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Zongyu Li

Publications and source records attributed to Zongyu Li.

2 recordsLinked to original sources

PUID: A Personalized Deconfounding Framework for Recommender Systems under Hidden Confounding

Recommender systems often rely on observational user-item interaction data, which is prone to selection bias due to users' selective interactions with items. While techniques such as inverse propensity weighting (IPW) and doubly robust estimators are effective in addressing selection bias from observed confounding, they become unreliable when hidden confounding exists, meaning that there are confounders that influence both user clicks and feedback but are not observable (e.g., user salary). Existing approaches relying on randomized controlled trials (RCTs) or global sensitivity bounds are constrained in practice: RCTs demand costly experimental data, while global sensitivity bounds presume a uniformly bounded effect of unmeasured confounders on propensities through sensitivity analysis, thereby neglecting heterogeneity across user-item interactions. To overcome this limitation, we propose a novel framework, Personalized Unobserved-Confounding-aware Interaction Deconfounder (PUID), which estimates user-item level sensitivity bounds, thereby substantially relaxing the homogeneity assumption inherent in global sensitivity bounds. Under mild assumptions, we use an entropy-based method to estimate the individualized strength of hidden confounding. Specifically, if observed user and item features can already well predict the exposure status (i.e., the mutual information is small), then the influence of hidden confounding is assumed to be small. To ensure both robustness and predictive accuracy, we further develop an adversarial optimization strategy and propose a benchmark-guided variant (BPUID) that incorporates pre-trained models as stabilizing references. Extensive experiments on three real-world datasets demonstrate that our approach consistently outperforms state-of-the-art baselines under hidden confounding, without requiring RCT data.

cs.LG

Enhancing brain age estimation with structural MRI and synthesized cerebral blood volume maps

BrainAGE is a promising imaging-derived biomarker of neurobiological ageing and disease risk, yet current approaches rely predominantly on T1-weighted structural MRI, overlooking functional vascular changes that may precede tissue damage and cognitive decline. DeepCBV maps, synthesized from non-contrast MRI, offer a scalable alternative to contrast-enhanced perfusion imaging by capturing vascular information relevant to early neurodegeneration. We developed a multimodal BrainAGE framework that combines predictions from two separate three-dimensional convolutional neural networks: one trained only on structural MRI scans and another trained only on DeepCBV maps. Each model was trained and validated on 2851 scans from 13 open-source datasets and was evaluated for concordance with MCI and AD. The combined model achieved the most accurate brain age gap for CN controls, with a mean absolute error of 3.95 years, outperforming models trained on MRI or DeepCBV alone. Saliency maps revealed complementary modality contributions: MRI emphasized white matter and cortical atrophy, while DeepCBV highlighted vascular-rich and periventricular regions implicated in hypoperfusion and early cerebrovascular dysfunction, consistent with known patterns of normal ageing. Next, we observed that BrainAGE increased stepwise across diagnostic strata (CN < MCI < AD) and correlated with cognitive impairment. DeepCBV-based BrainAGE showed a particularly strong separation between stable versus progressive MCI, suggesting sensitivity to prodromal vascular changes that precede overt atrophy. Integrating structural MRI with deep learning-derived vascular measures substantially enhances BrainAGE estimation and improves sensitivity to MCI and AD progression, supporting its potential role in risk stratification, early detection and monitoring of therapeutic response.

eess.IV