their subscribed electricity tariff to minimise costs, and the distribution system operator subsequently optimises reinforcements. Our results demonstrate that while adopting time-varying tariffs can reduce reinforcement investment costs by more than 50%, high adoption rates can reverse this declining trend. Specifically, once prosumer adoption exceeds the optimal thresholds of 50% for Time-of-Use and 40% for Real-Time Pricing, reinforcement needs increase by 39% and 134%, respectively, for an additional 20% of tariff adoption.

eess.SY↗

CARD: Calibration via Agreement in Reverse Diffusion for Out-of-Domain MRI Segmentation

Probability calibration aligns model confidence with predictive accuracy, enabling clinicians to identify unreliable segmentation regions. This alignment breaks down under domain shift, where artifacts and unseen protocols produce confident errors. Existing post-hoc methods adapt the correction at test time, conditioning on predictive entropy, the logit pattern, or augmentation response, but each proxy is read from the terminal prediction, the very quantity that shift corrupts. This motivates reliability evidence beyond the terminal prediction, which categorical diffusion provides in two ways. First, a generative shape prior keeps a capacity-limited reference intact when appearance is corrupted, so its disagreement with the primary segmentor highlights primary-model errors. Second, every reverse step yields a class distribution, separating persistent disagreement from transient discrepancy. Aggregated over the trajectory, this disagreement correlates with Dice at 0.788, against 0.521 for a matched discriminative control. We therefore propose CARD (Calibration via Agreement in Reverse Diffusion), which maps the temporal aggregate of this disagreement to a temperature field applied per pixel across all classes, so that confidence changes while the segmentation does not. Across cardiac, prostate and brain MRI shifts, CARD lowers calibration error in 45 of 49 comparisons against the strongest baseline in each setting.

cs.CV↗

SkillGate: Training In-Policy Skill Selection in Long-Horizon Agents

Agent frameworks increasingly package procedural knowledge as skills: instruction files an agent reads on demand, while public libraries now hold thousands of them. Which skill to read has thus become a decision the policy itself makes in the middle of an episode, yet no existing signal trains it. We show that the default remedy, outcome-rewarded RL over the candidate slate, cannot teach it, for a structural reason we identify and name selector credit starvation: under a broadcast, sequence-level advantage, the few tokens that name the chosen skill carry a vanishing share of the loss, and the credit they inherit is increasingly wrong-signed as trajectories lengthen. A correct choice is punished whenever the execution after it fails, even though the choice itself is among the most valuable decisions in the trajectory. Auditing a completed run's own training artifacts confirms all three properties, each worsening monotonically with horizon. SkillGate removes the failure by construction: it partitions the token support into two disjoint credit channels, outcome credit reaching only execution tokens, and a separate action-local advantage reaching exactly the skill-naming tokens, positive only when a trajectory's single read is the correct one. On five agentic benchmarks under a 16-candidate slate, SkillGate lifts a 9B policy from 40.8% to 53.2% trial success, well ahead of the identical budget spent on outcome reward alone, while cutting exposure to misleading candidates by two thirds and reading fewer skills.

cs.AI↗

Exposition on over-squashing problem on GNNs: Current Methods, Benchmarks and Challenges

Graph-based message-passing neural networks (MPNNs) have achieved remarkable success in both node and graph-level learning tasks. However, several identified problems, including over-smoothing (OSM), limited expressive power, and over-squashing (OSQ), still limit the performance of MPNNs. In particular, OSQ serves as the latest identified problem, where MPNNs gradually lose their learning accuracy when long-range dependencies between graph nodes are required. In this work, we provide an exposition on the OSQ problem by summarizing different formulations of OSQ from current literature, as well as the three different categories of approaches for addressing the OSQ problem. In addition, we also discuss the alignment between OSQ and expressive power and the trade-off between OSQ and OSM. Furthermore, we summarize the empirical methods leveraged from existing works to verify the efficiency of OSQ mitigation approaches, with illustrations of their computational complexities. Lastly, we list some open questions that are of interest for further exploration of the OSQ problem along with potential directions from the best of our knowledge.

cs.LG↗

Bootstrapping Vision-Language Model for Hysteroscopic Surgical Scene Segmentation

Hysteroscopic surgical scene segmentation plays a pivotal role in understanding the hysteroscopic intraoperative environment as well as computer-assisted intervention. However, this task presents unique challenges due to the high morphological similarity among different lesions and the presence of artifacts such as specular reflections, motion blur, and fluid occlusions in surgical videos. In this work, we propose the first vision-language model (VLM)-based hysteroscopic surgical scene segmentation method, which performs pixel-wise localization for fifteen representative categories in hysteroscopic surgical scenes. Our VLM-hyster has a segmentation backbone that utilizes the pretrained image encoder for robust visual feature extraction, coupled with a transformer-based decoder for dense prediction. Moreover, we design category-specific text prompts and incorporate a masked distillation branch to filter out visual features with low correlation to the text prompts, enabling the model to focus more effectively on category-specific image regions and thereby enhancing segmentation performance. We collect a large multicentric hysteroscopic surgical scene dataset, containing 4,020 high-resolution images with detailed mask annotations, for model training and evaluation. Experimental results demonstrate that VLM-hyster substantially outperforms state-of-the-art AI models. Furthermore, extensive assessments by gynecologists, as well as multicentre and prospective validations, demonstrate VLM-hyster's robustness and generalizability. The results suggest that VLM-hyster earns considerable potential in enabling AI-assisted localization of surgical instruments and lesions in hysteroscopic surgeries. Code is available at https://github.com/viscom-tongji/VLM-hyster.

cs.CV↗

An Agentic Generative Large Language Model for Treatment Planning of Colorectal Cancer

Treatment planning in precision oncology requires synthesizing heterogeneous patient information with rapidly evolving clinical guidelines to ensure guideline-concordant care. While large language models (LLMs) show promise in many diagnostic tasks, their adoption for high-stakes treatment planning is hindered by complex reasoning, adherence to timely clinical guidelines, and safety concerns. In this study, we present GatorOnco, an agentic LLM for colorectal cancer (CRC) treatment planning. GatorOnco is developed using a total of 282 billion tokens of biomedical text, including healthcare system-scale clinical text comprising 166 billion tokens from UF Health. We implemented a domain-adaptation method that integrates pre-training, model merging, a two-stage post-training approach, and agent-based reinforcement learning. An agentic retrieval-augmented generation (RAG) approach dynamically integrates time-sensitive clinical guidelines into the reasoning process. In a blind, randomized clinical evaluation conducted by five UF Health oncologists, GatorOnco significantly outperformed open-source LLMs (P < 0.01) and achieved expert-level performance comparable to UF Health oncologists. Compared with expert oncologists, GatorOnco received significantly higher ratings for readability (4.46 vs. 4.19, P < 0.01) and completeness (3.91 vs. 3.52, P < 0.01), while showing statistically comparable performance in correctness (4.09 vs. 4.11, P = 0.921), currency (4.04 vs. 3.98, P = 0.478), and safety (4.22 vs. 4.22, P = 0.999). These findings demonstrate that integrating agentic reasoning with large-scale domain adaptation can help bridge the gap for generative AI in high-stakes cancer treatment planning.

cs.CL↗

Complexity and Stability of Neural Activity Across Aging and Neurodegenerative Disease

Objective: EEG signals fluctuate continuously even within a fixed cognitive state, but an important question is whether the brain still reuses similar activity patterns to represent information over time. Methods: To address this, we model EEG as distributions of windowed activity patterns and quantify their temporal stability using Wasserstein distance, while intrinsic dimensionality captures representational complexity. Results: Across multi-task, lifespan, and clinical EEG datasets, we find that neural representations show constrained, condition-specific stability rather than unconstrained drift. Higher intrinsic dimensionality is consistently associated with lower stability, suggesting that richer representational spaces are less reproducible over time. Both measures exhibit reproducible spatial organization, with posterior regions showing higher dimensionality and lower stability than frontal regions. Healthy aging is characterized by increased dimensionality and reduced stability, whereas mild cognitive impairment and Alzheimer's disease show a joint collapse of both. Conclusions: These findings provide a distribution-level framework for understanding neural stability across cognition, aging, and disease. Significance: This framework offers a principled approach to quantifying neural representational stability, with potential utility as a sensitive biomarker for tracking cognitive aging and neurodegeneration in clinical settings.

q-bio.NC↗