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arXiv2023

Towards Segment Anything Model (SAM) for Medical Image Segmentation: A Survey

Due to the flexibility of prompting, foundation models have become the dominant force in the domains of natural language processing and image generation. With the recent introduction of the Segment Anything Model (SAM), the prompt-driven paradigm has entered the realm of image segmentation, bringing with a range of previously unexplored capabilities. However, it remains unclear whether it can be applicable to medical image segmentation due to the significant differences between natural images and medical images.In this work, we summarize recent efforts to extend the success of SAM to medical image segmentation tasks, including both empirical benchmarking and methodological adaptations, and discuss potential future directions for SAM in medical image segmentation. Although directly applying SAM to medical image segmentation cannot obtain satisfying performance on multi-modal and multi-target medical datasets, many insights are drawn to guide future research to develop foundation models for medical image analysis. To facilitate future research, we maintain an active repository that contains up-to-date paper list and open-source project summary at https://github.com/YichiZhang98/SAM4MIS.

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arXiv2024

TP-UNet: Temporal Prompt Guided UNet for Medical Image Segmentation

The advancement of medical image segmentation techniques has been propelled by the adoption of deep learning techniques, particularly UNet-based approaches, which exploit semantic information to improve the accuracy of segmentations. However, the order of organs in scanned images has been disregarded by current medical image segmentation approaches based on UNet. Furthermore, the inherent network structure of UNet does not provide direct capabilities for integrating temporal information. To efficiently integrate temporal information, we propose TP-UNet that utilizes temporal prompts, encompassing organ-construction relationships, to guide the segmentation UNet model. Specifically, our framework is featured with cross-attention and semantic alignment based on unsupervised contrastive learning to combine temporal prompts and image features effectively. Extensive evaluations on two medical image segmentation datasets demonstrate the state-of-the-art performance of TP-UNet. Our implementation will be open-sourced after acceptance.

cs.CV↗

arXiv2022

Semi-Supervised and Self-Supervised Collaborative Learning for Prostate 3D MR Image Segmentation

Volumetric magnetic resonance (MR) image segmentation plays an important role in many clinical applications. Deep learning (DL) has recently achieved state-of-the-art or even human-level performance on various image segmentation tasks. Nevertheless, manually annotating volumetric MR images for DL model training is labor-exhaustive and time-consuming. In this work, we aim to train a semi-supervised and self-supervised collaborative learning framework for prostate 3D MR image segmentation while using extremely sparse annotations, for which the ground truth annotations are provided for just the central slice of each volumetric MR image. Specifically, semi-supervised learning and self-supervised learning methods are used to generate two independent sets of pseudo labels. These pseudo labels are then fused by Boolean operation to extract a more confident pseudo label set. The images with either manual or network self-generated labels are then employed to train a segmentation model for target volume extraction. Experimental results on a publicly available prostate MR image dataset demonstrate that, while requiring significantly less annotation effort, our framework generates very encouraging segmentation results. The proposed framework is very useful in clinical applications when training data with dense annotations are difficult to obtain.

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arXiv2018

Stacked U-Nets: A No-Frills Approach to Natural Image Segmentation

Many imaging tasks require global information about all pixels in an image. Conventional bottom-up classification networks globalize information by decreasing resolution; features are pooled and downsampled into a single output. But for semantic segmentation and object detection tasks, a network must provide higher-resolution pixel-level outputs. To globalize information while preserving resolution, many researchers propose the inclusion of sophisticated auxiliary blocks, but these come at the cost of a considerable increase in network size and computational cost. This paper proposes stacked u-nets (SUNets), which iteratively combine features from different resolution scales while maintaining resolution. SUNets leverage the information globalization power of u-nets in a deeper network architectures that is capable of handling the complexity of natural images. SUNets perform extremely well on semantic segmentation tasks using a small number of parameters.

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arXiv2025

Multimodal-Aware Fusion Network for Referring Remote Sensing Image Segmentation

Referring remote sensing image segmentation (RRSIS) is a novel visual task in remote sensing images segmentation, which aims to segment objects based on a given text description, with great significance in practical application. Previous studies fuse visual and linguistic modalities by explicit feature interaction, which fail to effectively excavate useful multimodal information from dual-branch encoder. In this letter, we design a multimodal-aware fusion network (MAFN) to achieve fine-grained alignment and fusion between the two modalities. We propose a correlation fusion module (CFM) to enhance multi-scale visual features by introducing adaptively noise in transformer, and integrate cross-modal aware features. In addition, MAFN employs multi-scale refinement convolution (MSRC) to adapt to the various orientations of objects at different scales to boost their representation ability to enhances segmentation accuracy. Extensive experiments have shown that MAFN is significantly more effective than the state of the art on RRSIS-D datasets. The source code is available at https://github.com/Roaxy/MAFN.

cs.CV↗

arXiv2025

HyCTAS: Multi-Objective Hybrid Convolution-Transformer Architecture Search for Real-Time Image Segmentation

Real-time image segmentation demands architectures that preserve fine spatial detail while capturing global context under tight latency and memory budgets. Image segmentation is one of the most fundamental problems in computer vision and has drawn a lot of attention due to its vast applications in image understanding and autonomous driving. However, designing effective and efficient segmentation neural architectures is a labor-intensive process that may require numerous trials by human experts. In this paper, we address the challenge of integrating multi-head self-attention into high-resolution representation CNNs efficiently by leveraging architecture search. Manually replacing convolution layers with multi-head self-attention is non-trivial due to the costly overhead in memory to maintain high resolution. By contrast, we develop a multi-target multi-branch supernet method, which not only fully utilizes the advantages of high-resolution features but also finds the proper location for placing the multi-head self-attention module. Our search algorithm is optimized towards multiple objectives (e.g., latency and mIoU) and is capable of finding architectures on the approximate Pareto front with an arbitrary number of branches in a single search. We further present a series of models via the Hybrid Convolutional-Transformer Architecture Search (HyCTAS) method that searches for the best hybrid combination of lightweight convolution layers and memory-efficient self-attention layers between branches from different resolutions and fuses them at high resolution for both efficiency and effectiveness. On Cityscapes, ADE20K, and COCO, HyCTAS discovers competitive real-time models without ImageNet pretraining, delivering strong accuracy and latency trade-offs. Code and models are available at https://github.com/MarvinYu1995/HyCTAS.

cs.CV↗

arXiv2026

FlowDIS: Language-Guided Dichotomous Image Segmentation with Flow Matching

Accurate image segmentation is essential for modern computer vision applications such as image editing, autonomous driving, and medical image analysis. In recent years, Dichotomous Image Segmentation (DIS) has become a standard task for training and evaluating highly accurate segmentation models. Existing DIS approaches often fail to preserve fine-grained details or fully capture the semantic structure of the foreground. To address these challenges, we present FlowDIS, a novel dichotomous image segmentation method built on the flow matching framework, which learns a time-dependent vector field to transport the image distribution to the corresponding mask distribution, optionally conditioned on a text prompt. Moreover, with our Position-Aware Instance Pairing (PAIP) training strategy, FlowDIS offers strong controllability through text prompts, enabling precise, pixel-level object segmentation. Extensive experiments demonstrate that our method significantly outperforms state-of-the-art approaches both with and without language guidance. Compared with the best prior DIS method, FlowDIS achieves a 5.5% higher $F_β^ω$ measure and 43% lower MAE ($\mathcal{M}$) on the DIS-TE test set. The code is available at: https://github.com/Picsart-AI-Research/FlowDIS

cs.CV↗

arXiv2025

BEN: Using Confidence-Guided Matting for Dichotomous Image Segmentation

Current approaches to dichotomous image segmentation (DIS) treat image matting and object segmentation as fundamentally different tasks. As improvements in image segmentation become increasingly challenging to achieve, combining image matting and grayscale segmentation techniques offers promising new directions for architectural innovation. Inspired by the possibility of aligning these two model tasks, we propose a new architectural approach for DIS called Confidence-Guided Matting (CGM). We created the first CGM model called Background Erase Network (BEN). BEN consists of two components: BEN Base for initial segmentation and BEN Refiner for confidence-based refinement. Our approach achieves substantial improvements over current state-of-the-art methods on the DIS5K validation dataset, demonstrating that matting-based refinement can significantly enhance segmentation quality. This work introduces a new paradigm for integrating matting and segmentation techniques, improving fine-grained object boundary prediction in computer vision.

cs.CV↗

arXiv2024

SAM-OCTA: Prompting Segment-Anything for OCTA Image Segmentation

Segmenting specific targets or biomarkers is necessary to analyze optical coherence tomography angiography (OCTA) images. Previous methods typically segment all the targets in an OCTA sample, such as retinal vessels (RVs). Although these methods perform well in accuracy and precision, OCTA analyses often focusing local information within the images which has not been fulfilled. In this paper, we propose a method called SAM-OCTA for local segmentation in OCTA images. The method fine-tunes a pre-trained segment anything model (SAM) using low-rank adaptation (LoRA) and utilizes prompt points for local RVs, arteries, and veins segmentation in OCTA. To explore the effect and mechanism of prompt points, we set up global and local segmentation modes with two prompt point generation strategies, namely random selection and special annotation. Considering practical usage, we conducted extended experiments with different model scales and analyzed the model performance before and after fine-tuning besides the general segmentation task. From comprehensive experimental results with the OCTA-500 dataset, our SAM-OCTA method has achieved state-of-the-art performance in common OCTA segmentation tasks related to RV and FAZ, and it also performs accurate segmentation of artery-vein and local vessels. The code is available at https://github.com/ShellRedia/SAM-OCTA-extend.

cs.LG↗

arXiv2024

HyperSpace: Hypernetworks for spacing-adaptive image segmentation

Medical images are often acquired in different settings, requiring harmonization to adapt to the operating point of algorithms. Specifically, to standardize the physical spacing of imaging voxels in heterogeneous inference settings, images are typically resampled before being processed by deep learning models. However, down-sampling results in loss of information, whereas upsampling introduces redundant information leading to inefficient resource utilization. To overcome these issues, we propose to condition segmentation models on the voxel spacing using hypernetworks. Our approach allows processing images at their native resolutions or at resolutions adjusted to the hardware and time constraints at inference time. Our experiments across multiple datasets demonstrate that our approach achieves competitive performance compared to resolution-specific models, while offering greater flexibility for the end user. This also simplifies model development, deployment and maintenance. Our code is available at https://github.com/ImFusionGmbH/HyperSpace.

eess.IV↗

arXiv2021

BUSIS: A Benchmark for Breast Ultrasound Image Segmentation

Breast ultrasound (BUS) image segmentation is challenging and critical for BUS Comput-er-Aided Diagnosis (CAD) systems. Many BUS segmentation approaches have been studied in the last two decades, but the performances of most approaches have been assessed using relatively small private datasets with different quantitative metrics, which results in a discrepancy in performance comparison. Therefore, there is a pressing need for building a benchmark to compare existing methods using a public dataset objectively, to determine the performance of the best breast tumor segmentation algorithm available today, and to investigate what segmentation strategies are valuable in clinical practice and theoretical study. In this work, a benchmark for B-mode breast ultrasound image segmentation is presented. In the benchmark, 1) we collected 562 breast ultrasound images, prepared a software tool, and involved four radiologists in obtaining accurate annotations through standardized procedures; 2) we extensively compared the performance of sixteen state-of-the-art segmentation methods and discussed their advantages and disadvantages; 3) we proposed a set of valuable quantitative metrics to evaluate both semi-automatic and fully automatic segmentation approaches; and 4) the successful segmentation strategies and possible future improvements are discussed in details.

cs.CV↗

arXiv2022

Cartoon-texture evolution for two-region image segmentation

Two-region image segmentation is the process of dividing an image into two regions of interest, i.e., the foreground and the background. To this aim, Chan et al. [Chan, Esedoglu, Nikolova, SIAM Journal on Applied Mathematics 66(5), 1632-1648, 2006] designed a model well suited for smooth images. One drawback of this model is that it may produce a bad segmentation when the image contains oscillatory components. Based on a cartoon-texture decomposition of the image to be segmented, we propose a new model that is able to produce an accurate segmentation of images also containing noise or oscillatory information like texture. The novel model leads to a non-smooth constrained optimization problem which we solve by means of the ADMM method. The convergence of the numerical scheme is also proved. Several experiments on smooth, noisy, and textural images show the effectiveness of the proposed model.

math.NA↗

arXiv2023

Zero-Shot Digital Rock Image Segmentation with a Fine-Tuned Segment Anything Model

Accurate image segmentation is crucial in reservoir modelling and material characterization, enhancing oil and gas extraction efficiency through detailed reservoir models. This precision offers insights into rock properties, advancing digital rock physics understanding. However, creating pixel-level annotations for complex CT and SEM rock images is challenging due to their size and low contrast, lengthening analysis time. This has spurred interest in advanced semi-supervised and unsupervised segmentation techniques in digital rock image analysis, promising more efficient, accurate, and less labour-intensive methods. Meta AI's Segment Anything Model (SAM) revolutionized image segmentation in 2023, offering interactive and automated segmentation with zero-shot capabilities, essential for digital rock physics with limited training data and complex image features. Despite its advanced features, SAM struggles with rock CT/SEM images due to their absence in its training set and the low-contrast nature of grayscale images. Our research fine-tunes SAM for rock CT/SEM image segmentation, optimizing parameters and handling large-scale images to improve accuracy. Experiments on rock CT and SEM images show that fine-tuning significantly enhances SAM's performance, enabling high-quality mask generation in digital rock image analysis. Our results demonstrate the feasibility and effectiveness of the fine-tuned SAM model (RockSAM) for rock images, offering segmentation without extensive training or complex labelling.

cs.CV↗

arXiv2025

Omni-Fusion of Spatial and Spectral for Hyperspectral Image Segmentation

Medical Hyperspectral Imaging (MHSI) has emerged as a promising tool for enhanced disease diagnosis, particularly in computational pathology, offering rich spectral information that aids in identifying subtle biochemical properties of tissues. Despite these advantages, effectively fusing both spatial-dimensional and spectral-dimensional information from MHSIs remains challenging due to its high dimensionality and spectral redundancy inherent characteristics. To solve the above challenges, we propose a novel spatial-spectral omni-fusion network for hyperspectral image segmentation, named as Omni-Fuse. Here, we introduce abundant cross-dimensional feature fusion operations, including a cross-dimensional enhancement module that refines both spatial and spectral features through bidirectional attention mechanisms, a spectral-guided spatial query selection to select the most spectral-related spatial feature as the query, and a two-stage cross-dimensional decoder which dynamically guide the model to focus on the selected spatial query. Despite of numerous attention blocks, Omni-Fuse remains efficient in execution. Experiments on two microscopic hyperspectral image datasets show that our approach can significantly improve the segmentation performance compared with the state-of-the-art methods, with over 5.73 percent improvement in DSC. Code available at: https://github.com/DeepMed-Lab-ECNU/Omni-Fuse.

cs.CV↗

arXiv2025

TK-Mamba: Marrying KAN With Mamba for Text-Driven 3D Medical Image Segmentation

3D medical image segmentation is important for clinical diagnosis and treatment but faces challenges from high-dimensional data and complex spatial dependencies. Traditional single-modality networks, such as CNNs and Transformers, are often limited by computational inefficiency and constrained contextual modeling in 3D settings. To alleviate these limitations, we propose TK-Mamba, a multimodal framework that fuses the linear-time Mamba with Kolmogorov-Arnold Networks (KAN) to form an efficient hybrid backbone. Our approach is characterized by two primary technical contributions. Firstly, we introduce the novel 3D-Group-Rational KAN (3D-GR-KAN), which marks the first application of KAN in 3D medical imaging, providing a superior and computationally efficient nonlinear feature transformation crucial for complex volumetric structures. Secondly, we devise a dual-branch text-driven strategy using Pubmedclip's embeddings. This strategy significantly enhances segmentation robustness and accuracy by simultaneously capturing inter-organ semantic relationships to mitigate label inconsistencies and aligning image features with anatomical texts. By combining this advanced backbone and vision-language knowledge, TK-Mamba offers a unified and scalable solution for both multi-organ and tumor segmentation. Experiments on multiple datasets demonstrate that our framework achieves state-of-the-art performance in both organ and tumor segmentation tasks, surpassing existing methods in both accuracy and efficiency. Our code is publicly available at https://github.com/yhy-whu/TK-Mamba

cs.CV↗

arXiv2026

MS-DKC: A Dataset Knowledge Card Framework for Designing and Adapting Medical Image Segmentation Models

Medical image segmentation is often framed as a search for stronger architectures, but this can obscure a more fundamental question: what does the dataset require from the model? In medical imaging, this requirement is shaped by foreground occupancy, morphology, boundary ambiguity, topology sensitivity, annotation quality, acquisition variation, and operating point. This paper introduces the Medical Segmentation Dataset Knowledge Card (MS-DKC), a framework for making these factors explicit. MS-DKC records dataset evidence through image/acquisition, morphology, supervision, context-dependence, and deployment-risk descriptors. These descriptors are mapped to failure modes, design priors, and risk-aligned criteria, making segmentation design more traceable than architecture-first comparison. We evaluate MS-DKC on DRIVE, ISIC2018, and ACDC, representing distinct regimes. DRIVE contains sparse, thin, branching vessels, favoring detail-preserving models, sensitivity-aware optimization, threshold analysis, and topology-aware metrics. DKC-TNet-v2 achieved Dice 0.8044 and IoU 0.6730 with 35103 parameters, while SA-UNetv2-DKC-AmbRef reached Dice 0.8141, IoU 0.6865, sensitivity 0.8265, specificity 0.9804, and AUC 0.9853. ISIC2018 involves compact but appearance-variable lesions; validation-constrained score-function selection on Att-Next-Topo/ATTNext produced MS-DKC-AttNextTopo-VCSF-NoAug with Dice 0.8872, IoU 0.8214, precision 0.9173, Boundary F1 0.4878, and ASSD 4.13, while plausible additions failed to improve the risk-aligned profile. ACDC provides a multi-class cardiac case, where MS-DKC recommends four-class softmax segmentation, class-balanced Dice/CE supervision, and class-wise surface evaluation. Overall, the results support dataset-conditioned design: different datasets require different priors, operating points, and evidence before a model can be judged appropriate.

cs.CV↗

arXiv2026

Quality-Guided Semi-Supervised Learning for Medical Image Segmentation

Training accurate medical image segmentation models requires large amounts of densely annotated data, which is costly and time-consuming to obtain. Semi-supervised learning (SSL) alleviates this by learning from both abundant unlabeled data and limited labeled data. However, most modern SSL methods rely on pseudolabels for unlabeled data, and typically assess their reliability through model confidence or uncertainty, measures that are self-referential and lack explicit grounding in segmentation quality. Instead, we propose a quality-guided SSL framework that trains a dedicated network to estimate segmentation quality from image-mask pairs. The predictor is trained on variable-quality masks generated through synthetic corruptions augmented with imperfect outputs from partially trained segmentation models, capturing realistic error patterns encountered during training. We integrate the quality predictor into SSL through two complementary mechanisms: a quality-aware regularization loss and a quality-based pseudolabel sample reweighting scheme. We show that our method serves as a drop-in enhancement to existing SSL frameworks. Extensive experiments across five datasets and multiple architectures demonstrate consistent improvements over competing SSL methods, advancing the state-of-the-art in semi-supervised medical image segmentation.

cs.CV↗

arXiv2024

Rotated Multi-Scale Interaction Network for Referring Remote Sensing Image Segmentation

Referring Remote Sensing Image Segmentation (RRSIS) is a new challenge that combines computer vision and natural language processing, delineating specific regions in aerial images as described by textual queries. Traditional Referring Image Segmentation (RIS) approaches have been impeded by the complex spatial scales and orientations found in aerial imagery, leading to suboptimal segmentation results. To address these challenges, we introduce the Rotated Multi-Scale Interaction Network (RMSIN), an innovative approach designed for the unique demands of RRSIS. RMSIN incorporates an Intra-scale Interaction Module (IIM) to effectively address the fine-grained detail required at multiple scales and a Cross-scale Interaction Module (CIM) for integrating these details coherently across the network. Furthermore, RMSIN employs an Adaptive Rotated Convolution (ARC) to account for the diverse orientations of objects, a novel contribution that significantly enhances segmentation accuracy. To assess the efficacy of RMSIN, we have curated an expansive dataset comprising 17,402 image-caption-mask triplets, which is unparalleled in terms of scale and variety. This dataset not only presents the model with a wide range of spatial and rotational scenarios but also establishes a stringent benchmark for the RRSIS task, ensuring a rigorous evaluation of performance. Our experimental evaluations demonstrate the exceptional performance of RMSIN, surpassing existing state-of-the-art models by a significant margin. All datasets and code are made available at https://github.com/Lsan2401/RMSIN.

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