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arXiv2025

CP2M: Clustered-Patch-Mixed Mosaic Augmentation for Aerial Image Segmentation

Remote sensing image segmentation is pivotal for earth observation, underpinning applications such as environmental monitoring and urban planning. Due to the limited annotation data available in remote sensing images, numerous studies have focused on data augmentation as a means to alleviate overfitting in deep learning networks. However, some existing data augmentation strategies rely on simple transformations that may not sufficiently enhance data diversity or model generalization capabilities. This paper proposes a novel augmentation strategy, Clustered-Patch-Mixed Mosaic (CP2M), designed to address these limitations. CP2M integrates a Mosaic augmentation phase with a clustered patch mix phase. The former stage constructs a new sample from four random samples, while the latter phase uses the connected component labeling algorithm to ensure the augmented data maintains spatial coherence and avoids introducing irrelevant semantics when pasting random patches. Our experiments on the ISPRS Potsdam dataset demonstrate that CP2M substantially mitigates overfitting, setting new benchmarks for segmentation accuracy and model robustness in remote sensing tasks.

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arXiv2024

FPL+: Filtered Pseudo Label-based Unsupervised Cross-Modality Adaptation for 3D Medical Image Segmentation

Adapting a medical image segmentation model to a new domain is important for improving its cross-domain transferability, and due to the expensive annotation process, Unsupervised Domain Adaptation (UDA) is appealing where only unlabeled images are needed for the adaptation. Existing UDA methods are mainly based on image or feature alignment with adversarial training for regularization, and they are limited by insufficient supervision in the target domain. In this paper, we propose an enhanced Filtered Pseudo Label (FPL+)-based UDA method for 3D medical image segmentation. It first uses cross-domain data augmentation to translate labeled images in the source domain to a dual-domain training set consisting of a pseudo source-domain set and a pseudo target-domain set. To leverage the dual-domain augmented images to train a pseudo label generator, domain-specific batch normalization layers are used to deal with the domain shift while learning the domain-invariant structure features, generating high-quality pseudo labels for target-domain images. We then combine labeled source-domain images and target-domain images with pseudo labels to train a final segmentor, where image-level weighting based on uncertainty estimation and pixel-level weighting based on dual-domain consensus are proposed to mitigate the adverse effect of noisy pseudo labels. Experiments on three public multi-modal datasets for Vestibular Schwannoma, brain tumor and whole heart segmentation show that our method surpassed ten state-of-the-art UDA methods, and it even achieved better results than fully supervised learning in the target domain in some cases.

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arXiv2025

Retrieval-augmented Few-shot Medical Image Segmentation with Foundation Models

Medical image segmentation is crucial for clinical decision-making, but the scarcity of annotated data presents significant challenges. Few-shot segmentation (FSS) methods show promise but often require training on the target domain and struggle to generalize across different modalities. Similarly, adapting foundation models like the Segment Anything Model (SAM) for medical imaging has limitations, including the need for finetuning and domain-specific adaptation. To address these issues, we propose a novel method that adapts DINOv2 and Segment Anything Model 2 (SAM 2) for retrieval-augmented few-shot medical image segmentation. Our approach uses DINOv2's feature as query to retrieve similar samples from limited annotated data, which are then encoded as memories and stored in memory bank. With the memory attention mechanism of SAM 2, the model leverages these memories as conditions to generate accurate segmentation of the target image. We evaluated our framework on three medical image segmentation tasks, demonstrating superior performance and generalizability across various modalities without the need for any retraining or finetuning. Overall, this method offers a practical and effective solution for few-shot medical image segmentation and holds significant potential as a valuable annotation tool in clinical applications.

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arXiv2018

IEOPF: An Active Contour Model for Image Segmentation with Inhomogeneities Estimated by Orthogonal Primary Functions

Image segmentation is still an open problem especially when intensities of the interested objects are overlapped due to the presence of intensity inhomogeneity (also known as bias field). To segment images with intensity inhomogeneities, a bias correction embedded level set model is proposed where Inhomogeneities are Estimated by Orthogonal Primary Functions (IEOPF). In the proposed model, the smoothly varying bias is estimated by a linear combination of a given set of orthogonal primary functions. An inhomogeneous intensity clustering energy is then defined and membership functions of the clusters described by the level set function are introduced to rewrite the energy as a data term of the proposed model. Similar to popular level set methods, a regularization term and an arc length term are also included to regularize and smooth the level set function, respectively. The proposed model is then extended to multichannel and multiphase patterns to segment colourful images and images with multiple objects, respectively. It has been extensively tested on both synthetic and real images that are widely used in the literature and public BrainWeb and IBSR datasets. Experimental results and comparison with state-of-the-art methods demonstrate that advantages of the proposed model in terms of bias correction and segmentation accuracy.

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arXiv2024

SAM-Med3D-MoE: Towards a Non-Forgetting Segment Anything Model via Mixture of Experts for 3D Medical Image Segmentation

Volumetric medical image segmentation is pivotal in enhancing disease diagnosis, treatment planning, and advancing medical research. While existing volumetric foundation models for medical image segmentation, such as SAM-Med3D and SegVol, have shown remarkable performance on general organs and tumors, their ability to segment certain categories in clinical downstream tasks remains limited. Supervised Finetuning (SFT) serves as an effective way to adapt such foundation models for task-specific downstream tasks but at the cost of degrading the general knowledge previously stored in the original foundation model.To address this, we propose SAM-Med3D-MoE, a novel framework that seamlessly integrates task-specific finetuned models with the foundational model, creating a unified model at minimal additional training expense for an extra gating network. This gating network, in conjunction with a selection strategy, allows the unified model to achieve comparable performance of the original models in their respective tasks both general and specialized without updating any parameters of them.Our comprehensive experiments demonstrate the efficacy of SAM-Med3D-MoE, with an average Dice performance increase from 53 to 56.4 on 15 specific classes. It especially gets remarkable gains of 29.6, 8.5, 11.2 on the spinal cord, esophagus, and right hip, respectively. Additionally, it achieves 48.9 Dice on the challenging SPPIN2023 Challenge, significantly surpassing the general expert's performance of 32.3. We anticipate that SAM-Med3D-MoE can serve as a new framework for adapting the foundation model to specific areas in medical image analysis. Codes and datasets will be publicly available.

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arXiv2022

ReSTR: Convolution-free Referring Image Segmentation Using Transformers

Referring image segmentation is an advanced semantic segmentation task where target is not a predefined class but is described in natural language. Most of existing methods for this task rely heavily on convolutional neural networks, which however have trouble capturing long-range dependencies between entities in the language expression and are not flexible enough for modeling interactions between the two different modalities. To address these issues, we present the first convolution-free model for referring image segmentation using transformers, dubbed ReSTR. Since it extracts features of both modalities through transformer encoders, it can capture long-range dependencies between entities within each modality. Also, ReSTR fuses features of the two modalities by a self-attention encoder, which enables flexible and adaptive interactions between the two modalities in the fusion process. The fused features are fed to a segmentation module, which works adaptively according to the image and language expression in hand. ReSTR is evaluated and compared with previous work on all public benchmarks, where it outperforms all existing models.

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arXiv2026

MCSeg: Pre-training and Fine-tuning Volumetric Pyramid Transformer for Multi-modal Cardiac Image Segmentation

Automatic cardiac image segmentation is pivotal for diagnosing and treating cardiac diseases. In this work, we introduce MCSeg, a volumetric transformer-based network tailored for multi-modal cardiac segmentation. To overcome the architectural mismatch inherent in existing hybrid networks, we propose a novel Scaling Feature Pyramid (SFP). Unlike conventional skip connections, the SFP effectively bridges the single-scale 3D Vision Transformer (ViT) encoder and the multi-scale CNN decoder by transforming the ViT's output into a hierarchical feature pyramid, ensuring that global contextual information is effectively leveraged. For the training paradigm, the ViT encoder first undergoes self-supervised pre-training via masked image modeling. Subsequently, the network is fine-tuned on downstream tasks, during which a regional mutual information (RMI) loss is integrated to improve boundary segmentation accuracy. In experiments, MCSeg consistently outperforms eleven SOTA methods on CT dataset ImageCHD, multi-modal dataset MM-WHS, MRI dataset HVSMR-2.0 and MSD Heart, highlighting the effectiveness of our MCSeg for multi-modal cardiac segmentation tasks. Furthermore, MCSeg's superior performance in few-shot experiment showcases its significant potential in adapting to limited data scenarios. Codes and pre-trained ViT-B weights are open-sourced at https://openi.pcl.ac.cn/OpenMedIA/MCSeg

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arXiv2025

TABNet: A Triplet Augmentation Self-Recovery Framework with Boundary-Aware Pseudo-Labels for Medical Image Segmentation

Background and objective: Medical image segmentation is a core task in various clinical applications. However, acquiring large-scale, fully annotated medical image datasets is both time-consuming and costly. Scribble annotations, as a form of sparse labeling, provide an efficient and cost-effective alternative for medical image segmentation. However, the sparsity of scribble annotations limits the feature learning of the target region and lacks sufficient boundary supervision, which poses significant challenges for training segmentation networks. Methods: We propose TAB Net, a novel weakly-supervised medical image segmentation framework, consisting of two key components: the triplet augmentation self-recovery (TAS) module and the boundary-aware pseudo-label supervision (BAP) module. The TAS module enhances feature learning through three complementary augmentation strategies: intensity transformation improves the model's sensitivity to texture and contrast variations, cutout forces the network to capture local anatomical structures by masking key regions, and jigsaw augmentation strengthens the modeling of global anatomical layout by disrupting spatial continuity. By guiding the network to recover complete masks from diverse augmented inputs, TAS promotes a deeper semantic understanding of medical images under sparse supervision. The BAP module enhances pseudo-supervision accuracy and boundary modeling by fusing dual-branch predictions into a loss-weighted pseudo-label and introducing a boundary-aware loss for fine-grained contour refinement. Results: Experimental evaluations on two public datasets, ACDC and MSCMR seg, demonstrate that TAB Net significantly outperforms state-of-the-art methods for scribble-based weakly supervised segmentation. Moreover, it achieves performance comparable to that of fully supervised methods.

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arXiv2024

Parallel Watershed Partitioning: GPU-Based Hierarchical Image Segmentation

Many image processing applications rely on partitioning an image into disjoint regions whose pixels are 'similar.' The watershed and waterfall transforms are established mathematical morphology pixel clustering techniques. They are both relevant to modern applications where groups of pixels are to be decided upon in one go, or where adjacency information is relevant. We introduce three new parallel partitioning algorithms for GPUs. By repeatedly applying watershed algorithms, we produce waterfall results which form a hierarchy of partition regions over an input image. Our watershed algorithms attain competitive execution times in both 2D and 3D, processing an 800 megavoxel image in less than 1.4 sec. We also show how to use this fully deterministic image partitioning as a pre-processing step to machine learning based semantic segmentation. This replaces the role of superpixel algorithms, and results in comparable accuracy and faster training times.

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arXiv2012

An Unsupervised Dynamic Image Segmentation using Fuzzy Hopfield Neural Network based Genetic Algorithm

This paper proposes a Genetic Algorithm based segmentation method that can automatically segment gray-scale images. The proposed method mainly consists of spatial unsupervised grayscale image segmentation that divides an image into regions. The aim of this algorithm is to produce precise segmentation of images using intensity information along with neighborhood relationships. In this paper, Fuzzy Hopfield Neural Network (FHNN) clustering helps in generating the population of Genetic algorithm which there by automatically segments the image. This technique is a powerful method for image segmentation and works for both single and multiple-feature data with spatial information. Validity index has been utilized for introducing a robust technique for finding the optimum number of components in an image. Experimental results shown that the algorithm generates good quality segmented image.

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arXiv2024

Systematic review of image segmentation using complex networks

This review presents various image segmentation methods using complex networks. Image segmentation is one of the important steps in image analysis as it helps analyze and understand complex images. At first, it has been tried to classify complex networks based on how it being used in image segmentation. In computer vision and image processing applications, image segmentation is essential for analyzing complex images with irregular shapes, textures, or overlapping boundaries. Advanced algorithms make use of machine learning, clustering, edge detection, and region-growing techniques. Graph theory principles combined with community detection-based methods allow for more precise analysis and interpretation of complex images. Hybrid approaches combine multiple techniques for comprehensive, robust segmentation, improving results in computer vision and image processing tasks.

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arXiv2024

Review of Fruit Tree Image Segmentation

Fruit tree image segmentation is an essential problem in automating a variety of agricultural tasks such as phenotyping, harvesting, spraying, and pruning. Many research papers have proposed a diverse spectrum of solutions suitable to specific tasks and environments. The review scope of this paper is confined to the front views of fruit trees and based on 158 relevant papers collected using a newly designed crawling review method. These papers are systematically reviewed based on a taxonomy that sequentially considers the method, image, task, and fruit. This taxonomy will assist readers to intuitively grasp the big picture of these research activities. Our review reveals that the most noticeable deficiency of the previous studies was the lack of a versatile dataset and segmentation model that could be applied to a variety of tasks and environments. Six important future research tasks are suggested, with the expectation that these will pave the way to building a versatile tree segmentation module.

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arXiv2021

A Random Point Initialization Approach to Image Segmentation with Variational Level-sets

Image segmentation is an essential component in many image processing and computer vision tasks. The primary goal of image segmentation is to simplify an image for easier analysis, and there are two broad approaches for achieving this: edge based methods, which extract the boundaries of specific known objects, and region based methods, which partition the image into regions that are statistically homogeneous. One of the more prominent edge finding methods, known as the level set method, evolves a zero-level contour in the image plane with gradient descent until the contour has converged to the object boundaries. While the classical level set method and its variants have proved successful in segmenting real images, they are susceptible to becoming stuck in noisy regions of the image plane without a priori knowledge of the image and they are unable to provide details beyond object outer boundary locations. We propose a modification to the variational level set image segmentation method that can quickly detect object boundaries by making use of random point initialization. We demonstrate the efficacy of our approach by comparing the performance of our method on real images to that of the prominent Canny Method.

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arXiv2022

Enhancing Pseudo Label Quality for Semi-Supervised Domain-Generalized Medical Image Segmentation

Generalizing the medical image segmentation algorithms to unseen domains is an important research topic for computer-aided diagnosis and surgery. Most existing methods require a fully labeled dataset in each source domain. Although some researchers developed a semi-supervised domain generalized method, it still requires the domain labels. This paper presents a novel confidence-aware cross pseudo supervision algorithm for semi-supervised domain generalized medical image segmentation. The main goal is to enhance the pseudo label quality for unlabeled images from unknown distributions. To achieve it, we perform the Fourier transformation to learn low-level statistic information across domains and augment the images to incorporate cross-domain information. With these augmentations as perturbations, we feed the input to a confidence-aware cross pseudo supervision network to measure the variance of pseudo labels and regularize the network to learn with more confident pseudo labels. Our method sets new records on public datasets, i.e., M&Ms and SCGM. Notably, without using domain labels, our method surpasses the prior art that even uses domain labels by 11.67% on Dice on M&Ms dataset with 2% labeled data. Code is available at https://github.com/XMed-Lab/EPL_SemiDG.

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arXiv2025

Coordinative Learning with Ordinal and Relational Priors for Volumetric Medical Image Segmentation

Volumetric medical image segmentation presents unique challenges due to the inherent anatomical structure and limited availability of annotations. While recent methods have shown promise by contrasting spatial relationships between slices, they rely on hard binary thresholds to define positive and negative samples, thereby discarding valuable continuous information about anatomical similarity. Moreover, these methods overlook the global directional consistency of anatomical progression, resulting in distorted feature spaces that fail to capture the canonical anatomical manifold shared across patients. To address these limitations, we propose Coordinative Ordinal-Relational Anatomical Learning (CORAL) to capture both local and global structure in volumetric images. First, CORAL employs a contrastive ranking objective to leverage continuous anatomical similarity, ensuring relational feature distances between slices are proportional to their anatomical position differences. In addition, CORAL incorporates an ordinal objective to enforce global directional consistency, aligning the learned feature distribution with the canonical anatomical progression across patients. Learning these inter-slice relationships produces anatomically informed representations that benefit the downstream segmentation task. Through this coordinative learning framework, CORAL achieves state-of-the-art performance on benchmark datasets under limited-annotation settings while learning representations with meaningful anatomical structure. Code is available at https://github.com/haoyiwang25/CORAL.

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arXiv2025

Re-purposing SAM into Efficient Visual Projectors for MLLM-Based Referring Image Segmentation

Recently, Referring Image Segmentation (RIS) frameworks that pair the Multimodal Large Language Model (MLLM) with the Segment Anything Model (SAM) have achieved impressive results. However, adapting MLLM to segmentation is computationally intensive, primarily due to visual token redundancy. We observe that traditional patch-wise visual projectors struggle to strike a balance between reducing the number of visual tokens and preserving semantic clarity, often retaining overly long token sequences to avoid performance drops. Inspired by text tokenizers, we propose a novel semantic visual projector that leverages semantic superpixels generated by SAM to identify "visual words" in an image. By compressing and projecting semantic superpixels as visual tokens, our approach adaptively shortens the token sequence according to scene complexity while minimizing semantic loss in compression. To mitigate loss of information, we propose a semantic superpixel positional embedding to strengthen MLLM's awareness of superpixel geometry and position, alongside a semantic superpixel aggregator to preserve both fine-grained details inside superpixels and global context outside. Experiments show that our method cuts visual tokens by 93% without compromising performance, notably speeding up MLLM training and inference, and outperforming existing compressive visual projectors on RIS.

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arXiv2025

TreeFedDG: Alleviating Global Drift in Federated Domain Generalization for Medical Image Segmentation

In medical image segmentation tasks, Domain Generalization (DG) under the Federated Learning (FL) framework is crucial for addressing challenges related to privacy protection and data heterogeneity. However, traditional federated learning methods fail to account for the imbalance in information aggregation across clients in cross-domain scenarios, leading to the Global Drift (GD) problem and a consequent decline in model generalization performance. This motivates us to delve deeper and define a new critical issue: global drift in federated domain generalization for medical imaging (FedDG-GD). In this paper, we propose a novel tree topology framework called TreeFedDG. First, starting from the distributed characteristics of medical images, we design a hierarchical parameter aggregation method based on a tree-structured topology to suppress deviations in the global model direction. Second, we introduce a parameter difference-based style mixing method (FedStyle), which enforces mixing among clients with maximum parameter differences to enhance robustness against drift. Third, we develop a a progressive personalized fusion strategy during model distribution, ensuring a balance between knowledge transfer and personalized features. Finally, during the inference phase, we use feature similarity to guide the retrieval of the most relevant model chain from the tree structure for ensemble decision-making, thereby fully leveraging the advantages of hierarchical knowledge. We conducted extensive experiments on two publicly available datasets. The results demonstrate that our method outperforms other state-of-the-art domain generalization approaches in these challenging tasks and achieves better balance in cross-domain performance.

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arXiv2025

Dynamic Dictionary Learning for Remote Sensing Image Segmentation

Remote sensing image segmentation faces persistent challenges in distinguishing morphologically similar categories and adapting to diverse scene variations. While existing methods rely on implicit representation learning paradigms, they often fail to dynamically adjust semantic embeddings according to contextual cues, leading to suboptimal performance in fine-grained scenarios such as cloud thickness differentiation. This work introduces a dynamic dictionary learning framework that explicitly models class ID embeddings through iterative refinement. The core contribution lies in a novel dictionary construction mechanism, where class-aware semantic embeddings are progressively updated via multi-stage alternating cross-attention querying between image features and dictionary embeddings. This process enables adaptive representation learning tailored to input-specific characteristics, effectively resolving ambiguities in intra-class heterogeneity and inter-class homogeneity. To further enhance discriminability, a contrastive constraint is applied to the dictionary space, ensuring compact intra-class distributions while maximizing inter-class separability. Extensive experiments across both coarse- and fine-grained datasets demonstrate consistent improvements over state-of-the-art methods, particularly in two online test benchmarks (LoveDA and UAVid). Code is available at https://anonymous.4open.science/r/D2LS-8267/.

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