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Zhen Zhang

Publications and source records attributed to Zhen Zhang.

At least 55 records · Page 3Linked to original sources

Nanoscale silicon sensor - guided new insights into early metabolic response of Escherichia coli to ampicillin

Antibiotic killing is often attributed to inhibition of specific cellular targets, yet metabolic processes can strongly influence drug efficacy. However, the relationship between metabolic responses and antibiotic lethality remains incompletely understood. Here, we employed silicon nanowire field-effect transistor (SiNWFET) sensors to monitor real-time metabolic responses of Escherichia coli to ampicillin (AMP). AMP treatment induced a biphasic extracellular pH signature, characterized by rapid acidification followed by alkalization. Metabolomic analyses revealed that the initial acidification resulted from organic acid secretion, whereas the subsequent alkalization was associated with altered amino acid metabolism and formate flux. Using metabolic and respiratory mutants, we found that these extracellular signatures reflected pathway-specific metabolic rewiring that predicted bacterial killing. AMP lethality strongly correlated with ATP dynamics and formate secretion: strains exhibiting larger AMP-induced ATP increases and greater formate secretion showed enhanced susceptibility. In contrast to literature, changes in NADH and NADPH levels did not support redox stress as the primary bacterial-killing mechanism. Together, our findings identify formate metabolism as a key pathway underlying the elevated ATP levels associated with AMP bactericidal activity. These results demonstrate that SiNWFET sensors provide a versatile label-free tool for probing antibiotic mechanisms, rapidly assessing bacterial susceptibility, and potentially guiding antimicrobial therapy development.

physics.ins-det↗

Margin-Drop Coordinates for Cross-Budget Robustness Evaluation

Fixed-budget robustness evaluation can select the wrong frozen vision encoder. An encoder that survives a shallow attack may lose most of that robustness when the same evaluation is strengthened. We ask whether the shallow evaluation contains enough information to identify this budget fragility. For each clean-correct sample, the evaluation records the clean pairwise margin, the first-order linearized margin-drop scale, the margin drop from a clean-start one-step attack, and the drop reached by an iterative attack. Normalizing by that scale gives three margin-drop coordinates capturing clean margin slack, one-step shortfall, and drift, where drift is the additional normalized margin drop the iterative attack reaches beyond the one-step perturbation. Together, they reconstruct the normalized post-attack margin and therefore the pass-or-fail outcome. Across 42 pretrained frozen vision encoders, the shallow survival rate carries essentially no rank information about subsequent PGD-10 to PGD-200 collapse, at Spearman -0.006, while the median shallow drift coordinate ranks the same collapse at +0.811. The result persists in a held-out encoder pool and under an $\ell_\infty$ evaluation. With deep evaluation limited to 11 encoders, ranking by shallow drift recovers 11 of the 17 high-collapse encoders, compared with 5 under survival-rate ranking. The full coordinate decomposition further distinguishes cases that share the same fixed-budget residual but diverge at deeper budgets, and separates margin repair from drift repair under interventions, revealing distinct repair paths that endpoint robustness alone does not identify.

cs.LG↗

Broadband hard X-ray attosecond pulses from extremely chirped electron beams

Attosecond pulses from free-electron lasers have opened the doors to atomic site-specific studies of bound electronic dynamics on their natural, sub-femtosecond timescales. Key to their success has been electron beam shaping techniques enabling the generation of sub-femtosecond current spikes with peak currents on the order of 10 kA. We demonstrate in an RF linac the generation of current spikes with extreme chirps on the order of 350 MeV/micron, directly competitive with the chirps expected from beam-driven plasma wakefield accelerators. Leveraging chirp-taper compensation, we use these highly chirped beams to generate hard X-ray attosecond pulses with bandwidths exceeding 30 eV, a factor of two beyond previous demonstrations. We simultaneously present the first explicit experimental evidence of chirp-taper compensation in an attosecond XFEL, finding that optimal tapering improves the bandwidth and pulse energy by factors of two and five, respectively, for our conditions. In addition to the immediate utility of such broadband hard X-ray pulses, electron beams with such extreme chirps can be utilized for unique new experimental modalities by performing further compression after the undulators. Such post-lasing compression can enable subsequent superradiant light emission at longer wavelengths, or direct excitation of quantum systems with the beam's intense space-charge field for unique attosecond pump-probe possibilities.

physics.acc-ph↗

Cross-View Correspondence Is a Measurement Intervention: Two-Sided Validation for Agent Evaluation and Credit Assignment

Agent evaluations and trace-based learning often compare outputs across transformed views through a post-response correspondence treated as neutral preprocessing. We show that this correspondence is a measurement intervention: omitting it can manufacture sensitivity, an over-aggressive map can manufacture invariance, and multiple optimal correspondences can leave mechanism labels and signed learning credit unidentified. We develop a validity theory and audit with three components: two-sided validation of nuisance removal and response preservation, all-optima identification of downstream conclusions, and uncertainty propagation after validity is established. We characterize the linear feasibility boundary for response-preserving nuisance removal, compute sharp ranges over exact-optimum correspondence sets, and give a distribution-free certificate that retains a credit coordinate only when all exact optima agree on its nonzero sign. Across public code and SQL pipelines, two deterministic optimal tracebacks disagree on temporal localization for 55.9% of 1,586 nonzero trajectory pairs; two frozen 800-rollout tool-use audits, including a task-and-seed-disjoint replication, expose exact-optimum reversals of intended turn-level credit, although a clean public quick-start subset shows none. A pre-registered transport gate failed on natural responses; frozen corrected and held-out controls then show that a map calibrated only on benign examples erases every retained harmful response, while two-sided validation selects response-preserving alternatives. Cross-view correspondence must therefore be declared, validated, and propagated into uncertainty before agent evaluation or credit assignment supports a point conclusion.

cs.LG↗

CompCPZ: Preserving Multi-Modal Intent in Language-Guided Robot Manipulation

A robot asked to "place the cup near the red plate or the blue plate" may reach the centroid between them and appear geometrically successful, while satisfying neither disjunct of the instruction. This silent semantic failure exposes a structural limitation of language-conditioned robot policies: representations that collapse a disjunctive instruction into a single connected set cannot preserve all feasible modes, and planners that commit to one action degrade under run-time mode uncertainty. We address this limitation with CompCPZ, a sound algebraic layer that language-conditioned learning systems wrap to recover multi-modal disjunctive representation, recursively composing per-primitive constrained polynomial zonotope enclosures along the language parse tree with distribution-free conformal coverage and sub-millisecond runtime. On a closed-loop ManiSkill3 tabletop-manipulation benchmark, CompCPZ outperforms convex set baselines, multi-peak decoders, and a zero-shot vision-language-action model (1,900/1,918 paired wins, p << 10^(-30)); the same compiler also transfers without retuning to planar real-robot trials on a Unitree Go2 quadruped under motion capture. These results suggest that compositional language grounding should be evaluated not only by reaching a decoded target, but by whether the represented feasibility set preserves the connected-component structure of the user's intent.

cs.RO↗

Electromagnetic World Model for 6G: A Unified Framework for Joint Environment Reconstruction and Channel Prediction

The integration of sensing, communication, and intelligence is becoming a key enabler for sixth generation (6G) wireless systems, where intelligent terminals are expected to simultaneously support efficient link establishment and reliable environmental sensing. However, existing studies mainly exploit sensing information or communication information to address a single task, such as channel prediction or environment reconstruction. Motivated by the shared dependence of optical and radio-frequency signals on the surrounding environment, we propose the electromagnetic world model (EMWM), the first unified framework for joint environment reconstruction and channel prediction. EMWM learns a common electromagnetic representation with the potential to provide a modeling foundation for 6G tasks. Specifically, partial channel state information (CSI) and multi-view red-green-blue (RGB) images are encoded into CSI and visual tokens and jointly processed by a hierarchical world-model backbone with local and global aggregation. Based on the learned representation, a mixture-of-experts (MoE)-based CSI prediction head reconstructs the complete CSI, while a depth prediction head estimates multi-view depth maps that are further converted into three-dimensional (3D) point clouds. Moreover, a large-scale multi-modal dataset is constructed based on a campus digital twin. Experimental results show that EMWM outperforms conventional neural network and large language model (LLM) baselines in both CSI prediction and environment reconstruction, achieving a squared generalized cosine similarity (SGCS) of 0.9699 for CSI prediction while demonstrating robustness across different signal-to-noise ratio (SNR) conditions and zero-shot generalization at 28 GHz.

eess.SP↗

Certified Mechanistic Interpretability: Lifting Single-Input Findings to Bounded Neighbourhoods

Mechanistic interpretability reverse-engineers transformer circuits one input at a time, leaving observed mechanisms without guarantees over bounded input neighbourhoods. We address this gap with a framework based on constrained polynomial-zonotope (CPZ) propagation that lifts mechanistic-interpretability observations from a single input to certified statements over a bounded set of perturbations. Three internal-attention queries (top-$k$ stability, evidence mass, and attention entropy) are formulated as tractable programs over the simplex of attention weights, and CPZ propagation through transformer blocks is shown to preserve the softmax simplex and the LayerNorm zero-mean identity exactly. A recursive Jacobian zonotope construction extends the same certificates across layer depth by linearising the block stack at the input and avoids per-layer generator growth. We instantiate the framework on transformer attention; the resulting certificates offer a way to sharpen mechanistic statements that single-input inspection cannot resolve on its own, and to inform downstream decisions in regimes where empirical heuristics may be misleading.

cs.LG↗

Differentiable Fuzzy Inference Layer: A Monotone, Compositional Ordinal Reasoning Head for Large Language Models

A state-of-the-art language model asked to interpret "most of most students passed" typically answers "most," though composing two instances of "most" yields a proportion closer to "some." We trace this failure to an architectural choice rather than a data deficit: standard classifier heads treat ordinal categories as independent labels, with no mechanism to respect their natural ordering or compose them algebraically. We introduce the Differentiable Fuzzy Inference Layer (DFIL), a dual-path prediction head pairing a standard classifier with a scalar-bottlenecked branch grounded in a bank of ordered membership functions. DFIL supplies two structural primitives that a label-only head cannot inherit: monotonicity in the underlying quantity, and compositional reasoning via t-norm operations without any compositional training data. The scalar branch additionally provides an interpretable interface for analyzing residual errors. We instantiate DFIL on ordinal natural-language tasks across diverse LLM families.

cs.CL↗

The Cost of Conservation: Coordination-Memory Laws for Exact-Support Generation

Many AI systems make decisions locally, even when every realized output must obey an additive conservation law, such as selecting exactly a fixed number of items. This constraint can be statistically invisible: small subsets of a balanced fixed-budget output look increasingly independent, yet communication-free coordinate-parallel generation needs exponentially many pre-shared plans, while a sequential exact sampler needs only logarithmic memory. We study product measures conditioned on additive conservation laws in the intermediate regime where one plan is selected before a fixed-order pass, every plan is a bounded-state stochastic executor whose support is entirely legal, and the mixture of plan laws approximates the target distribution in total variation. Our main result identifies the optimal asymptotic selector rate, up to constant factors, with the killed spectral profile of the conservation-difference walk. The resulting coordination cost decreases as an inverse power of live-state width, with an exponent determined by intrinsic conservation rank rather than alphabet size; the law extends to noncentral budgets and heterogeneous local scores. The converse is driven by a state-versus-resource-sum obstruction, while a rate-matching construction compiles discrepancy control into exact-support finite-state plans. Complementary results characterize block-parallel plan complexity and the benefit of programmable output order. Together, these results show precisely how online memory substitutes for front-loaded coordination in exact-support generation.

cs.AI↗

MathGen: Revealing the Illusion of Mathematical Competence through Text-to-Image Generation

Modern generative models have demonstrated the ability to solve challenging mathematical problems. In many real-world settings, however, mathematical solutions must be expressed visually through diagrams, plots, geometric constructions, and structured symbolic layouts, where correctness depends on precise visual composition. This naturally raises the question of whether generative models can still do so when the answer must be rendered visually rather than written in text? To study this problem, we introduce MathGen, a rigorous benchmark of 420 problems spanning seven core domains, including 350 Clean-Scene problems and 70 paired Open-Scene problems. Each problem is evaluated under a Script-as-a-Judge protocol with problem-specific verification criteria implemented through reusable executable scripts for deterministic and reproducible evaluation. Experiments on representative open-source and proprietary text-to-image models show that mathematical fidelity remains a major bottleneck: even the best closed-source model reaches only 53.7% overall accuracy, while open-source models achieve just 1--11%, often near 0% on structured tasks, particularly those requiring precise geometric and functional rendering. Overall, current T2I models remain far from reliable at even elementary mathematical visual generation.

cs.CV↗

CLAP: Isolating Content from Style through Contrastive Learning with Augmented Prompts

Contrastive vision-language models, such as CLIP, have garnered considerable attention for various downstream tasks, mainly due to the remarkable ability of the learned features for generalization. However, the features they learned often blend content and style information, which somewhat limits their generalization capabilities under distribution shifts. To address this limitation, we adopt a causal generative perspective for multimodal data and propose contrastive learning with data augmentation to disentangle content features from the original representations. To achieve this, we begin with exploring image augmentation techniques and develop a method to seamlessly integrate them into pre-trained CLIP-like models to extract pure content features. Taking a step further, recognizing the inherent semantic richness and logical structure of text data, we explore the use of text augmentation to isolate latent content from style features. This enables CLIP-like model's encoders to concentrate on latent content information, refining the learned representations by pre-trained CLIP-like models. Our extensive experiments across diverse datasets demonstrate significant improvements in zero-shot and few-shot classification tasks, alongside enhanced robustness to various perturbations. These results underscore the effectiveness of our proposed methods in refining vision-language representations and advancing the state-of-the-art in multimodal learning.

cs.CV↗

Probing Variations in Earth's Ionosphere Using Pulsars

We present high cadence 10-minute rotation measure (RM) monitoring of PSR~J0814+7429 using the LOw-Frequency ARray, aiming to probe ionospheric variability along the pulsar line of sight (LoS). By separating the ionospheric contribution from the observed RM, we quantitatively reconstruct the diurnal variation of the ionospheric electron density along the pulsar LoS based on the World Magnetic Model. The derived variations exhibit clear solar-driven modulation, including the ionospheric noontime bite-out phenomenon, and show good agreement with the LoS total electron content reconstructed from independent global vertical total electron content maps. These results demonstrate the feasibility of using pulsars as probes of temporal variations in the electron density of the Earth's ionosphere.

astro-ph.HE↗

Hybrid Probabilistic Zonotopes for Identifiable and Refinable Predictive Uncertainty

Probabilistic prediction heads in neural networks typically output either a Gaussian mixture or a single conformal region. Neither separates the distinct sources of uncertainty often present in real prediction tasks: a discrete choice among modes, bounded systematic drift within the chosen mode, and irreducible stochastic noise. We introduce the Hybrid Probabilistic Zonotope (HProbZ), an output head that represents these three sources as binary, bounded, and stochastic generators of a zonotope, and admits a closed-form likelihood by convolution. Sharing the bounded generator across prediction steps couples future predictions algebraically, so observing one step refines the predictive distribution at every remaining step in a single forward pass. We establish that the three generators are identifiable from the likelihood up to permutation, and that an HProbZ density is representationally distinct from any finite Gaussian mixture. The same shared structure provides analytic per-mode risk and distribution-free multi-modal conformal sets at inference time. Empirical analysis on representative prediction benchmarks supports the effectiveness of the design relative to same-encoder mixture baselines, while offering structural properties that mixture or convex-conformal predictors do not jointly provide.

cs.LG↗

Matrix Zonotopic Attention: A Context-Adaptive Value Projection for Set Transformers

Multi-head attention combines an input-dependent softmax routing with an input-independent linear value projection, so the per-sample operator mapping aggregated values to outputs is the same for every input set. We study the consequences of this asymmetry for permutation-invariant set targets. We introduce the Transformation Degrees of Freedom (TDOF) of a target operator, a complexity measure counting the input-dependent directions an exact representation requires, and present a depth-separation analysis showing that context-rigid attention needs depth proportional to the target's TDOF, whereas a single layer with a context-adaptive value family can represent the same target. Building on this analysis, we propose Matrix Zonotopic Attention (MZAttn), which replaces the fixed value projection with a context-adaptive matrix-zonotope family: a centre matrix plus a sum of generator matrices weighted by input-dependent gates. The construction reduces to standard multi-head attention at initialisation, preserves permutation equivariance, and admits a data-driven reachability interpretation. Experiments on a range of set-prediction tasks are consistent with the TDOF prediction that the architectural advantage is selective: it appears on targets that depend on the input set in a high-rank, sparsely combinatorial way, and is small on aggregate-statistic targets where parameter-matched standard attention is already competitive.

cs.LG↗

Double Parton Scattering Effects on the Measurement of the W-Boson Mass

Double parton scattering (DPS) corresponds to events where two parton-parton scatterings occur in a single hadron-hadron collision. The DPS effects may arise from the spectator scatterings that are somewhat related to semi-hard QCD activities. In this work, we investigate the DPS effects on the W-boson mass measurements. Especially, our analysis reveals that the DPS effects contribute additional missing transverse momenta from spectator scatterings as well as relevant inclusive cross sections, potentially altering the distribution of total missing transverse momenta. Consequently, the DPS effects have the potential to cause an increase in the measured W-boson mass by the CDF detector, which helps to understand the deviation of the CDF-II measurements from other measurements and the predicted value in the Standard Model. This could be further validated in upcoming studies, such as the W-like analyses of the Z boson production, which will potentially open new avenues for probing QCD dynamics in the semi-hard regime.

hep-ph↗

Optimizing Parameterized Physics-Informed Neural Networks to Solve Multilayered Static Linear Elastic PDEs

Designing multilayered materials for controlled deformation is heavily bottlenecked by the immense computational costs and time of traditional, industrial-grade finite element methods (FEM). This excessive expense severely limits design space exploration and gradient-based optimization. To streamline the workflow, we propose a framework for parameterized physics-informed neural networks (P2INNs). The framework encompasses three core components: I. a FEM baseline with a Hex8 element and trilinear basis functions, II. a P2INN displacement field model across variable material stiffness and layer thicknesses, and III. FEM-referenced evaluation. The PINN enforces static linear elasticity via Navier-Cauchy residuals with training strategies that prioritize physics, including layerwise PDE decomposition, interface continuity penalty, and compliance aware scaling. For one-layer, pure physics-driven configurations, the PINN achieves a mean volume MAE of 1.56% and worst-case volume MAE of 2.87% against the FEM benchmark. For three-layer configurations with controlled supervised training, the PINN achieves a mean volume MAE of 2.53% and worst-case volume MAE of 4.66%, meeting the near-5% worst-case volume-MAE target for preliminary design-space exploration. The trained P2INN model remains a lightweight model with a simple forward pass for future calculations, creating an alternative to traditional FEM. By drastically reducing the need for expensive FEM evaluations, this approach could accelerate the inverse design and optimization of advanced layered architectures for protective structures in various load-heavy or potentially collision-heavy fields.

cs.CE↗

Effects of light-cluster degrees of freedom on collective flows in heavy-ion collisions at FOPI energies

Within a lattice Boltzmann-Uehling-Uhlenbeck transport model coupled to a kinetic approach for light-cluster formation, we investigate the impact of explicit light-cluster degrees of freedom on collective flows in Au+Au collisions at FOPI energies with beam energies $E_{\rm beam}$= $120$--$1500 A$ MeV by using a density-, momentum-, and isospin-dependent N$5$LO Skyrme pseudopotential. We first benchmark the kinetic approach by comparing the calculated light-cluster yields with FOPI data in central Au+Au collisions. We then analyze the collective flows of protons and light nuclei (deuterons, tritons, $^{3}\mathrm{He}$, and $^{4}\mathrm{He}$) in mid-central collisions. For protons, calculations with and without dynamical light-cluster degrees of freedom are compared to quantify the influence of dynamical cluster formation on proton directed ($v_1$), elliptic ($v_2$), triangular ($v_3$), and quadrangular ($v_4$) flows. We find that the dynamical light-cluster effect appreciably modifies proton $v_1$--$v_4$ flows at $E_{\rm beam}=120$--$150 A$ MeV, remains visible at $E_{\rm beam}=250$--$400 A$ MeV, and gradually weakens at $E_{\rm beam}\gtrsim 600 A$ MeV. For light nuclei, the kinetic approach captures the overall beam-energy dependence of the FOPI flow data, with better agreement for $E_{\rm beam}\geq 400 A$ MeV. We further examine the nucleon-number scaling of $v_2/A$ in both model calculations and experimental data, finding that the kinetic light-cluster formation approach qualitatively reproduces the observed scaling behavior. These results highlight the importance of a dynamical treatment of light-cluster formation for interpreting collective flows in heavy-ion collisions below about $600 A$ MeV, although the clustering effects on proton flows are minor at higher collision energies.

nucl-th↗

Certifying Plans under Model Mismatch: A Trilemma for Reachability from Scarce Data

Sim-to-real policies are designed under nominal dynamics, but target-system trials may yield only a few isolated one-step transitions. We study pre-execution certification of a fixed control sequence, such as an action chunk produced by a learned policy. If the sequence reaches an unobserved state-input region, the observations remain consistent with target systems whose trajectories separate along it by an arbitrarily large amount. Any deterministic certifier sound for all of them must then decline to certify or return a reachable tube with arbitrarily large projected width. For bounded smooth classes of the target-nominal model error, we derive a finite plan-dependent projected-width lower bound. These results expose a trilemma among uniform trajectory containment, finite projected width, and unrestricted model-error behavior beyond the observations. ForeReach requires a supplied componentwise Lipschitz bound on the model error. Observed transition pairs can refute this declaration but cannot establish it outside the observed locations. Conditional on a valid declaration, our method constructs a set-membership envelope for the model error, propagates a zonotopic reachable tube, and certifies only when propagation remains within the certification domain and every projected tube slice avoids the unsafe set. In two benchmark systems, calibration baselines may remain narrow after losing trajectory containment outside data support, whereas our method declines to certify unsupported sequences and recovers certification when relevant target data and sufficient obstacle clearance are available.

cs.RO↗